{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:28:06Z","timestamp":1765484886978,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2864,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The natural course of calcium\u2010entry blocker\u2013induced parkinsonism was evaluated in 13 elderly patients previously exposed to cinnarizine or flunarizine or both for a median period of 7 months. Clinical assessments were carried out before drug discontinuation and twice thereafter over a period lasting \u22647 years. None of the patients showed a full recovery of extrapyramidal signs, indicating that the long\u2010term prognosis of the parkinsonism is less benign than previously reported. Two main patterns of clinical outcome were recognized (i.e., \u201cremittent\u201d and \u201cpersistent and not progressive\u201dparkinsonism), whereas the development of a progressive disorder was observed only in one patient. No significant correlation was found between the patterns of outcome and some clinical variables, such as total duration of exposure to cinnarizine and flunarizine, cumulative drug dosages, and age at onset of parkinsonism. There was no significant difference in terms of family history of essential tremor or parkinsonism or both among the patients with the two main patterns of clinical course.<\/jats:p>","DOI":"10.1002\/mds.870120119","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:16:17Z","timestamp":1117311377000},"page":"107-110","source":"Crossref","is-referenced-by-count":61,"title":["A long\u2010term follow\u2010up study of cinnarizine\u2010 and flunarizine\u2010induced parkinsonism"],"prefix":"10.1002","volume":"12","author":[{"given":"A.","family":"Negrotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Calzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040205"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.2.288"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199202000-00003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530160025009"},{"volume-title":"Tardive Dyskinesia Task Force Report 18","year":"1981","author":"Baldesserini RJ","key":"e_1_2_1_6_2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199106000-00013"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.850"},{"key":"e_1_2_1_9_2","first-page":"261","article-title":"Calcium\u2010entry blockers\u2010induced parkinsonism: possible role of inherited susceptibility","volume":"13","author":"Negrotti A","year":"1992","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199104000-00005"},{"key":"e_1_2_1_11_2","first-page":"41","volume-title":"Drug\u2010induced movement disorders","author":"Friedman JH","year":"1992"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290040080014"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870120119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870120119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:09:54Z","timestamp":1760958594000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870120119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1002\/mds.870120119"],"URL":"https:\/\/doi.org\/10.1002\/mds.870120119","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}