{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:52:05Z","timestamp":1789620725823,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":2440,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is increasing evidence that a dysfunction of the dopaminergic system may be involved in the pathogenesis of idiopathic dystonia. To visualize possible alterations of the pre\u2010 and postsynaptic side of striatal dopaminergic synapses, SPECT studies using the radiotracers [<jats:sup>123<\/jats:sup>I] epidepride and [<jats:sup>123<\/jats:sup>I] \u03b2\u2010CIT were performed in 10 patients with idiopathic cervical dystonia. Eleven age\u2010 and sex\u2010matched subjects served as controls. [<jats:sup>123<\/jats:sup>I] Epidepride is a new highly affine marker of D2 receptors, and [<jats:sup>123<\/jats:sup>I] \u03b2\u2010CIT binds to dopamine transporters on dopaminergic nerve endings. [<jats:sup>123<\/jats:sup>I] Epidepride binding was significantly reduced in both striata of dystonia patients compared with controls (p &lt; 0.05). In contrast, striatal [<jats:sup>123<\/jats:sup>I] \u03b2\u2010CIT uptake did not differ from controls. We conclude that dopaminergic dysfunction in idiopathic focal dystonia mainly involves postsynaptic mechanisms and suggest a disturbance of the indirect pathway of the motor circuit resulting in a disinhibited thalamocortical stimulation.<\/jats:p>","DOI":"10.1002\/mds.870130219","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T20:40:51Z","timestamp":1117312851000},"page":"319-323","source":"Crossref","is-referenced-by-count":144,"title":["Imaging the pre\u2010 and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: A SPECT STUDY Using [<sup>123<\/sup>I] epidepride and [<sup>123<\/sup>I] 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