{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:39:34Z","timestamp":1791322774221,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T00:00:00Z","timestamp":1228262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The zinc enzymes carbonic anhydrases (CAs, EC 4.2.1.1) are very efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate and hence play an important physiological role. In humans, 16 different isozymes have been described, some of them being involved in various pathological disorders. Several of these isozymes are considered as drug targets, and the design of selective inhibitors is a long\u2010standing goal that has captured the attention of researchers for 40 years and has lead to clinical applications against different pathologies such as glaucoma, epilepsy, and cancer. Among the different strategies developed for designing selective CA inhibitors (CAIs), the \u201csugar approach\u201d has recently emerged as a new attractive and versatile tool. Incorporation of glycosyl moieties in different aromatic\/heterocyclic sulfonamide\/sulfamides\/sulfamates scaffolds has led to the development of numerous and very effective inhibitors of potential clinical value. The clinical use of a highly active carbohydrate\u2010based CA inhibitor, i.e., topiramate, constitutes an interesting demonstration of the validity of this approach. Other carbohydrate\u2010based compounds also demonstrate promising potential for the treatment of ophthalmologic diseases. This review will focus on the development of this emerging sugar\u2010based approach for the development of CAIs. \u00a9 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 3, 419\u2010435, 2009<\/jats:p>","DOI":"10.1002\/med.20141","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T20:41:45Z","timestamp":1228336905000},"page":"419-435","source":"Crossref","is-referenced-by-count":107,"title":["Therapeutic applications of glycosidic carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"29","author":[{"given":"Jean\u2010Yves","family":"Winum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally\u2010Ann","family":"Poulsen,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527618255"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/3527602437"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/3527601740"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802607780636690"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","DOI":"10.4324\/9780203475300","volume-title":"Carbonic anhydrase\u2014Its inhibitors and activators","author":"Supuran CT","year":"2004"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.10025"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783877848"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802607780636771"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/138955706777934946"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20068"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20021"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.04.020"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.16.12.1627"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756360410001689540"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767150-00008"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/138955708783331568"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783877956"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.6.968a"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.07.003"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00388a023"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm040124c"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm058279n"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm060807n"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.02.008"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of carbonic anhydrase. 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