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Of the current treatments offering partial and temporary relief, ultraviolet (UV) light is the most effective, coordinating an intricate network of keratinocyte and melanocyte factors that control numerous cellular and molecular signaling pathways. This UV\u2010activated process is a classic example of regenerative medicine, inducing functional melanocyte stem cell populations in the hair follicle to divide, migrate, and differentiate into mature melanocytes that regenerate the epidermis through a complex process involving melanocytes and other cell lineages in the skin. Using an in\u2010depth correlative analysis of multiple experimental and clinical data sets, we generated a modern molecular research platform that can be used as a working model for further research of vitiligo repigmentation. Our analysis emphasizes the active participation of defined molecular pathways that regulate the balance between stemness and differentiation states of melanocytes and keratinocytes: p53 and its downstream effectors controlling melanogenesis; Wnt\/\u03b2\u2010catenin with proliferative, migratory, and differentiation roles in different pigmentation systems; integrins, cadherins, tetraspanins, and metalloproteinases, with promigratory effects on melanocytes; TGF\u2010\u03b2 and its effector PAX3, which control differentiation. Our long\u2010term goal is to design pharmacological compounds that can specifically activate melanocyte precursors in the hair follicle in order to obtain faster, better, and durable repigmentation.<\/jats:p>","DOI":"10.1002\/med.21426","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T10:08:35Z","timestamp":1482919715000},"page":"907-935","source":"Crossref","is-referenced-by-count":103,"title":["Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization"],"prefix":"10.1002","volume":"37","author":[{"given":"Stanca A.","family":"Birlea","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine University of Colorado Anschutz Medical Campus  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude\u2010E.","family":"Costin","sequence":"additional","affiliation":[{"name":"Institute for In Vitro Sciences, Inc. 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