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Three of the nine SRO patients had a so\u2010called \u201ceye of the tiger sign\u201d with high signal in the globus pallidus surrounded by a ring of low signal on T2 weighted magnetic resonance imaging previously only reported in Hallervorden\u2010Spatz disease. One of these patients had pathologically proven SRO at postmortem. The SRO group showed a significant reduction in the median concentration from <jats:italic>N<\/jats:italic>\u2010acetyl groups (median, 6.87 m<jats:italic>M<\/jats:italic>; range, 4.92\u201310.59 m<jats:italic>M<\/jats:italic>; p &lt; 0.015) compared with the control group (median, 9.85 m<jats:italic>M<\/jats:italic>; range, 9.26\u201311.0 m<jats:italic>M<\/jats:italic>). The <jats:italic>N<\/jats:italic>\u2010acetylaspartate concentration was significantly reduced in seven of the nine patients studied. The reduction of the <jats:italic>N<\/jats:italic>\u2010acetylaspartate\u2010creatine ratio from the lentiform nucleus in the SRO group may reflect neuronal loss, occurring predominantly in the globus pallidus. Proton magnetic resonance spectroscopy may be a useful, noninvasive technique to help differentiate the various parkinsonian syndromes.<\/jats:p>","DOI":"10.1002\/mds.870120525","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:28:34Z","timestamp":1117312114000},"page":"767-771","source":"Crossref","is-referenced-by-count":54,"title":["Proton magnetic resonance spectroscopy in steele\u2010richardson\u2010olszewski syndrome"],"prefix":"10.1002","volume":"12","author":[{"given":"Charles A.","family":"Davie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth J.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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