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Notably, the paucity of new efficient drug molecules and the inevitable drug resistance of the malaria parasite, <jats:italic>Plasmodium falciparum<\/jats:italic>, against frontline therapeutics are the foremost struggles facing malaria eradication initiatives. According to the malaria eradication agenda, the discovery of new chemical entities that can destroy the parasite at the liver stage, the asexual blood stage, the gametocyte stage, and the insect ookinete stage of the parasite life cycle (i.e., compounds exhibiting multistage activity) are in high demand, preferably with novel and multiple modes of action. Phenotypic screening of chemical libraries against the malaria parasite is certainly a crucial step toward overcoming these crises. In the last few years, various research groups, including industrial research laboratories, have performed large\u2010scale phenotypic screenings that have identified a wealth of chemical entities active against multiple life stages of the malaria parasite. Vital scientific and technological developments have led to the discovery of multistage inhibitors of the malaria parasite; these compounds, considered highly valuable starting points for subsequent drug discovery and eradication of malaria, are reviewed.<\/jats:p>","DOI":"10.1002\/med.21486","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T06:56:48Z","timestamp":1516949808000},"page":"1511-1535","source":"Crossref","is-referenced-by-count":35,"title":["Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication"],"prefix":"10.1002","volume":"38","author":[{"family":"Poonam","sequence":"first","affiliation":[{"name":"Department of Chemistry Miranda House, University of Delhi  India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash","family":"Gupta","sequence":"additional","affiliation":[{"name":"National Institute of Malaria Research (ICMR)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Special Centre for Nanosciences Jawaharlal Nehru University  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snigdha","family":"Singh","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry Hansraj College University Enclave, University of Delhi  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Massachusetts Institute of Technology  Cambridge MA USA"},{"name":"Key Laboratory of Control of Quality and Safety for Aquatic Products Ministry of Agriculture, Chinese Academy of Fishery Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupender Singh","family":"Chhikara","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Aditi Mahavidyalaya University of Delhi  Bawana Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manmeet","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of New Mexico School of Medicine  Albuquerque NM USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-8847","authenticated-orcid":false,"given":"Brijesh","family":"Rathi","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry Hansraj College University Enclave, University of Delhi  Delhi India"},{"name":"Department of Chemistry Massachusetts Institute of Technology  Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70177-X"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.World Malaria Report 2016.Geneva: Switzerland;2016."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3138"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15535"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.11.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666170130123520"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2011.03.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-016-0027-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11901"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70032-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60484-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu491"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4573"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0544-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1403007"},{"key":"e_1_2_8_21_1","unstructured":"World Health Organization.Status report on artemisinin resistance. 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