{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:22:14Z","timestamp":1789543334778,"version":"build-2803163510"},"reference-count":176,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human relaxin\u20102 (hereafter simply defined as \u201crelaxin\u201d) is a 6\u2010kDa peptidic hormone best known for the physiological role played during pregnancy in the growth and differentiation of the reproductive tract and in the renal and systemic hemodynamic changes. This factor can also be involved in the pathophysiology of arterial hypertension and heart failure, in the molecular pathways of fibrosis and cancer, and in angiogenesis and bone remodeling. It belongs to the relaxin peptide family, whose members comprehensively exert numerous effects through interaction with different types of receptors, classified as relaxin family peptide (RXFP) receptors (RXFP1, RXFP2, RXFP3, RXFP4). Research looks toward the in\u2010depth examination and complete understanding of relaxin in its various pleiotropic actions. The intent is to evaluate the likelihood of employing this substance for therapeutic purposes, for instance in diseases where a deficit could be part of the underlying pathophysiological mechanisms, also avoiding any adverse effect. Relaxin is already being considered as a promising drug, especially in acute heart failure. A careful study of the different RXFPs and their receptors and the comprehension of all biological activities of these hormones will probably provide new drugs with a potential wide range of therapeutic applications in the near future.<\/jats:p>","DOI":"10.1002\/med.21277","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T15:02:45Z","timestamp":1360594965000},"page":"77-105","source":"Crossref","is-referenced-by-count":45,"title":["Relaxin: New Pathophysiological Aspects and Pharmacological Perspectives for an Old Protein"],"prefix":"10.1002","volume":"34","author":[{"given":"Valeria","family":"Cernaro","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Messina  Via Consolare Valeria 1, 98100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lacquaniti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Messina  Via Consolare Valeria 1, 98100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Lupica","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Messina  Via Consolare Valeria 1, 98100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Buemi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Messina  Via Consolare Valeria 1, 98100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Trimboli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Messina  Via Consolare Valeria 1, 98100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Giorgianni","sequence":"additional","affiliation":[{"name":"Clinical Experimental Department of Medicine and Pharmacology Section of Endocrinology, University of Messina  Via Consolare Valeria, 1, 98100 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Bolignano","sequence":"additional","affiliation":[{"name":"CNR\u2010IBIM Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria  Via Vallone Petrara c\/o Ospedali Rivniti, 89100 Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Buemi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Messina  Via Consolare Valeria 1, 98100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.282194"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03829.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.03.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.02.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065654"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200398200"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2011.05.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi201093m"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.05.025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0119"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.5.5147"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704879"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199907)29:07<2241::AID-IMMU2241>3.0.CO;2-E"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/325813a0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1320149"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)39014-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61573-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-11-200006060-00004"},{"issue":"13","key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1096\/fj.03-1120fje","article-title":"Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist","volume":"18","author":"Dschietzig T","year":"2004","journal-title":"FASEB J"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.010322"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.039859"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0201"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0503"},{"issue":"4","key":"e_1_2_8_25_1","first-page":"528","article-title":"Histological effects of estradiol, progesterone, and relaxin on the symphysis pubis of the guinea pig","volume":"96","author":"Talmage RV","year":"1946","journal-title":"Anat Rec"},{"issue":"2","key":"e_1_2_8_26_1","first-page":"233","article-title":"Changes induced in the connective tissue of the pubic symphysis of the guinea pig with estrogen and relaxin","volume":"50","author":"Perl E","year":"1950","journal-title":"Arch Pathol (Chic)"},{"issue":"4","key":"e_1_2_8_27_1","first-page":"571","article-title":"The role of estrogen in the estrogen\u2010relaxin relationship in relaxation of the symphysis pubis of the guinea pig","volume":"99","author":"Talmage RV","year":"1947","journal-title":"Anat Rec"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-78-18956"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0080336"},{"issue":"3","key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/ajplegacy.1953.172.3.547","article-title":"In vitro inhibition of spontaneous contractions of the rat uterus by relaxin\u2010containing extracts of sow ovaries","volume":"172","author":"Sawyer WH","year":"1953","journal-title":"Am J Physiol"},{"issue":"2","key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0002-9378(56)90110-7","article-title":"Dilatation of the uterine cervix of the sow following treatment with relaxin","volume":"72","author":"Zarrow MX","year":"1956","journal-title":"Am J Obstet Gynecol"},{"issue":"19","key":"e_1_2_8_32_1","first-page":"678","article-title":"Relaxin and its effect on uterine motility","volume":"57","author":"Posse N","year":"1957","journal-title":"Nord Med"},{"issue":"5","key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0002-9378(56)90728-1","article-title":"Relaxin, the third ovarian hormone: Its experimental use in women","volume":"71","author":"Eichner E","year":"1956","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"e_1_2_8_34_1","first-page":"166","article-title":"The purification of relaxin","volume":"29","author":"Frieden EH","year":"1950","journal-title":"Arch Biochem"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-66-16132"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0690693"},{"issue":"3","key":"e_1_2_8_37_1","first-page":"117","article-title":"The effect of relaxin and ubiquitin on sperm motility","volume":"115","author":"Fuchs U","year":"1993","journal-title":"Zentralbl Gynakol"},{"key":"e_1_2_8_38_1","first-page":"291","article-title":"Effects of relaxin on wound healing","volume":"123","author":"Beiler JM","year":"1960","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331976201300904"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1960.00270160105013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0580043"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1092750"},{"issue":"12","key":"e_1_2_8_43_1","first-page":"715","article-title":"Uterine collagens. General review","volume":"86","author":"Borel JP","year":"1991","journal-title":"Rev Fr Gynecol Obstet"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90251-6"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-190-42857"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.6.1240"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90665-P"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb16377.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.143R005"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0120351"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920801)70:3<639::AID-CNCR2820700316>3.0.CO;2-V"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.10.002"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2006.10.008"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2010.02.022"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03829.x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.10.003"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2741\/2244"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1612"},{"key":"e_1_2_8_59_1","first-page":"H1911","article-title":"Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats","volume":"263","author":"Gilson GJ","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5630"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.129"},{"issue":"5","key":"e_1_2_8_62_1","first-page":"F777","article-title":"Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy","volume":"273","author":"Chapman AB","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-6-1771"},{"key":"e_1_2_8_64_1","first-page":"19","article-title":"Trends in serum relaxin concentration among elite collegiate female athletes","volume":"3","author":"Dragoo JL","year":"2011","journal-title":"Int J Womens Health"},{"issue":"2","key":"e_1_2_8_65_1","first-page":"167","article-title":"Relaxin in normal and pathogenic pregnancies","volume":"59","author":"Szlachter BN","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.07.020"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00239.2012"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00360.2010"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-008-0070-9"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000135975.90889.60"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03838.x"},{"issue":"4","key":"e_1_2_8_72_1","first-page":"269","article-title":"Expression of relaxin receptor in placental tissues of normal pregnancy and pre\u2010eclampsia","volume":"43","author":"Wang YQ","year":"2008","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP75226"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03826.x"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602728200"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802464463"},{"issue":"5","key":"e_1_2_8_77_1","first-page":"663","article-title":"Preeclampsia and cardiovascular risk: General characteristics, counseling and follow\u2010up","volume":"21","author":"Buemi M","year":"2008","journal-title":"J Nephrol"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-190-42857"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1126"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0070com"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/08037050902864086"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000051884.27117.7E"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr618"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00845.2010"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-74672-2_6"},{"issue":"7","key":"e_1_2_8_86_1","first-page":"455","article-title":"Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy","volume":"57","author":"Chaykovska L","year":"2011","journal-title":"Clin Lab"},{"issue":"5","key":"e_1_2_8_87_1","first-page":"352","article-title":"Suppressing myocardial fibrosis to promote myocardial regeneration as a therapeutic strategy for chronic cardiovascular diseases","volume":"41","author":"Mi S","year":"2010","journal-title":"Sheng Li Ke Xue Jin Zhan"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.164392"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000171930.00697.2f"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60622-X"},{"issue":"12","key":"e_1_2_8_91_1","first-page":"61855\u20108","article-title":"Serelaxin, recombinant human relaxin\u20102, for treatment of acute heart failure (RELAX\u2010AHF): A randomised, placebo\u2010controlled trial","volume":"0140","author":"Teerlink JR","year":"2012","journal-title":"Lancet"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.08.011"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.198"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00663-6"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128598.72920.B5"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00663-6"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0209"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00628.x"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616665"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12365206"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119099"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059003876.x"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00710-5"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00403-9"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-74672-2_7"},{"issue":"18","key":"e_1_2_8_106_1","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1016\/S0021-9258(18)87000-4","article-title":"modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts","volume":"265","author":"Unemori EN","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200115090-00005"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200011000-00011"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102050-00006"},{"issue":"12","key":"e_1_2_8_110_1","first-page":"1312","article-title":"Studies on the fibroblast proliferation and transdifferentiation for myofibroblast from skin lesion of the patients with systemic sclerosis repressed by H2 Relaxin","volume":"27","author":"Liu T","year":"2011","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.577"},{"issue":"1","key":"e_1_2_8_112_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1096\/fj.02-0449fje","article-title":"Relaxin deficiency in mice is associated with an age\u2010related progression of pulmonary fibrosis","volume":"17","author":"Samuel CS","year":"2003","journal-title":"FASEB J"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(02)00025-X"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03795.x"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1159\/000066302"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0286"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-120857"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32831b7096"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110086"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi1013968"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03823.x"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.170977"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108315299"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1350543"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000133591.47776.bd"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945009789577981"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788453194"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091121"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2000.00361.x"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-346007"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.165027"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701193290"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.10.007"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029733"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.03.684"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000079784.81186.B9"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2009.01385.x"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0307"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1177\/37.8.2666509"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2492"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03793.x"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21148"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0073"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945007779315650"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/8.9.789"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6847com"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-009-0454-1"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.256"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1370505"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5630"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021422"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.139.5.2322"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.11.5082"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-8194.2004.01184.x"},{"issue":"8","key":"e_1_2_8_155_1","first-page":"27","article-title":"Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy","volume":"59","author":"Brunton PJ","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00509.2004"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308996200"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03796.x"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.066"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03980.x"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2010.02.020"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1532"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07931.x"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030792"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.83"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.10.009"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr567"},{"issue":"3","key":"e_1_2_8_168_1","first-page":"328","article-title":"A randomized, double blind, placebo\u2010controlled trial of the safety of vaginal recombinant human relaxin for cervical ripening","volume":"82","author":"Bell RJ","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb12019.x"},{"issue":"2","key":"e_1_2_8_170_1","first-page":"302","article-title":"Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis","volume":"25","author":"Seibold JR","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-11-200006060-00004"},{"key":"e_1_2_8_172_1","unstructured":"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00333307?term=relaxin&rank=5"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03819.x"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03794.x"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24380"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.01.008"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2011.07.024"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.21277","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:10:34Z","timestamp":1696396234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,11]]},"references-count":176,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/med.21277"],"URL":"https:\/\/doi.org\/10.1002\/med.21277","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,11]]}}}