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Stimulating the digital nerves of the middle finger caused exaggerated reflex activity in the first dorsal interosseus (FDI) muscle of that hand with a latency of 46\u201351 ms. Magnetic stimulation over the contralateral cortex, delivered 25 ms after the digital nerve stimulus, resulted in greater than expected facilitation of FDI, implying spatial summation. Poststimulus time histograms (PSTH) of individual FDI motor units indicated that this spatial summation was occurring \u201cupstream\u201d from the motoneurons. It is argued that this occurs at the motor cortex. Magnetic stimulation over the cortex in normal subjects results in short\u2010latency facilitation of the contralateral motoneurons followed by inhibition. This inhibition was less in the patients with CBGD. It is argued that this results from the loss of an intrinsic cortical or corticothalamic inhibitory mechanism.<\/jats:p>","DOI":"10.1002\/mds.870120315","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:20:30Z","timestamp":1117311630000},"page":"360-369","source":"Crossref","is-referenced-by-count":32,"title":["Reflex myoclonus in cortical\u2010basal ganglionic degeneration involves a transcortical pathway"],"prefix":"10.1002","volume":"12","author":[{"given":"A.","family":"Strafella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ashby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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