{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:13:24Z","timestamp":1784837604331,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2621,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Botulinum toxin (BTX) injection is considered the treatment of choice for patients with cervical dystonia (torticollis). We conducted a pilot, open\u2010label, dose\u2010escalation study with BTX type B in 12 patients who no longer responded clinically to injections with BTX type A. At the doses tested, BTX type B was safe and well tolerated without evidence of dose\u2010limiting toxicity in this patient population. Mild\u2010to\u2010moderate adverse events generally resolved quickly and included asthenia, pain, nausea, dysphagia, hypertonia, and tremor. No serious adverse events or antibodies to type\u2010B treatment were reported. Low\u2010dosing\u2010session (100\u2010\u2010899 units) and high\u2010dosing\u2010session (900\u20131,500 units) groups were defined based on units administered per dosing session. Toronto Western Spasmodic Torticollis Rating Scale\u2010Severity Scale (TWSTRS\u2010Severity), Patient Analogue Pain Scale, and Physician and Patient Global Assessment Scales were measured during this study. The TWSTRS\u2010Severity mean maximum percent improvement from baseline demonstrated a 9.9% versus 28.8% difference between the low\u2010dose and high\u2010dose groups, respectively. Effectiveness was noted for the high\u2010dose group on the Patient Analogue Pain Scale but not on the Global Assessment Scales.<\/jats:p>","DOI":"10.1002\/mds.870120526","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:28:34Z","timestamp":1117312114000},"page":"772-775","source":"Crossref","is-referenced-by-count":26,"title":["BotB (botulinum Toxin type B): Evaluation of safety and tolerability in botulinum toxin type A\u2010Resistant cervical dystonia patients (preliminary study)"],"prefix":"10.1002","volume":"12","author":[{"given":"Daniel D.","family":"Truong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Cullis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","volume-title":"Dystonia II","author":"Fahn S","year":"1988"},{"key":"e_1_2_1_3_2","first-page":"317","volume-title":"Handbook of dystonia","author":"Fahn S","year":"1995"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71399-6_2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090216"},{"key":"e_1_2_1_6_2","first-page":"211","volume-title":"Therapy with botulinum toxin","author":"Consky ES","year":"1994"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.11.2109"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1743"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870120526","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870120526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:09:57Z","timestamp":1760965797000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870120526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1002\/mds.870120526"],"URL":"https:\/\/doi.org\/10.1002\/mds.870120526","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}