{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:04Z","timestamp":1761007444349,"version":"build-2065373602"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2621,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multicase families are frequently utilized in studies of movement disorders (MDs). We report families with two or more MD cases seen at the Movement Disorder Clinic, Saskatoon (MDCS). In 30% of the MD probands, there was either a history or documentation of at least one secondary MD case in the family. Only those MD cases that were seen at the MDCS were considered in this study. A total of 56 probands and 77 secondary MD cases were seen at the MDCS between 1968 and 1996. In 24 (31.2%) of the secondary cases, the diagnosis was different from that in the proband. In 46 families (82%), only one secondary case was seen, and the diagnosis was concordant with the proband in 71.7%. In the remaining 10 families with two or more secondary cases, the diagnosis was concordant in 64.5% of cases. The largest subgroup was Parkinson's disease (PD)\u201440 probands and 53 secondary cases. Of these secondary cases, 73.6% had PD. The concordance rate was 91% in essential tremor, but only 12.5% if the proband had essential tremor + parkinsonism. Considering that a large proportion of secondary cases have a diagnosis discordant with the proband, we recommend that, wherever possible, MD diagnosis in secondary cases be based on clinical assessment.<\/jats:p>","DOI":"10.1002\/mds.870120520","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:28:34Z","timestamp":1117312114000},"page":"747-751","source":"Crossref","is-referenced-by-count":5,"title":["Concordance of common movement disorders among familial cases"],"prefix":"10.1002","volume":"12","author":[{"given":"A. H.","family":"Rajput","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.8.1218"},{"key":"e_1_2_1_3_2","first-page":"307","volume-title":"Advances in neurology","author":"Duvoisin RC","year":"1987"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S0317167100026664","article-title":"Familial Parkinson's disease: possible role of environmental factors","volume":"14","author":"Calne S","year":"1987","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_5_2","first-page":"480","article-title":"Parkinson's disease in two generations: possible etiology [Abstract]","volume":"9","author":"Rajput AH","year":"1994","journal-title":"Mov Disord"},{"issue":"1","key":"e_1_2_1_6_2","first-page":"S15","article-title":"Lewy body Parkinson's disease in a large kindred [Abstract]","volume":"22","author":"Rajput AH","year":"1995","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199408000-00011"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.4.805"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320303"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.645"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360310"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060303"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270309"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350110"},{"issue":"3","key":"e_1_2_1_15_2","first-page":"7","article-title":"The genetics of Parkinson's disease: a reconsideration","volume":"40","author":"Golbe LI","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.3.502"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360514"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.2.283"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.7.815"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870050302"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380306"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.3.443"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.3_Part_1.499"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100044541"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.3.495"},{"key":"e_1_2_1_28_2","first-page":"465","article-title":"Parkinson's disease: genetic analysis and evidence of a multifactorial etiology","volume":"48","author":"Kondo K","year":"1973","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_29_2","first-page":"2222","article-title":"Autosomal dominant parkinsonism with benign course and typical Lewy\u2010body pathology","volume":"43","author":"Golbe LI","year":"1993","journal-title":"Neurology"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100036362"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110148"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100031814"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.9.1422"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00029679-199517060-00001"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710004765X"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.5.746"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610163151604"},{"key":"e_1_2_1_40_2","first-page":"337","volume-title":"Handbook of Toarette's syndrome and related tic and behavioral disorders","author":"Tanner CM","year":"1993"},{"key":"e_1_2_1_41_2","first-page":"11","article-title":"Epidemiologic and genetic characteristics of parkinsonism: a review","volume":"2","author":"Kurland LT","year":"1961","journal-title":"Int J Neurol"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100039469"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91196-F"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.8.911"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199410000-00014"},{"key":"e_1_2_1_46_2","first-page":"290","article-title":"Allelic frequencies of tyrosine hydroxylase in Parkinson's disease patients [Abstract]","volume":"7","author":"Kurth JH","year":"1992","journal-title":"Mov Disord"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330406"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370318"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90537-D"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090312"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260606"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.344"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.7.734"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240106"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190318"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.3.362"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.4.659"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170404"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1894"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870120520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870120520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:09:49Z","timestamp":1760965789000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870120520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1002\/mds.870120520"],"URL":"https:\/\/doi.org\/10.1002\/mds.870120520","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}