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Among the diseases that affect skeletal muscle are myopathy\u2010associated fibrosis, insulin resistance, and muscle atrophy. A common factor in these pathologies is the participation of the renin\u2010angiotensin system (RAS). This system can be functionally separated into the classical and nonclassical RAS axis. The main components of the classical RAS pathway are angiotensin\u2010converting enzyme (ACE), angiotensin II (Ang\u2010II), and Ang\u2010II receptors (AT receptors), whereas the nonclassical axis is composed of ACE2, angiotensin 1\u20137 [Ang (1\u20137)], and the Mas receptor. Hyperactivity of the classical axis in skeletal muscle has been associated with insulin resistance, atrophy, and fibrosis. In contrast, current evidence supports the action of the nonclassical RAS as a counter\u2010regulator axis of the classical RAS pathway in skeletal muscle. In this review, we describe the mechanisms involved in the pathological effects of the classical RAS, advances in the use of pharmacological molecules to inhibit this axis, and the beneficial effects of stimulation of the nonclassical RAS pathway on insulin resistance, atrophy, and fibrosis in skeletal muscle.<\/jats:p>","DOI":"10.1002\/med.21343","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T08:59:35Z","timestamp":1426064375000},"page":"437-463","source":"Crossref","is-referenced-by-count":133,"title":["Renin\u2010Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle"],"prefix":"10.1002","volume":"35","author":[{"given":"Claudio","family":"Cabello\u2010Verrugio","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda y Fisiopatolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Biol\u00f3gicas &amp; Facultad de Medicina Universidad Andres Bello Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Morales","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda y Fisiopatolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Biol\u00f3gicas &amp; 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