{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:54:01Z","timestamp":1791154441825,"version":"4.1.0"},"reference-count":152,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T00:00:00Z","timestamp":1283472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been long recognized that skeleton represents one of the most favored metastatic sites for common cancers like breast and prostate. During the last decade the molecular mechanisms that are responsible for the development of bone metastasis have been gradually illuminated. It appears that the bone microenvironment has a pivotal role in this process. Metastatic tumor cells interact with bone triggering a cascade of molecular events that produce osteolytic and\/or osteoblastic phenomena. In this review, we summarize and discuss the most significant factors and signaling pathways implicated in bone colonization. Moreover, based on the recent literature and data, we foresee the need for designing novel agents that will efficiently disrupt these interactions among cancer cells and bone microenvironment, bringing hope for more effective treatments. \u00a9 2010 Wiley Periodicals, Inc. Med Res Rev, 32, No. 3, 611\u2013636, 2012<\/jats:p>","DOI":"10.1002\/med.20224","type":"journal-article","created":{"date-parts":[[2010,9,5]],"date-time":"2010-09-05T06:50:08Z","timestamp":1283669408000},"page":"611-636","source":"Crossref","is-referenced-by-count":59,"title":["Bone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions"],"prefix":"10.1002","volume":"32","author":[{"given":"Dionysios J.","family":"Papachristou","sequence":"first","affiliation":[{"name":"Department of Anatomy\u2013Histology\u2013Embryology University of Patras School of Medicine  26500 Patras Greece"},{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pennsylvania 15232 Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimia K.","family":"Basdra","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry Medical School, University of Athens  11527 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios G.","family":"Papavassiliou","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry Medical School, University of Athens  11527 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1987.13"},{"key":"e_1_2_8_3_1","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast. 1889","volume":"8","author":"Paget S","year":"1989","journal-title":"Cancer Metastasis Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194007000-00016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54735-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.1.25"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2008.07.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.4.8070"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9032-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.19.8581-8591.2005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6610"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.03.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.9.8356"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.07.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.12.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.9.1583"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.9.1575"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080627"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc867"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030831"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80127-3"},{"key":"e_1_2_8_24_1","first-page":"3059","article-title":"Localization of parathyroid hormone\u2010related protein in breast cancer metastases: Increased incidence in bone compared with other sites","volume":"51","author":"Powell GJ","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2814"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3523"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00162-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3353"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.11.6433"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.05.044"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11685"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-148"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04524"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80165-X"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9019-x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065016"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3958"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041109"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1844"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00132-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2309"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2701"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.4.309"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc704"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069825"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05238.x"},{"key":"e_1_2_8_47_1","first-page":"5830","article-title":"Overexpression of hypoxia\u2010inducible factor 1alpha in common human cancers and their metastases","volume":"59","author":"Zhong H","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2355"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006896"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03398"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.016"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01049-8"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.028"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(01)90233-7"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90491-5"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.01.022"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/379557a0"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(93)90057-N"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240530211"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0407"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(98)00094-0"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1261"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1830978100"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11129"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.10.005"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023099415940"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10662"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.05.002"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6853"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503111200"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.08106"},{"key":"e_1_2_8_72_1","first-page":"2372","article-title":"Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo","volume":"54","author":"Achbarou A","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65919-6"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1420407"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.018"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200103)23:3<207::AID-BIES1029>3.0.CO;2-0"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32816e06f9"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.017"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0346"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02546"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20735"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20518"},{"key":"e_1_2_8_83_1","first-page":"2615","article-title":"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue","volume":"54","author":"Huguet EL","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_8_84_1","first-page":"215","article-title":"Wnt5a cloning, expression, and up\u2010regulation in human primary breast cancers","volume":"1","author":"Lejeune S","year":"1995","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530291100"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.08.014"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063994"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1610"},{"key":"e_1_2_8_89_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1158\/1078-0432.1154.11.3","article-title":"Prevalence of CD44+\/CD24\u2212\n                  \/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis","volume":"11","author":"Abraham BK","year":"2005","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0524-9"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.43"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.16.3111"},{"key":"e_1_2_8_93_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3233\/BD-2007-26108","article-title":"Tumor dormancy and cancer stem cells: Implications for the biology and treatment of breast cancer metastasis","volume":"26","author":"Allan AL","year":"2007","journal-title":"Breast Dis"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2279"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1417"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0606-610"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/415530a"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22320"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1670"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.21.9802"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090664"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0843"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68891-0"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-90004-14"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000175582.01446.6f"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115539"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0551"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.01.009"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.19.1458"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh141"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.3816\/CGC.2007.n.022"},{"key":"e_1_2_8_112_1","first-page":"CD006250","article-title":"Bisphosphonates for advanced prostate cancer","volume":"4","author":"Yuen KK","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn240"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk054"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.09.012"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1933"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8604"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090810"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809003"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.048"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.01.078"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.08.130"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5279.1236"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.9.1396"},{"key":"e_1_2_8_125_1","first-page":"69","article-title":"Breast cancer cells express cathepsins B and L but not cathepsins K or H","volume":"17","author":"Ishibashi O","year":"1999","journal-title":"Cancer Biochem Biophys"},{"key":"e_1_2_8_126_1","first-page":"5386","article-title":"The osteoclast\u2010associated protease cathepsin K is expressed in human breast carcinoma","volume":"57","author":"Littlewood\u2010Evans AJ","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.60"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091035"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32832cbc2a"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1366"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0009"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208079"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.001"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn291"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603444"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2332"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116032"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.21.2835"},{"key":"e_1_2_8_139_1","first-page":"5028","article-title":"C\u2010SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis","volume":"63","author":"Myoui A","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.05.017"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9463-x"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.102004"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0929"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22996"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23864"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.11.002"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118947"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9033-z"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.09.138"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711263105"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413274200"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081206"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4499"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.20224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.20224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T16:09:25Z","timestamp":1697472565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.20224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,3]]},"references-count":152,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/med.20224"],"URL":"https:\/\/doi.org\/10.1002\/med.20224","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,3]]}}}