{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:37:34Z","timestamp":1790631454987,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance\u2013guided focused ultrasound is an emerging, minimally invasive thermoablation technique for medically refractory essential tremor. Beyond the initial year, data regarding efficacy and potential predictors of efficacy are still preliminary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to assess the outcome at 2 years and the association between lesion volume and outcome 1 year after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed data from 37 patients who underwent unilateral magnetic resonance\u2013guided focused ultrasound thalamotomy, with primary outcome being dominant tremor subscore of the Clinical Rating Scale for Tremor. We used multivariable linear regression to model initial lesion volume with 1\u2010year outcome, adjusting for other clinically relevant variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although we detected a trend in loss of clinical benefit within the first year, the dominant tremor score at 2 years continued to be significantly improved (43.4%, 95% confidence interval 27.8%\u201059.0%) from baseline. Secondarily, initial lesion volume is significantly associated with 1\u2010year outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show that magnetic resonance\u2013guided focused ultrasound thalamotomy results in sustained tremor reduction for medically refractory essential tremor even in the long term, and we highlight areas for improvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.99","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T23:23:49Z","timestamp":1538781829000},"page":"1647-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Magnetic resonance\u2013guided focused ultrasound thalamotomy for treatment of essential tremor: A 2\u2010year outcome study"],"prefix":"10.1002","volume":"33","author":[{"given":"Ying","family":"Meng","sequence":"first","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boutet","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheleth","family":"Llinas","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Division of Neurosurgery Toronto Western Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Scantlebury","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexi","family":"Huang","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kullervo","family":"Hynynen","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Hamani","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Fasano","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto  Toronto Ontario Canada"},{"name":"Krembil Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Krembil Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Lipsman","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.1.JNS121111"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478866"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.3.JNS112316"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/17\/R206"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25126"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26455"},{"key":"e_1_2_7_9_1","article-title":"Transcranial MRI\u2010guided high\u2010intensity focused ultrasound for treatment of essential tremor: a pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome","author":"Federau C","year":"2017","journal-title":"J Magn Reson Imaging"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.3.JNS142592"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3808"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003795"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.FOCUS17587"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099851"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.8.1194"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22570"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.99","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:16:30Z","timestamp":1760962590000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/mds.99"],"URL":"https:\/\/doi.org\/10.1002\/mds.99","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}