{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:06:40Z","timestamp":1780376800436,"version":"3.54.1"},"reference-count":290,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0A7514N, G089213N, G029112N, 12D8516N, 1508015N"],"award-info":[{"award-number":["G0A7514N, G089213N, G029112N, 12D8516N, 1508015N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds","doi-asserted-by":"publisher","award":["BOF15DOC04"],"award-info":[{"award-number":["BOF15DOC04"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell\u2010based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke. These cells showed great preclinical promise despite the fact that the precise mechanism of action and the optimal administration route are unknown. To gain dynamic insights into the underlying repair processes after stem cell engraftment, noninvasive imaging modalities were developed to provide detailed spatial and functional information on the donor cell fate and host microenvironment. This review will focus on MSCs and iPSCs as types of widely used stem cell sources in current (bio)medical research and compare their efficacy and potential to ameliorate the disease outcome in animal stroke models. In addition, novel noninvasive imaging strategies allowing temporospatial in vivo tracking of transplanted cells and coinciding evaluation of neuronal repair following stroke will be discussed.<\/jats:p>","DOI":"10.1002\/med.21400","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T10:57:27Z","timestamp":1469098647000},"page":"1080-1126","source":"Crossref","is-referenced-by-count":66,"title":["Stem Cell\u2010Based Therapies for Ischemic Stroke: Preclinical Results and the Potential of Imaging\u2010Assisted Evaluation of Donor Cell Fate and Mechanisms of Brain Regeneration"],"prefix":"10.1002","volume":"36","author":[{"given":"Pascal","family":"Gervois","sequence":"first","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Wolfs","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ratajczak","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00f6rg","family":"Dillen","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Vangansewinkel","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hilkens","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Bronckaers","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Lambrichts","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Struys","sequence":"additional","affiliation":[{"name":"Morphology Research Group, Biomedical Research Institute, Hasselt University Campus Diepenbeek Bioville Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"NicholsM TownsendN ScarboroughP LealJ Luengo\u2010FernandezR GrayA RaynerM.European Cardiovascular Disease Statistics 2012: European Heart Network Brussels and European Society of Cardiology Sophia Antipolis;2012."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000441139.02102.80"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200710000-00005"},{"key":"e_1_2_9_5_1","first-page":"27","volume-title":"Neurological Disorders: Public Health Challenges","author":"Dua T","year":"2006"},{"key":"e_1_2_9_6_1","unstructured":"United Nations Department of Economic and Social Affairs. Magnitude and Speed of Poplation Ageing. World Population Ageing 1950\u20102050. New York NY: Population Division DESA United Nations;2002. p 11\u201313."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182762397"},{"issue":"9913","key":"e_1_2_9_8_1","first-page":"245","article-title":"Global burden of diseases I, risk factors S, the GBDSEG","volume":"383","author":"Feigin VL","year":"2014","journal-title":"Global and regional burden of stroke during 1990\u20102010: Findings from the Global Burden of Disease Study 2010. Lancet"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04960"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599654"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9575-3"},{"issue":"10","key":"e_1_2_9_12_1","first-page":"1407","article-title":"Stroke\u20101989: Recommendations on stroke prevention, diagnosis, and therapy","volume":"20","author":"Goldstein M","year":"1989","journal-title":"Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60694-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00386-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01401-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000217418.29609.22"},{"issue":"17","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000074790","article-title":"The ischemic penumbra: Identification, evolution and treatment concepts","volume":"1","author":"Fisher M","year":"2004","journal-title":"Cerebrovasc Dis"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.09.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70545-2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112134"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0183-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571935"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.203"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000144051.32131.09"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510321"},{"issue":"9","key":"e_1_2_9_26_1","article-title":"Organised inpatient (stroke unit) care for stroke","author":"Langhorne P","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"24","key":"e_1_2_9_27_1","first-page":"1581","article-title":"The National Institute of Neurological Disorders and Stroke rt\u2010PA Stroke Study Group","volume":"333","year":"1995","journal-title":"Tissue plasminogen activator for acute ischemic stroke. N Engl J Med"},{"issue":"13","key":"e_1_2_9_28_1","first-page":"1017","article-title":"Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke","volume":"274","author":"Hacke W","year":"1995","journal-title":"The European Cooperative Acute Stroke Study (ECASS). JAMA"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04011-7"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70036-4"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206546.76860.6b"},{"key":"e_1_2_9_33_1","first-page":"778","volume-title":"Adams and Victor's Principles of Neurology","author":"Ropper AH","year":"2014"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15692-4"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1286"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00910.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60584-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002713"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000171066.25248.1d"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12652"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251441.89665.bc"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015178"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12607"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12294"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aa5241"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.598763"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(99)90018-7"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22038"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6503"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6126"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80956-3"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1553558"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.12.006"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102194"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm837"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt278"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1104"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2011-0039"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt159"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5165-05.2006"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420622"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.454"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338654"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.096"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0117"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.3.472"},{"key":"e_1_2_9_69_1","first-page":"34","article-title":"Animal models of ischemic stroke","volume":"4","author":"Bacigaluppi M","year":"2010","journal-title":"Part two: Modeling cerebral ischemia. Open Neurol J"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.4.738"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7853"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.603621"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.04.033"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109305"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-012-9798-2"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-1062"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0281"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005078"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.670299"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.71"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-011-9336-x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.001"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1970"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1676-05.2005"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)90203-8"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.011"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.138"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.02.013"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.03.008"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306562110"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000173794.72151.88"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.55"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.198"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.07.018"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/2162-3619-2-9"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-4-17"},{"issue":"4","key":"e_1_2_9_100_1","first-page":"393","article-title":"The development of fibroblast colonies in monolayer cultures of guinea\u2010pig bone marrow and spleen cells","volume":"3","author":"Friedenstein AJ","year":"1970","journal-title":"Cell Tissue Kinet"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240309797"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0330"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01986.x"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937635100"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20469"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101442"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0149"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1630-x"},{"issue":"4","key":"e_1_2_9_111_1","first-page":"315","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells","volume":"8","author":"Dominici M","year":"2006","journal-title":"The International Society for Cellular Therapy position statement. Cytotherapy"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240701358445"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321400"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0197"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt227"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2009.03.017"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-30"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078514"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.10.029"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0396"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.02.006"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03314.x"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-243980"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.12.001"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071104"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0686"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-2-13"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127302"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.677328"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0078"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318195742e"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-014-5157-9"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-63"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134920"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009854"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22279"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl207"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0011"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.014"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2010.549122"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657251"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.01.001"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0078-1"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.502047"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.09.018"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368909X474230"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600311"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.481218"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X658674"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00130"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.08.092"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0406-3"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.165"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.563015"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12062"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1757"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0131"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910012107"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0151"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801677105"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.12.001"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2249"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt224"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0369-7"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.07.008"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9549-5"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0922"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X653228"},{"issue":"4","key":"e_1_2_9_171_1","first-page":"547","article-title":"Human induced pluripotent stem cells improve recovery in stroke\u2010injured aged rats","volume":"32","author":"Tatarishvili J","year":"2014","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.09.008"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0184"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201401483"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.11.2707"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.87"},{"issue":"2","key":"e_1_2_9_177_1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0022-3565(25)10545-4","article-title":"Strain\u2010dependent drug effects in rat middle cerebral artery occlusion model of stroke","volume":"274","author":"Sauter A","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-1-8"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720207781387213"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.81"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.100"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.584"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0452"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0463"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1047403"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2293021215"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657774"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242435499"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.3666"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3107"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X637416"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652309788488596"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.3677"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2007.05.009"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000163546.27639.AA"},{"issue":"8","key":"e_1_2_9_196_1","first-page":"1295","article-title":"Tissue distribution of 18F\u2010FDG\u2010labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction","volume":"47","author":"Kang WJ","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1753-9"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.03.062"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.108316"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318156b980"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.777102"},{"issue":"1","key":"e_1_2_9_202_1","first-page":"61","article-title":"In vivo visualization of 111In labeled CD133+ peripheral blood stem cells after intracoronary administration in patients with chronic ischemic heart disease","volume":"51","author":"Caveliers V","year":"2007","journal-title":"Q J Nucl Med Mol Imaging"},{"issue":"3","key":"e_1_2_9_203_1","first-page":"512","article-title":"111In\u2010labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model","volume":"45","author":"Brenner W","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0275-3"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.509"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.2.725"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094833"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000120308.21946.5D"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.05.014"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.4.111901.093336"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1037"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2869"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319000111"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22761"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6092-09.2010"},{"issue":"19","key":"e_1_2_9_216_1","first-page":"4333","article-title":"Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography","volume":"58","author":"Tjuvajev JG","year":"1998","journal-title":"Cancer Res"},{"issue":"3","key":"e_1_2_9_217_1","first-page":"467","article-title":"Quantitative kinetics of [124I]FIAU in cat and man","volume":"42","author":"Jacobs A","year":"2001","journal-title":"J Nucl Med"},{"issue":"8","key":"e_1_2_9_218_1","first-page":"1225","article-title":"Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: A reporter probe for imaging herpes simplex virus type\u20101 thymidine kinase reporter gene expression","volume":"42","author":"Yaghoubi S","year":"2001","journal-title":"J Nucl Med"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300877"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.079004"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652312799789235"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.665"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.087684"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC03454F"},{"issue":"2","key":"e_1_2_9_225_1","first-page":"87","article-title":"Dual\u2010modality probes for in vivo molecular imaging","volume":"8","author":"Lee S","year":"2009","journal-title":"Mol Imaging"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.085"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.104"},{"key":"e_1_2_9_228_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.575993"},{"key":"e_1_2_9_229_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.594648"},{"key":"e_1_2_9_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.05.019"},{"issue":"3","key":"e_1_2_9_231_1","first-page":"735","article-title":"Imaging neuroinflammation after brain injuries by ultrasensitive MRI and two\u2010photon laser\u2010scanning microscopy","volume":"55","author":"Scheller A","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_9_232_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018743108"},{"key":"e_1_2_9_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3495"},{"key":"e_1_2_9_234_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4249-08.2009"},{"key":"e_1_2_9_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1479"},{"key":"e_1_2_9_236_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23502"},{"key":"e_1_2_9_237_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00274"},{"key":"e_1_2_9_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.02.010"},{"key":"e_1_2_9_239_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.111112"},{"key":"e_1_2_9_240_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X656144"},{"key":"e_1_2_9_241_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.118380"},{"key":"e_1_2_9_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.149"},{"key":"e_1_2_9_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.07.001"},{"key":"e_1_2_9_244_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4147-07.2008"},{"issue":"8","key":"e_1_2_9_245_1","first-page":"1591","article-title":"Diffusion\u2010 and perfusion\u2010weighted MRI","volume":"30","author":"Neumann\u2010Haefelin T","year":"1999","journal-title":"The DWI\/PWI mismatch region in acute stroke. Stroke"},{"key":"e_1_2_9_246_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10803"},{"key":"e_1_2_9_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.69"},{"key":"e_1_2_9_248_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0029-0"},{"key":"e_1_2_9_249_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000252127.07428.9c"},{"key":"e_1_2_9_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.031"},{"key":"e_1_2_9_251_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400515"},{"key":"e_1_2_9_252_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-992-5_7"},{"key":"e_1_2_9_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.001"},{"key":"e_1_2_9_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.124"},{"key":"e_1_2_9_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400308"},{"key":"e_1_2_9_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20453"},{"key":"e_1_2_9_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.218"},{"key":"e_1_2_9_258_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20501"},{"key":"e_1_2_9_259_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr063"},{"key":"e_1_2_9_260_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.430"},{"key":"e_1_2_9_261_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.238"},{"key":"e_1_2_9_262_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0253"},{"key":"e_1_2_9_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.03.017"},{"key":"e_1_2_9_264_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000278"},{"key":"e_1_2_9_265_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10720"},{"key":"e_1_2_9_266_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05934"},{"key":"e_1_2_9_267_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1374"},{"key":"e_1_2_9_268_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.85.348"},{"key":"e_1_2_9_269_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.531"},{"key":"e_1_2_9_270_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008975"},{"key":"e_1_2_9_271_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1554"},{"key":"e_1_2_9_272_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3034"},{"key":"e_1_2_9_273_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409933111"},{"key":"e_1_2_9_274_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1819"},{"key":"e_1_2_9_275_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.21-3-257"},{"key":"e_1_2_9_276_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00536.x"},{"key":"e_1_2_9_277_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0362-1"},{"key":"e_1_2_9_278_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23559"},{"key":"e_1_2_9_279_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-1-2"},{"key":"e_1_2_9_280_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000821"},{"key":"e_1_2_9_281_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0178"},{"key":"e_1_2_9_282_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X684934"},{"key":"e_1_2_9_283_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22458"},{"key":"e_1_2_9_284_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007028"},{"key":"e_1_2_9_285_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00347"},{"key":"e_1_2_9_286_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/839638"},{"key":"e_1_2_9_287_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000071883.63724.A7"},{"key":"e_1_2_9_288_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300749"},{"key":"e_1_2_9_289_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000189991.23918.01"},{"key":"e_1_2_9_290_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00044"},{"key":"e_1_2_9_291_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202612666150311112550"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.21400","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.21400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T03:40:16Z","timestamp":1749008416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":290,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/med.21400"],"URL":"https:\/\/doi.org\/10.1002\/med.21400","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,21]]}}}