{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:43:11Z","timestamp":1791132191247,"version":"4.1.0"},"reference-count":359,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As the major etiological agent of the common cold, human rhinoviruses (HRV) cause millions of lost working and school days annually. Moreover, clinical studies proved an association between harmless upper respiratory tract infections and more severe diseases e.g. sinusitis, asthma, and chronic obstructive pulmonary disease. Both the medicinal and socio\u2010economic impact of HRV infections and the lack of antiviral drugs substantiate the need for intensive antiviral research. A common structural feature of the approximately 100 HRV serotypes is the icosahedrally shaped capsid formed by 60 identical copies of viral capsid proteins VP1\u20104. The capsid protects the single\u2010stranded, positive sense RNA genome of about 7,400 bases in length. Both structural as well as nonstructural proteins produced during the viral life cycle have been identified as potential targets for blocking viral replication at the step of attachment, entry, uncoating, RNA and protein synthesis by synthetic or natural compounds. Moreover, interferon and phytoceuticals were shown to protect host cells. Most of the known inhibitors of HRV replication were discovered as a result of empirical or semi\u2010empirical screening in cell culture. Structure\u2013activity relationship studies are used for hit optimization and lead structure discovery. The increasing structural insight and molecular understanding of viral proteins on the one hand and the advent of innovative computer\u2010assisted technologies on the other hand have facilitated a rationalized access for the discovery of small chemical entities with antirhinoviral (anti\u2010HRV) activity. This review will (i) summarize existing structural knowledge about HRV, (ii) focus on mechanisms of anti\u2010HRV agents from synthetic and natural origin, and (iii) demonstrate strategies for efficient lead structure discovery. \u00a9 2009 Wiley Periodicals, Inc. Med Res Rev, 31, No. 1, 42\u201392, 2010<\/jats:p>","DOI":"10.1002\/med.20176","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T17:21:41Z","timestamp":1251393701000},"page":"42-92","source":"Crossref","is-referenced-by-count":68,"title":["The human rhinovirus: human\u2010pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery"],"prefix":"10.1002","volume":"31","author":[{"given":"Judith M.","family":"Rollinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schmidtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-008-0041-x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1406.080271"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-4-40"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01254-07"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.03.012"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001847"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165557"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1170-1174.2000"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.1941-1948.1999"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.5.1288-1293.1999"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-10-2549"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.7.3663-3674.2004"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.3.732"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2605"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.9.5363-5373.2005"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-1-49"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01702661"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.6.2111"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.20.7859"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-224"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-2-333"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12162-9"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00016-3"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000966"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/525542"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/524312"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800050779"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70127-7"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1502.081468"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/431982"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01234.x"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.35.11.2864-2868.1997"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.2.539-542.1998"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80093-5"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.08.036"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2140"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318182c90a"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/313937"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.1033"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f470ac"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.6.9196088"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1086\/598627"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/374340"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.11.009"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-489OC"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000162308.89857.6c"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1621OC"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d19.x"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041901"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-008-0197-0"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.06.006"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-007-1117-1"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.025"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2105011"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d19.x"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0509-9"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.2.117"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.12.002"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080386"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.007"},{"key":"e_1_2_9_62_2","first-page":"194","article-title":"Rhinovirus transmission: one if by air, two if by hand","volume":"89","author":"Gwaltney JM","year":"1978","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021771"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20956"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.3.442"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-4-463"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113473"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.6.811"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(01)00213-3"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki329"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.5.1329"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09112250"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9117003"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2003019"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488409128537"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380130091034"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.6.1287"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-970OC"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1086\/315513"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.075077"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00006"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1086\/431588"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1086\/422996"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1086\/513922"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31814847d9"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90169-3"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0166-3"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1994.tb00934.x"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.6.1267"},{"key":"e_1_2_9_90_2","first-page":"879","article-title":"Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects","volume":"151","author":"Fraenkel DJ","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/152.4_Pt_2.S40"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113843"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-116"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804181105"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.4.487"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.03.011"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1086\/322627"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00281-4"},{"key":"e_1_2_9_99_2","first-page":"796","volume-title":"Fields virology","author":"Racaniello VR","year":"2007"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(90)90076-X"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(97)00199-8"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(89)90293-3"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/0969-2126(93)90008-5"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/317145a0"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3943"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(96)00128-1"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.1989.2.143"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560031010"},{"key":"e_1_2_9_109_2","first-page":"531","article-title":"Crystallographic and cryo EM analysis of virion\u2010receptor interactions","volume":"9","author":"Rossmann MG","year":"1994","journal-title":"Arch Virol Suppl"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90689-2"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7389-7395.2005"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.5.1839"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806451105"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.22.6249"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6317"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90098-V"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02160-06"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.5963-5970.2005"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004300050039"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.19.9312-9319.2001"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.2.1085-1092.1995"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.2.1354-1364.1998"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2935-2942.2004"},{"key":"e_1_2_9_124_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.1.390-397.1993"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.9.5370-5377.2003"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.6.3713-3723.1994"},{"key":"e_1_2_9_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb753"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1989.tb14862.x"},{"key":"e_1_2_9_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90042-1"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.12.8444-8450.1996"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00080a033"},{"key":"e_1_2_9_132_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1089"},{"key":"e_1_2_9_133_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.619-626.2005"},{"key":"e_1_2_9_134_2","first-page":"895","volume-title":"Fields virology","author":"Turner RB","year":"2007"},{"key":"e_1_2_9_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20315"},{"key":"e_1_2_9_136_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0050OC"},{"key":"e_1_2_9_137_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00300.2003"},{"key":"e_1_2_9_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(88)90020-4"},{"key":"e_1_2_9_139_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00398a009"},{"key":"e_1_2_9_140_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.6.883"},{"key":"e_1_2_9_141_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.3.1117-1123.1990"},{"key":"e_1_2_9_142_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0202876"},{"key":"e_1_2_9_143_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1766-1772.2004"},{"key":"e_1_2_9_144_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki055"},{"key":"e_1_2_9_145_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm701494b"},{"key":"e_1_2_9_146_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00905-07"},{"key":"e_1_2_9_147_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-11-2335"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1243OC"},{"key":"e_1_2_9_149_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1713"},{"key":"e_1_2_9_150_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.6.892"},{"key":"e_1_2_9_151_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.2.174"},{"key":"e_1_2_9_152_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.6.1004"},{"key":"e_1_2_9_153_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.5.671"},{"key":"e_1_2_9_154_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.2.297"},{"key":"e_1_2_9_155_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1708-1709.2000"},{"key":"e_1_2_9_156_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776361129"},{"key":"e_1_2_9_157_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20125"},{"key":"e_1_2_9_158_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026043387836"},{"key":"e_1_2_9_159_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.57.1.7-12.1986"},{"key":"e_1_2_9_160_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.41.24078"},{"key":"e_1_2_9_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(88)90055-1"},{"key":"e_1_2_9_162_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh019"},{"key":"e_1_2_9_163_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1425"},{"key":"e_1_2_9_164_2","doi-asserted-by":"publisher","DOI":"10.1038\/344070a0"},{"key":"e_1_2_9_165_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1413"},{"key":"e_1_2_9_166_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.50.33835"},{"key":"e_1_2_9_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.05.016"},{"key":"e_1_2_9_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.013"},{"key":"e_1_2_9_169_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.6.1186"},{"key":"e_1_2_9_170_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.11.6015-6023.1991"},{"key":"e_1_2_9_171_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.6.3561-3568.1993"},{"key":"e_1_2_9_172_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.9.695"},{"key":"e_1_2_9_173_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.4.9105055"},{"key":"e_1_2_9_174_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.19.1797"},{"key":"e_1_2_9_175_2","first-page":"1","article-title":"Inhibitors of picornavirus replication","volume":"2","author":"Diana GD","year":"2003","journal-title":"Curr Med Chem"},{"key":"e_1_2_9_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(89)90016-8"},{"key":"e_1_2_9_177_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.20.11061-11069.2004"},{"key":"e_1_2_9_178_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340060102"},{"key":"e_1_2_9_179_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.5.2002-2007.1989"},{"key":"e_1_2_9_180_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3018924"},{"key":"e_1_2_9_181_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1137"},{"key":"e_1_2_9_182_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.14730"},{"key":"e_1_2_9_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(94)90094-9"},{"key":"e_1_2_9_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(00)00106-6"},{"key":"e_1_2_9_185_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2109"},{"key":"e_1_2_9_186_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki263"},{"key":"e_1_2_9_187_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01310997"},{"key":"e_1_2_9_188_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.1.100"},{"key":"e_1_2_9_189_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0704806"},{"key":"e_1_2_9_190_2","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1128\/AAC.41.6.1220","article-title":"SCH 48973: A potent, broad\u2010spectrum, antienterovirus compound","volume":"41","author":"Buontempo PJ","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_9_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(95)00979-5"},{"key":"e_1_2_9_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(93)90064-P"},{"key":"e_1_2_9_193_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.4.617"},{"key":"e_1_2_9_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(90)90022-Y"},{"key":"e_1_2_9_195_2","doi-asserted-by":"publisher","DOI":"10.1038\/292369a0"},{"key":"e_1_2_9_196_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00159a006"},{"key":"e_1_2_9_197_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.3.516"},{"key":"e_1_2_9_198_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00153a020"},{"key":"e_1_2_9_199_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.4.639"},{"key":"e_1_2_9_200_2","first-page":"3","article-title":"Application of crystallography to the design of antiviral agents","volume":"1","author":"Rossmann MG","year":"1992","journal-title":"Infect Agents Dis"},{"key":"e_1_2_9_201_2","doi-asserted-by":"publisher","DOI":"10.1086\/315176"},{"key":"e_1_2_9_202_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/135965350200700107","article-title":"Oral pleconaril treatment of picornavirus\u2010associated viral respiratory illness in adults: Efficacy and tolerability in phase II clinical trials","volume":"7","author":"Hayden FG","year":"2002","journal-title":"Antivir Ther"},{"key":"e_1_2_9_203_2","doi-asserted-by":"publisher","DOI":"10.1086\/375069"},{"key":"e_1_2_9_204_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.11.4492-4499.2005"},{"key":"e_1_2_9_205_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005283286"},{"key":"e_1_2_9_206_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.4.727"},{"key":"e_1_2_9_207_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.13892-13899.2005"},{"key":"e_1_2_9_208_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.18.2276"},{"key":"e_1_2_9_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80003-5"},{"key":"e_1_2_9_210_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119702"},{"key":"e_1_2_9_211_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-003-0198-6"},{"key":"e_1_2_9_212_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9808043"},{"key":"e_1_2_9_213_2","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1128\/jvi.67.8.4688-4695.1993","article-title":"Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase\u2010specific inhibitors","volume":"67","author":"Molla A","year":"1993","journal-title":"J Virol"},{"key":"e_1_2_9_214_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00612-06"},{"key":"e_1_2_9_215_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00069-9"},{"key":"e_1_2_9_216_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.916"},{"key":"e_1_2_9_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90059-0"},{"key":"e_1_2_9_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.12.059"},{"key":"e_1_2_9_219_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11000"},{"key":"e_1_2_9_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.12.030"},{"key":"e_1_2_9_221_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm980068d"},{"key":"e_1_2_9_222_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9800696"},{"key":"e_1_2_9_223_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm010469k"},{"key":"e_1_2_9_224_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm980537b"},{"key":"e_1_2_9_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00008-2"},{"key":"e_1_2_9_226_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm030166l"},{"key":"e_1_2_9_227_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9805384"},{"key":"e_1_2_9_228_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.10.2444"},{"key":"e_1_2_9_229_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.5.1236-1241.2000"},{"key":"e_1_2_9_230_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.392-397.2002"},{"key":"e_1_2_9_231_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3907-3916.2003"},{"key":"e_1_2_9_232_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2267-2275.2005"},{"key":"e_1_2_9_233_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.03.064"},{"key":"e_1_2_9_234_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00011-08"},{"key":"e_1_2_9_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2003.08.005"},{"key":"e_1_2_9_236_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2003.10.004"},{"key":"e_1_2_9_237_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969786"},{"key":"e_1_2_9_238_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.12.6004-6015.2002"},{"key":"e_1_2_9_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90120-T"},{"key":"e_1_2_9_240_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/095632029200300606","article-title":"In vitro antiviral activity of ribavirin against picornaviruses","volume":"6","author":"Andersen DO","year":"1992","journal-title":"Antivir Chem Chemother"},{"key":"e_1_2_9_241_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20153"},{"key":"e_1_2_9_242_2","doi-asserted-by":"publisher","DOI":"10.1038\/82191"},{"key":"e_1_2_9_243_2","first-page":"651","article-title":"Ribavirin: Recent insights into antiviral mechanisms of action","volume":"4","author":"Reyes GR","year":"2001","journal-title":"Curr Opin Drug Disc"},{"key":"e_1_2_9_244_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/141.1.87"},{"key":"e_1_2_9_245_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00178a004"},{"key":"e_1_2_9_246_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.4.595"},{"key":"e_1_2_9_247_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.7.4189-4197.1995"},{"key":"e_1_2_9_248_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.7.4854-4857.1996"},{"key":"e_1_2_9_249_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050611"},{"key":"e_1_2_9_250_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.1.102"},{"key":"e_1_2_9_251_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92520-4"},{"key":"e_1_2_9_252_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.6.890"},{"key":"e_1_2_9_253_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9810405"},{"key":"e_1_2_9_254_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00193-6"},{"key":"e_1_2_9_255_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm960718i"},{"key":"e_1_2_9_256_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm970302k"},{"key":"e_1_2_9_257_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.Supplement_2.A136"},{"key":"e_1_2_9_258_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1983.3.425"},{"key":"e_1_2_9_259_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1989.9.285"},{"key":"e_1_2_9_260_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.26.1.31"},{"key":"e_1_2_9_261_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.3.543"},{"key":"e_1_2_9_262_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1986.6.153"},{"key":"e_1_2_9_263_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(83)90034-7"},{"key":"e_1_2_9_264_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.3.535"},{"key":"e_1_2_9_265_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.2.181"},{"key":"e_1_2_9_266_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1988.8.591"},{"key":"e_1_2_9_267_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.3.387"},{"key":"e_1_2_9_268_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.5.1173"},{"key":"e_1_2_9_269_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(86)90005-7"},{"key":"e_1_2_9_270_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(88)90022-8"},{"key":"e_1_2_9_271_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci0200467"},{"key":"e_1_2_9_272_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci050031j"},{"key":"e_1_2_9_273_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-005-1297-7"},{"key":"e_1_2_9_274_2","doi-asserted-by":"publisher","DOI":"10.1021\/np068054v"},{"key":"e_1_2_9_275_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527609987.ch15"},{"key":"e_1_2_9_276_2","doi-asserted-by":"publisher","DOI":"10.2174\/1385272033486558"},{"key":"e_1_2_9_277_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2174\/1385272801666220126154627","article-title":"Plant substances as antiviral agents","volume":"1","author":"Vlietinck AJ","year":"1997","journal-title":"Curr Org Chem"},{"key":"e_1_2_9_278_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0703315"},{"key":"e_1_2_9_279_2","first-page":"63","article-title":"Herb sales down 6 percent in mainstream market","volume":"66","author":"Blumenthal M","year":"2005","journal-title":"Herbal Gram"},{"key":"e_1_2_9_280_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993766"},{"key":"e_1_2_9_281_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000530.pub2"},{"key":"e_1_2_9_282_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70160-3"},{"key":"e_1_2_9_283_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.02.001"},{"key":"e_1_2_9_284_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981531"},{"key":"e_1_2_9_285_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601074200"},{"key":"e_1_2_9_286_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0502395"},{"key":"e_1_2_9_287_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1824"},{"key":"e_1_2_9_288_2","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-110"},{"key":"e_1_2_9_289_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850113"},{"key":"e_1_2_9_290_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961504"},{"key":"e_1_2_9_291_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209309082936"},{"key":"e_1_2_9_292_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2006.12.153"},{"key":"e_1_2_9_293_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1041470"},{"key":"e_1_2_9_294_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2186"},{"key":"e_1_2_9_295_2","doi-asserted-by":"publisher","DOI":"10.5142\/JGR.2008.32.3.264"},{"key":"e_1_2_9_296_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.04.003"},{"key":"e_1_2_9_297_2","first-page":"202","article-title":"Inhibitory effect of ginseng polysaccharides on rotavirus infection","volume":"14","author":"Bae E\u2010A","year":"2004","journal-title":"J Microbiol Biotechnol"},{"key":"e_1_2_9_298_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209509088139"},{"key":"e_1_2_9_299_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2003.12.004"},{"key":"e_1_2_9_300_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(86)90031-0"},{"key":"e_1_2_9_301_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(00)00249-9"},{"key":"e_1_2_9_302_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.09.011"},{"key":"e_1_2_9_303_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707135"},{"key":"e_1_2_9_304_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2007.09.004"},{"key":"e_1_2_9_305_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006323.pub2"},{"key":"e_1_2_9_306_2","first-page":"77","article-title":"Traditionally used pelargonium species: Chemistry and biological activity of umckaloabo extracts and their constituents","volume":"3","author":"Kolodziej H","year":"2000","journal-title":"Curr Top Phytochem"},{"key":"e_1_2_9_307_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993778"},{"key":"e_1_2_9_308_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.06.009"},{"key":"e_1_2_9_309_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.07.001"},{"key":"e_1_2_9_310_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.9.1388"},{"key":"e_1_2_9_311_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-107"},{"key":"e_1_2_9_312_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.12.020"},{"key":"e_1_2_9_313_2","first-page":"42","volume-title":"Ethnobotany and the search for new drugs: Ciba Foundation Symposium 185","author":"Farnsworth NR","year":"1994"},{"key":"e_1_2_9_314_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026033392570"},{"key":"e_1_2_9_315_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.01.010"},{"key":"e_1_2_9_316_2","volume-title":"Pedanius Dioscorides of Anazarbus\u2014De materia medica","author":"Beck LYt","year":"2005"},{"key":"e_1_2_9_317_2","first-page":"766","article-title":"Sesquiterpene coumarins from Ferula assafoetida L","volume":"50","author":"Nassar MI","year":"1995","journal-title":"Pharmazie"},{"key":"e_1_2_9_318_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00050-1"},{"key":"e_1_2_9_319_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1088397"},{"key":"e_1_2_9_320_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.33.3881"},{"key":"e_1_2_9_321_2","first-page":"405","volume-title":"Bioactive Natural Products: Detection, Isolation and Structural Determination","author":"Vanden Berghe DAR","year":"1993"},{"key":"e_1_2_9_322_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00106a039"},{"key":"e_1_2_9_323_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac200577010007"},{"key":"e_1_2_9_324_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)92364-5"},{"key":"e_1_2_9_325_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00648-5"},{"key":"e_1_2_9_326_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.10.012"},{"key":"e_1_2_9_327_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.4.611"},{"key":"e_1_2_9_328_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.010"},{"key":"e_1_2_9_329_2","first-page":"521","article-title":"Antiviral activity of flavones and flavans","volume":"213","author":"Selway JWT","year":"1986","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_330_2","first-page":"283","article-title":"Present status and prospects of flavonoids as anti\u2010viral agents","volume":"280","author":"Vlietinck AJ","year":"1988","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_331_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-4-795"},{"key":"e_1_2_9_332_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/14.suppl_A.97"},{"key":"e_1_2_9_333_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01317482"},{"key":"e_1_2_9_334_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314131"},{"key":"e_1_2_9_335_2","doi-asserted-by":"publisher","DOI":"10.1002\/poc.597"},{"key":"e_1_2_9_336_2","doi-asserted-by":"publisher","DOI":"10.3390\/70800566"},{"key":"e_1_2_9_337_2","volume-title":"Methods and principles in medicinal chemistry","author":"Langer T","year":"2006"},{"key":"e_1_2_9_338_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(01)01990-0"},{"key":"e_1_2_9_339_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986708785132843"},{"key":"e_1_2_9_340_2","volume-title":"Neural networks for chemists","author":"Zupan J","year":"2000"},{"key":"e_1_2_9_341_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"e_1_2_9_342_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm8005977"},{"key":"e_1_2_9_343_2","article-title":"Development of antiviral agents using molecular modeling and virtual screening techniques","author":"Kirchmair J","year":"2009","journal-title":"J Infect Dis"},{"key":"e_1_2_9_344_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00226a005"},{"key":"e_1_2_9_345_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0896(96)00184-8"},{"key":"e_1_2_9_346_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00122a027"},{"key":"e_1_2_9_347_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00084a005"},{"key":"e_1_2_9_348_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00385a021"},{"key":"e_1_2_9_349_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.09.012"},{"key":"e_1_2_9_350_2","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1016\/S0021-9258(19)39096-9","article-title":"Site\u2010directed mutagenesis suggests close functional relationship between a human rhinovirus 3C cysteine protease and cellular trypsin\u2010like serine proteases","volume":"265","author":"Cheah KC","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_9_351_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560040801"},{"key":"e_1_2_9_352_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9903242"},{"key":"e_1_2_9_353_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm010469k"},{"key":"e_1_2_9_354_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-7743(08)61101-X"},{"key":"e_1_2_9_355_2","first-page":"131","volume-title":"Methods and principles in medicinal chemistry","author":"Wolber G","year":"2006"},{"key":"e_1_2_9_356_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci049638a"},{"key":"e_1_2_9_357_2","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.200430929"},{"key":"e_1_2_9_358_2","volume-title":"Pipeline Pilot"},{"key":"e_1_2_9_359_2","volume-title":"Discovery Studio"},{"key":"e_1_2_9_360_2","volume-title":"Inte:Ligand Pharmacophore Database"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.20176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.20176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.20176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:57:56Z","timestamp":1700546276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.20176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,13]]},"references-count":359,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1002\/med.20176"],"URL":"https:\/\/doi.org\/10.1002\/med.20176","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,13]]}}}