{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:14:02Z","timestamp":1763036042538,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2744,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This exploratory study was meant to determine the effect of the dopamine (DA) agonist pergolide on Gilles de la Tourette syndrome (GTS) in children and adolescents and to ascertain correlates of pergolide response. Thirty\u2010two outpatients, aged 7\u201319 years, were systematically assessed in a neuropsychiatric clinic for the presence of GTS and comorbid disorders. After a 6\u2010week open\u2010label, fixed\u2010flexible dosing schedule, response to pergolide on standard GTS severity outcome measures was assessed. Overall, 75% of patients (24\/32) had a &gt;50% drop in their tic severity rating from baseline with a mean treatment dosage of 177 \u00b1 61 \u03bcg\/day. Highly significant (p = 0.0001) baseline to week 6 differences were demonstrated in all tic symptom measures. The presence of restless legs syndrome (RLS) comorbidity (59%) was highly associated with a positive response. These results suggest DA agonism as a strategy, and pergolide in particular, may be a practical form of therapy for GTS. Response predictors of patient comorbid RLS argue for its further study with regard to GTS.<\/jats:p>","DOI":"10.1002\/mds.870120320","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:20:30Z","timestamp":1117311630000},"page":"402-407","source":"Crossref","is-referenced-by-count":66,"title":["Dopamine agonist treatment of tourette disorder in children: Results of an open\u2010label trial of pergolide"],"prefix":"10.1002","volume":"12","author":[{"given":"Joseph F.","family":"Lipinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floyd R.","family":"Sallee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherry","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopalan","family":"Sethuraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810080052006"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.5.621"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1993.3.137"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810280040006"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.95.1.74"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199304000-00009"},{"key":"e_1_2_1_8_2","first-page":"267","volume-title":"Handbook of Tourette's syndrome and other related tic and behavioral disorders","author":"Singer HS","year":"1993"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199309000-00025"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1994.tb02661.x"},{"key":"e_1_2_1_11_2","first-page":"739","article-title":"Restless legs syndrome and sleep bruxism: prevalence and association among Canadians","volume":"17","author":"Lavigne GJ","year":"1995","journal-title":"Sleep"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.92"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.156.3.243"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mds.870100517","article-title":"International Restless Legs Syndrome Study Group. 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