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Genetic loci on chromosome <jats:italic>2p22\u2010p25<\/jats:italic> establish linkage to this region with a maximum LOD score (Z<jats:sub>max<\/jats:sub>) = 5.92 for the locus, <jats:italic>D2S272<\/jats:italic>. Obligate recombinant events place the <jats:italic>ETM<\/jats:italic> gene in a 15\u2010cM candidate interval between the genetic loci <jats:italic>D2S168<\/jats:italic> and <jats:italic>D2S224<\/jats:italic>. Repeat expansion detection analysis suggests that expanded CAG trinucleotide sequences are associated with ET. These findings will facilitate the search for an <jats:italic>ETM<\/jats:italic> gene and may further our understanding of the human motor system.<\/jats:p>","DOI":"10.1002\/mds.870120605","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:33:54Z","timestamp":1117312434000},"page":"859-864","source":"Crossref","is-referenced-by-count":185,"title":["A gene (<i>ETM<\/i>) for essential tremor maps to chromosome <i>2p22\u2010p25<\/i>"],"prefix":"10.1002","volume":"12","author":[{"given":"Joseph J.","family":"Higgins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana T.","family":"Pho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda 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