{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:36:28Z","timestamp":1791747388402,"version":"4.3.4"},"reference-count":161,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Griffith Laboratories Canada; Canada Research Chair in Bioorganic and Medicinal Chemistry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The emergence of multidrug\u2010resistant bacteria has placed a strain on health care systems and highlighted the need for new classes of antibiotics. Bacterial lipopeptides are secondary metabolites, generally produced by nonribosomal peptide synthetases that often exhibit broad\u2010spectrum antimicrobial activity. Only two new structural types of antibiotics have entered the market in the last 40 years, linezolid and the bacterial lipopeptide daptomycin. A wide variety of bacteria produce lipopeptides, however\n                    <jats:italic>Bacillus<\/jats:italic>\n                    and\n                    <jats:italic>Paenibacillus<\/jats:italic>\n                    spp. in particular have yielded several potent antimicrobial lipopeptides. Many of the lipopeptides produced by these bacteria have been known for decades and represent a potential gold mine of antibiotic candidates. This list includes the polymyxins, octapeptins, polypeptins, iturins, surfactins, fengycins, fusaricidins, and tridecaptins, as well as some novel examples, including the kurstakins. These lipopeptides have a wide variety of activities, ranging from antibacterial and antifungal, to anticancer and antiviral. This review presents a reasonably comprehensive list of each class of lipopeptide and their known homologues. Emphasis has been placed on their antimicrobial activities, as well other potential applications for this interesting class of substances.\n                  <\/jats:p>","DOI":"10.1002\/med.21321","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:24:51Z","timestamp":1401236691000},"page":"4-31","source":"Crossref","is-referenced-by-count":434,"title":["Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates"],"prefix":"10.1002","volume":"36","author":[{"given":"Stephen A.","family":"Cochrane","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Alberta  Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Vederas","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817886"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.293.5536.1786"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600350"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60401-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001104"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"258","article-title":"Lipopeptides as anti\u2010infectives: A practical perspective","volume":"4","author":"Pirri G","year":"2009","journal-title":"Cent Eur J Biol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.58.030603.123615"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.38.1610"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"43","article-title":"Polymyxin: A new chemotherapeutic agent","volume":"81","author":"Stansly PG","year":"1947","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900999h"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.10.033"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300496"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3995"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02587-12"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1949.tb27318.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00119-11"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)92299-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01901128"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.54.595"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212364200"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.26.444"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.26.449"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.26.457"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.28.379"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb43286.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)97597-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.1339"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.516"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.521"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.1241"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.36.634"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.6.665"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.32.511"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05580-11"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.33.186"},{"issue":"2","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0021-9258(18)56279-7","article-title":"Polypeptin, an antibiotic from a member of the Bacillus circulans group. 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