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Psychiatric symptoms included psychosis and depression, with onset years before the movement disorder. After his death by aspiration, examination of his brain revealed abnormalities limited to the neostriatum. Staining of brain sections, including Holzer, glial fibrillary acidic protein, and immunohistochemical stain for calbindin D28k, revealed the presence of a mosaic pattern of gliosis with neuronal loss (sparing large neurons) within this region. The islands of tissue between strands of gliosis had a normal appearance. This patient represents only the fourth case (and first North American born) with a mosaic pattern of gliosis in the neostriatum. The clinical and pathologic features were similar in all four cases except that our patient was the first with prominent psychiatric symptoms and a more stable, less progressive course. Mosaicism has been described in the X\u2010linked Filipino disorder <jats:italic>Lubag<\/jats:italic>. Occurrence in non\u2010Filipino patients, such as ours, suggests that either Lubag can develop in non\u2010Filipino families or that mosaicism is a nonspecific pathologic finding in some patients with idiopathic dystonia. Finally, our case supports the notion that craniocervical dystonia may result from neostriatal dysfunction.<\/jats:p>","DOI":"10.1002\/mds.870120528","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:28:34Z","timestamp":1117312114000},"page":"783-789","source":"Crossref","is-referenced-by-count":16,"title":["Mosaic pattern of gliosis in the neostriatum of a north american man with craniocervical dystonia and parkinsonism"],"prefix":"10.1002","volume":"12","author":[{"given":"Stewart A.","family":"Factor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin 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