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First, the classical definition includes variants derived from TEM\u20101, TEM\u20102, or SHV\u20101; K1 (KOXY) of\n                    <jats:italic>Klebsiella oxytoca<\/jats:italic>\n                    . Second, the broadened definition has stretched the classical definition of ESBL to include: (1) \u03b2\u2010lactamases (CTX\u2010M\u2010ESBLs, GES\u2010ESBLs, and VEB\u2010ESBLs), with spectra similar to those of TEM and SHV variants (designated as TEM\u2010 and SHV\u2010ESBLs, respectively) but derived from other sources; (2) TEM and SHV variants with borderline ESBL activity; e.g., TEM\u201012; and (3) various \u03b2\u2010lactamases conferring wider resistance than their parent types but not meeting the definition for group 2be; e.g., OXA\u2010types (OXA\u2010ESBLs) and mutant AmpC\u2010types (AmpC\u2010ESBLs), with increased activity against oxyimino\u2010cephalosporins and with resistance to clavulanic acid. Third, the all\u2010inclusive definition includes: (1) ESBL\n                    <jats:sub>A<\/jats:sub>\n                    (named for class A ESBLs); (2) ESBL\n                    <jats:sub>M<\/jats:sub>\n                    (miscellaneous ESBLs), which has been subdivided into ESBL\n                    <jats:sub>M\u2010C<\/jats:sub>\n                    (class C; plasmid\u2010mediated AmpC) and ESBL\n                    <jats:sub>M\u2010D<\/jats:sub>\n                    (class D); and (3) ESBL\n                    <jats:sub>CARBA<\/jats:sub>\n                    (ESBLs with hydrolytic activity against carbapenems), which has been subdivided into ESBL\n                    <jats:sub>CARBA\u2010A<\/jats:sub>\n                    (class A carbapenemases), ESBL\n                    <jats:sub>CARBA\u2010B<\/jats:sub>\n                    (class B carbapenemases), and ESBL\n                    <jats:sub>CARBA\u2010D<\/jats:sub>\n                    (class D carbapenemases). The consensus view about the ESBL definition is that the classical ESBL definition must be expanded to class A non\u2010TEM\u2010 and non\u2010SHV\u2010ESBLs (CTX\u2010M\u2010, GES\u2010, VEB\u2010ESBLs, etc.). However, these three definitions evoke rational debate on the question \u201cWhich would be included in the category of ESBLs among AmpC\u2010ESBLs, OXA\u2010ESBLs, and\/or carbapenemases?\u201d Therefore, there is a great need for consensus in the precise definition of ESBL.\u2003\u2003\u00a9 2010 Wiley Periodicals, Inc. Med Res Rev 32:216\u2010232, 2012\n                  <\/jats:p>","DOI":"10.1002\/med.20210","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T13:28:37Z","timestamp":1277299717000},"page":"216-232","source":"Crossref","is-referenced-by-count":63,"title":["New definitions of extended\u2010spectrum \u03b2\u2010lactamase conferring worldwide emerging antibiotic resistance"],"prefix":"10.1002","volume":"32","author":[{"given":"Jung Hun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Kwon","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang","family":"Hee 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