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The study assessed the level of N\u2010acetylaspartate (NAA), creatine\u2013phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA\/Cho and NAA\/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. <jats:sup>1<\/jats:sup>H\u2010MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.<\/jats:p>","DOI":"10.1002\/mds.870120611","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:33:54Z","timestamp":1117312434000},"page":"903-909","source":"Crossref","is-referenced-by-count":63,"title":["Proton magnetic resonance spectroscopy in parkinson's disease and atypical parkinsonian disorders"],"prefix":"10.1002","volume":"12","author":[{"given":"Francesco","family":"Federico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella 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