{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:28:07Z","timestamp":1761596887186,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2986,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L\u2010Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L\u2010Dopa was abolished by administration of a D<jats:sup>2<\/jats:sup> antagonist and was fully reproduced by a D<jats:sup>2<\/jats:sup> agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.<\/jats:p>","DOI":"10.1002\/mds.870110513","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T09:47:09Z","timestamp":1104486429000},"page":"567-570","source":"Crossref","is-referenced-by-count":11,"title":["Postencephalitic stereotyped involuntary movements responsive to <scp>L<\/scp>\u2010Dopa"],"prefix":"10.1002","volume":"11","author":[{"given":"F.","family":"Picard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"de Saint\u2010Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marescaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90820-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.1.281"},{"key":"e_1_2_1_4_2","unstructured":"L\u00e9vyG.Contribution \u00e0 l'\u00e9tude des manifestations tardives de l'enc\u00e9phalite \u00e9pid\u00e9mique (formes prolong\u00e9es et reprises tardives) [Th\u00e8se M\u00e9decine]. Universit\u00e9 de Paris 1922."},{"volume-title":"Its sequelae and treatment","year":"1931","author":"Von Economo C","key":"e_1_2_1_5_2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/4575888"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4723.77"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4874.1298"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4976.1141"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5748.532"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.8.670"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.1.19"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530120034007"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1563"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300106"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.2_Part_1.174"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340518"},{"key":"e_1_2_1_18_2","first-page":"213","article-title":"Juvenile onset Parkinson's disease","volume":"45","author":"Gershanik OS","year":"1986","journal-title":"Adv Neurol"},{"key":"e_1_2_1_19_2","first-page":"513","article-title":"Le syndrome excito\u2010moteur de l'enc\u00e9phalite \u00e9pid\u00e9mique","volume":"36","author":"Marie P","year":"1920","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)91751-6"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.4.487"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1965.00460270003001"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4772.1317"},{"key":"e_1_2_1_24_2","first-page":"753","article-title":"Ent\u00e9rovirus (poliomy\u00e9lite, coxsackie, \u00e9cho) et maladies du syst\u00e8me nerveux. 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