{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:28:57Z","timestamp":1791134937284,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2560,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the cases of 55 patients with parkinsonism and prior dopaminomimetic therapy in whom the response to this treatment was questionable or reported to be negative. None of these patients had shown motor fluctuations prior to this study. We compared the results of imaging of dopamine\u2010D2 receptors by using [<jats:sup>123<\/jats:sup>l]iodobenzamide\u2010single\u2010photon\u2010emission computed tomography (IBZM\u2010SPECT) with the improvement in motor signs following a subcutaneous injection of apomorphine and a subsequent increase in oral dopaminomimetic therapy. IBZM\u2010SPECT accurately predicted a positive or negative response to apomorphine in 37 (84%) of 44 patients. The sensitivity\/specificity was calculated as 96.3%\/64.7%. The sensitivity\/specificity of IBZM\u2010SPECT for the response to oral treatment with levodopa (L\u2010dopa) was calculated as 100%\/75%. After a follow\u2010up period of 2\u20134 years, 25 patients developed motor fluctuations. All of these patients had normal IBZM binding. Nine developed clinical signs indicating a basal ganglia disorder other than Parkinson's disease. Eight of these nine patients had reduced, and one patient had normal, IBZM binding. We conclude that normal IBZM binding is a useful predictor of a good response to dopaminergic drugs in patients with parkinsonism and a questionable response to previous dopaminomimetic therapy. Reduced IBZM binding seems to exclude a diagnosis of Parkinson's disease, because none of the latter patients clearly benefited from L\u2010dopa and 66.7% developed clinical signs indicating another disorder of the basal ganglia.<\/jats:p>","DOI":"10.1002\/mds.870120610","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:33:54Z","timestamp":1117312434000},"page":"898-902","source":"Crossref","is-referenced-by-count":32,"title":["[<sup>123<\/sup>]IBZM Binding predicts dopaminergic responsiveness in patients with parkinsonism and previous dopaminomimetic therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Johannes","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H.","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.556"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.Suppl.78"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540050063017"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.4.835"},{"key":"e_1_2_1_6_2","first-page":"1112","article-title":"123I\u2010IBZM binding in patients with parkinsonism: reduction by dopamine agonists but not L\u2010dopa","volume":"37","author":"Schwarz J","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199108000-00005"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530350045017"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.11.1723"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92354-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1325"},{"issue":"6","key":"e_1_2_1_12_2","first-page":"17","article-title":"123I\u2010Iodobenzamide\u2010SPECT in 83 patients with de novo parkinsonism","volume":"43","author":"Schwarz J","year":"1993","journal-title":"Neurology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080406"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.53"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100040889"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.1.98"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.9.1047"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30218-4"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.870120610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.870120610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:38:51Z","timestamp":1760956731000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.870120610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1002\/mds.870120610"],"URL":"https:\/\/doi.org\/10.1002\/mds.870120610","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}