{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:24:46Z","timestamp":1790151886066,"version":"4.0.1"},"reference-count":221,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY10101"],"award-info":[{"award-number":["EY10101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY023691"],"award-info":[{"award-number":["EY023691"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY021886"],"award-info":[{"award-number":["EY021886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["I01 BX002386"],"award-info":[{"award-number":["I01 BX002386"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, lymphangiogenesis, the process of lymphatic vessel formation from existing lymph vessels, has been demonstrated to have a significant role in diverse pathologies, including cancer metastasis, organ graft rejection, and lymphedema. Our understanding of the mechanisms of lymphangiogenesis has advanced on the heels of studies demonstrating vascular endothelial growth factor C as a central pro\u2010lymphangiogenic regulator and others identifying multiple lymphatic endothelial biomarkers. Despite these breakthroughs and a growing appreciation of the signaling events that govern the lymphangiogenic process, there are no FDA\u2010approved drugs that target lymphangiogenesis. In this review, we reflect on the lessons available from the development of antiangiogenic therapies (26 FDA\u2010approved drugs to date), review current lymphangiogenesis research including nanotechnology in therapeutic drug delivery and imaging, and discuss molecules in the lymphangiogenic pathway that are promising therapeutic targets.<\/jats:p>","DOI":"10.1002\/med.21496","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T14:38:39Z","timestamp":1520865519000},"page":"1769-1798","source":"Crossref","is-referenced-by-count":48,"title":["Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies\u2014A review"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael","family":"Yamakawa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M.","family":"Santosa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Montana","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen C.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering University of Illinois at Urbana\u2212Champaign  Urbana IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoon","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Illinois at Urbana\u2212Champaign  Urbana IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Yeon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I.","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrius","family":"Kazlauskas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"},{"name":"Department of Physiology and Biophysics, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7993-1144","authenticated-orcid":false,"given":"Jin\u2010Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri T.","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine University of Illinois at Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1945-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.045"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9406-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.12.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/362841a0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-6-713"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2017.06.006"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20059"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2015.09.007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00521.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4774"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.4.789"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/6844"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65285-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3566"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.6630"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.6457"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.0982"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.7912"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.2388"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.1595"},{"issue":"1","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1186\/s12885-016-2823-y","article-title":"SAKK 24\/09: safety and tolerability of bevacizumab plus paclitaxel vs. bevacizumab plus metronomic cyclophosphamide and capecitabine as first\u2010line therapy in patients with HER2\u2010negative advanced stage breast cancer: a multicenter, randomized phase III trial","volume":"16","author":"Rochlitz C","year":"2016","journal-title":"BMC Cancer"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.09.024"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.098"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.1255"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70444-9"},{"issue":"11","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S1470-2045(14)70439-5","article-title":"Bevacizumab plus chemotherapy versus chemotherapy alone as second\u2010line treatment for patients with HER2\u2010negative locally recurrent or metastatic breast cancer after first\u2010line treatment with bevacizumab plus chemotherapy (TANIA): an open\u2010label, randomised phase 3 trial","volume":"15","author":"Minckwitz G","year":"2014","journal-title":"Lancet Oncol"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw077"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394280-7.00006-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.03.008"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1862-5"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1131152"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.10.039"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2016.08.04"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i32.4003"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/204946"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3677"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.12.011"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.01.020"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-009-9160-6"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2013.08.001"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.3.851"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.14.3312"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199209023937"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01746"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1400731"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2380"},{"issue":"1","key":"e_1_2_12_50_1","first-page":"327","article-title":"In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet\u2010derived growth factor receptors: determination of a pharmacokinetic\/pharmacodynamic relationship","volume":"9","author":"Mendel DB","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21452"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021491"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.022"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072113"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.9930"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp233"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70212"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_182_17"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.02.007"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.027"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.83"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.03.002"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2013.730522"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-3088"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0084-4"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.01.001"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02534-1"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.12.003"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3064"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9420-y"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1MR1016-434RR"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07806-4"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-1646-3_10"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71606"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010171"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217697385"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-016-9529-2"},{"key":"e_1_2_12_78_1","article-title":"Intravital imaging reveals dynamics of lymphangiogenesis and valvulogenesis","volume":"6","author":"Kang GJ","year":"2016","journal-title":"Sci Rep"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-017-9572-7"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18526"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2016.80"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc863"},{"issue":"16","key":"e_1_2_12_83_1","first-page":"4324","article-title":"Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation","volume":"60","author":"Leu AJ","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0115"},{"issue":"5","key":"e_1_2_12_85_1","first-page":"1315","article-title":"Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer","volume":"62","author":"Beasley NJ","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64255-1"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041896"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-021758"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800410"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1800"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4494"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.01.005"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.01.008"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0484-1"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-012-0576-5"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.083"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2545"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2010.486100"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200105000-00002"},{"issue":"6","key":"e_1_2_12_100_1","first-page":"834","article-title":"Effect of sorafenib in a murine high risk penetrating keratoplasty model","volume":"10","author":"Cho YK","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01638.x"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1338-9"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00320.2016"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.12.020"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-060116-022900"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/804675"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70076-7"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222695"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126908"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/84643"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2006.05.009"},{"issue":"1","key":"e_1_2_12_112_1","first-page":"10","article-title":"Lymphangiogenesis and lymphangiogenic growth factors","volume":"32","author":"Hartiala P","year":"2016","journal-title":"J Reconstr Microsurg"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-012-9297-6"},{"issue":"3","key":"e_1_2_12_114_1","first-page":"746","article-title":"FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33\u2010qter","volume":"52","author":"Aprelikova O","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.736801"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83967"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.593"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8010001"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20465"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23874"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00075"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.083"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.124"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5404"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.11.012"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2077"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.47.28316"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.215"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2001.112.re21"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.02.001"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.05.003"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600413200"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79693"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-015-9469-2"},{"issue":"2","key":"e_1_2_12_135_1","first-page":"827","article-title":"VEGFR\u20103 blocking deteriorates inflammation with impaired lymphatic function and different changes in lymphatic vessels in acute and chronic colitis","volume":"8","author":"Wang XL","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.106"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-734210"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903180"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.266"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16186"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.11.006"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4539"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0343com"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1086\/679704"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114576"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.277"},{"issue":"9","key":"e_1_2_12_147_1","first-page":"1983","article-title":"Blockade of VEGF receptor\u20103 aggravates inflammatory bowel disease and lymphatic vessel enlargement","volume":"19","author":"Jurisic G","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.4"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04759.x"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24764"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.01.001"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522037"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal4712"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71607"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73316"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5944"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20070"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20209"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1962"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21260"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190802312844"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.011"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2015.08.002"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115041"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2904"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2610-x"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64253-8"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3387"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.08200"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804543106"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034045"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050753"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v17i3.520"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2947"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/986725"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3388"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.04.024"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132661"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-13"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.06322"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/315240"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155413489311"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58709"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.272"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2459"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1548"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.05.037"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025220"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062040199"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404272101"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13234"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.26"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208324109"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-450502"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506375102"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0465"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.1.8.555"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.08.034"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32479"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131643"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0101"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.278"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317711658"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20485"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21028"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13488"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25253"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.5.3079"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24244"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605296"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2366"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03166.x"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-010-9343-y"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1521-5"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9443"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3134-3"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701122"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6719"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8393"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05454"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2013.06.022"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.243035190"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.21496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T04:17:23Z","timestamp":1694924243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":221,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/med.21496"],"URL":"https:\/\/doi.org\/10.1002\/med.21496","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]}}}