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A brief description of additional pharmacologic applications for CA IX inhibition in other diseases, such as arthritis and ischemia, is also provided.<\/jats:p>","DOI":"10.1002\/med.21497","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T23:34:44Z","timestamp":1523403284000},"page":"1799-1836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":241,"title":["Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"first","affiliation":[{"name":"Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Alterio","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2010CNR  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Fiore","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2010CNR  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"D\u2019 Ambrosio","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2010CNR  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[{"name":"Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona Maria","family":"Monti","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2010CNR  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-5431","authenticated-orcid":false,"given":"Giuseppina","family":"De Simone","sequence":"additional","affiliation":[{"name":"Istituto di Biostrutture e Bioimmagini\u2010CNR  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_11_3_1","volume-title":"Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications","author":"Supuran CT","year":"2015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314029"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90464-Z"},{"key":"e_1_2_11_6_1","first-page":"2877","article-title":"Cloning and characterization of MN, a human tumor\u2010associated protein with a domain homologous to carbonic anhydrase and a putative helix\u2010loop\u2010helix DNA binding segment","volume":"9","author":"Pastorek J","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0223"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.798648"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799034851"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793429841"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.795145"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101541x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4261"},{"key":"e_1_2_11_16_1","unstructured":"Safety Study of SLC\u20120111 in Subjects With Advanced Solid Tumours. 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