{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:00:50Z","timestamp":1790870450203,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":3170,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic haplotypes at five marker loci that are closely linked to the DYT1 gene on chromosome 9q were determined in 10 Ashkenazi Jewish patients with focal hand dystonia (eight with musician's cramp, two with writer's cramp). The founder haplotype associated with &gt;90% of cases of generalized dystonia in the Ashkenazi Jewish population could not be constructed from any of the twenty chromosomes. Potential haplotypes were determined, and no common haplotype was discerned in these patients. These findings argue against a role for the founder mutation in the DYT1 gene in the etiology of occupational hand dystonia in this ethnic group. Further, if the DYT1 gene is involved in these later onset dystonias, there is no evidence for a common mutation in the Ashkenazic Jewish population. It appears that excessive, repetitive use, possibly in combination with ulnar neuropathy, may serve as the inciting cause of some focal dystonias.<\/jats:p>","DOI":"10.1002\/mds.870110208","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T09:45:58Z","timestamp":1104486358000},"page":"163-166","source":"Crossref","is-referenced-by-count":19,"title":["Haplotype analysis at the DYT1 Locus in ashkenazi jewish patients with occupational hand dystonia"],"prefix":"10.1002","volume":"11","author":[{"given":"T.","family":"Gasser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Ozelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hallett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Charness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"Hochberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. O.","family":"Breakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"332","volume-title":"Movement disorders 2","author":"Fahn S","year":"1987"},{"key":"e_1_2_1_3_2","first-page":"533","article-title":"Segregation analysis of idiopathic torsion dystonia in Ashkenazi Jews suggests autosomal domainant inheritance","volume":"46","author":"Risch NJ","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90188-8"},{"key":"e_1_2_1_6_2","first-page":"468","article-title":"The DYT1 gene on 9q34 is responsible for most cases of early\u2010onset idiopathic torsion dystonia (ITD) in non\u2010Jews","volume":"55","author":"Kramer P","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.2.283"},{"key":"e_1_2_1_9_2","first-page":"619","article-title":"Strong allelic association between the torsion dystonia gene (DYT1) and loci on chromosome 9q34 in Ashkenazi Jews","volume":"50","author":"Ozelius LJ","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360514"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0295-152"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/01677068609106846"},{"key":"e_1_2_1_13_2","first-page":"388","article-title":"Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction","volume":"44","author":"Weber JL","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1376"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90370-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1992.tb00707.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290315"},{"key":"e_1_2_1_18_2","first-page":"457","article-title":"Writer's cramp","volume":"50","author":"Sheehy MP","year":"1988","journal-title":"Adv Neurol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.767"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.3.398"},{"key":"e_1_2_1_21_2","first-page":"83","article-title":"Autosomal dominant torsion dystonia in a Swedish family","volume":"50","author":"Forsgren L","year":"1988","journal-title":"Adv Neurol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080413"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260505"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.04210040053005"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880180607"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870110208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870110208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:51:04Z","timestamp":1760957464000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870110208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1002\/mds.870110208"],"URL":"https:\/\/doi.org\/10.1002\/mds.870110208","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}