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Perhaps the only facet of noscapine's profile more astounding than its versatility is its virtual lack of side effects and addictive properties, which distinguishes it from other denizens of <jats:italic>Papaver somniferum<\/jats:italic>. This review intimately chronicles the rich intellectual and pharmacological history behind the noscapine family of compounds, the length of whose arms was revealed over decades of patient scholarship and experimentation. We discuss the intriguing story of this family of nontoxic alkaloids, from noscapine's purification from opium at the turn of the 19th century in Paris to the recent torrent of rationally designed analogs with tremendous anticancer potential. In between, noscapine's unique pharmacology; impact on cellular signaling pathways, the mitotic spindle, and centrosome clustering; use as an antimalarial drug and cough suppressant; and exceptional potential as a treatment for polycystic ovarian syndrome, strokes, and diverse malignancies are catalogued. Seminal experiments involving some of its more promising analogs, such as amino\u2010noscapine, 9\u2010nitronoscapine, 9\u2010bromonoscapine, and reduced bromonoscapine, are also detailed. Finally, the bright future of these oftentimes even more exceptional derivatives is described, rounding out a portrait of a truly remarkable family of compounds.<\/jats:p>","DOI":"10.1002\/med.21357","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T20:50:19Z","timestamp":1436907019000},"page":"1072-1096","source":"Crossref","is-referenced-by-count":123,"title":["The Noscapine Chronicle: A Pharmaco\u2010Historic Biography of the Opiate Alkaloid Family and its Clinical Applications"],"prefix":"10.1002","volume":"35","author":[{"given":"Padmashree C. G.","family":"Rida","sequence":"first","affiliation":[{"name":"Novazoi Theranostics, Inc  Plano Texas 75025 USA"},{"name":"Department of Biology Georgia State University  Atlanta GA 30303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon","family":"LiVecche","sequence":"additional","affiliation":[{"name":"Department of Biology Georgia State University  Atlanta GA 30303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ogden","sequence":"additional","affiliation":[{"name":"Department of Biology Georgia State University  Atlanta GA 30303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Aneja","sequence":"additional","affiliation":[{"name":"Department of Biology Georgia State University  Atlanta GA 30303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_16_2_1","article-title":"Opium for the Masses: Harvesting Nature's Best Pain Medication","author":"Hogshire J.","journal-title":"Feral House, Port Townsend, WA; 2009"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/npre.2013.11.8.376"},{"key":"e_1_2_16_4_1","unstructured":"InstituteMR.Noscapine: A Safe Cough Suppressant with Newly Discovered Effects in Treating Cancer and Stroke.2007.http:\/\/www.pcref.org\/MedInsight%20\u2010%20PCREF%20Noscapine%20Review.pdf."},{"issue":"1","key":"e_1_2_16_5_1","first-page":"139","article-title":"Pierre\u2010Jean Robiquet","volume":"24","author":"Wisniak J","year":"2013","journal-title":"Educ Quim"},{"issue":"1","key":"e_1_2_16_6_1","first-page":"5","article-title":"The action of opium and narcotine in malaria","volume":"18","author":"Chopra RN","year":"1930","journal-title":"Indian J Med Res"},{"key":"e_1_2_16_7_1","unstructured":"National Center for Biotechnology Information. 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