{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:16:18Z","timestamp":1785906978131,"version":"3.56.0"},"reference-count":183,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cleft lip with or without cleft palate is a congenital deformity that occurs in about 1 of 700 newborns, affecting the dentition, bone, skin, muscles and mucosa in the orofacial region. A cleft can give rise to problems with maxillofacial growth, dental development, speech, and eating, and can also cause hearing impairment. Surgical repair of the lip may lead to impaired regeneration of muscle and skin, fibrosis, and scar formation. This may result in hampered facial growth and dental development affecting oral function and lip and nose esthetics. Therefore, secondary surgery to correct the scar is often indicated. We will discuss the molecular and cellular pathways involved in facial and lip myogenesis, muscle anatomy in the normal and cleft lip, and complications following surgery. The aim of this review is to outline a novel molecular and cellular strategy to improve musculature and skin regeneration and to reduce scar formation following cleft repair. Orofacial clefting can be diagnosed in the fetus through prenatal ultrasound screening and allows planning for the harvesting of umbilical cord blood stem cells upon birth. Tissue engineering techniques using these cord blood stem cells and molecular targeting of inflammation and fibrosis during surgery may promote tissue regeneration. We expect that this novel strategy improves both muscle and skin regeneration, resulting in better function and esthetics after cleft repair.<\/jats:p>","DOI":"10.1002\/med.21594","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T08:28:04Z","timestamp":1558254484000},"page":"9-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair"],"prefix":"10.1002","volume":"40","author":[{"given":"Micha\u00ebl","family":"Schreurs","sequence":"first","affiliation":[{"name":"Department of Dentistry, Section of Orthodontics and Craniofacial Biology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Maarten","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Section of Orthodontics and Craniofacial Biology Radboud University Medical Centre Nijmegen The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henricus A.M","family":"Mutsaers","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Kuijpers\u2010Jagtman","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universitas Indonesia Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes W.","family":"Von den Hoff","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Section of Orthodontics and Craniofacial Biology Radboud University Medical Centre Nijmegen The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Ongkosuwito","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Section of Orthodontics and Craniofacial Biology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola L.","family":"Carvajal Monroy","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery, Special Dental Care and Orthodontics Erasmus University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-1559","authenticated-orcid":false,"given":"Frank A.D.T.G.","family":"Wagener","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Section of Orthodontics and Craniofacial Biology Radboud University Medical Centre Nijmegen The Netherlands"},{"name":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,18]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(06)60001-2"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182402dd1"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi214"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57187"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cxom.2014.05.001"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2013.12.003"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20117"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn186"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776389868"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.028"},{"key":"e_1_2_10_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000158745.84019.c2"},{"key":"e_1_2_10_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.10.002"},{"key":"e_1_2_10_1_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2013.00053"},{"key":"e_1_2_10_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618767106"},{"key":"e_1_2_10_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_10_1_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517723326"},{"key":"e_1_2_10_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.07.015"},{"key":"e_1_2_10_1_20_1","doi-asserted-by":"publisher","DOI":"10.1597\/03-142.1"},{"key":"e_1_2_10_1_21_1","first-page":"1","article-title":"Speech outcome in young children born with unilateral cleft lip and palate treated with one\u2010 or two\u2010stage palatal repair and the impact of early intervention","author":"Raud Westberg L","year":"2017","journal-title":"Logoped Phoniatr Vocol"},{"key":"e_1_2_10_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.59"},{"key":"e_1_2_10_1_23_1","doi-asserted-by":"publisher","DOI":"10.1597\/04-163r.1"},{"key":"e_1_2_10_1_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2016.1254644"},{"issue":"2","key":"e_1_2_10_1_25_1","first-page":"53","article-title":"How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? literature review","volume":"16","author":"Farronato G","year":"2014","journal-title":"Stomatologija"},{"key":"e_1_2_10_1_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.139246"},{"key":"e_1_2_10_1_27_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-026.1"},{"key":"e_1_2_10_1_28_1","doi-asserted-by":"publisher","DOI":"10.1078\/0940-2993-00235"},{"key":"e_1_2_10_1_29_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-178"},{"key":"e_1_2_10_1_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.002501"},{"key":"e_1_2_10_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.03.003"},{"key":"e_1_2_10_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20646"},{"key":"e_1_2_10_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31381"},{"key":"e_1_2_10_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00472.x"},{"key":"e_1_2_10_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.12.035"},{"key":"e_1_2_10_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001200207"},{"key":"e_1_2_10_1_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182a2dce4"},{"key":"e_1_2_10_1_38_1","volume-title":"Cleft Lip and Palate; Surgical, Dental, and Speech Aspects","author":"Grabb WC","year":"1971"},{"key":"e_1_2_10_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.10.005"},{"key":"e_1_2_10_1_40_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1993_030_0313_dcsoap_2.3.co_2"},{"key":"e_1_2_10_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(79)80022-3"},{"key":"e_1_2_10_1_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200011030-00004"},{"key":"e_1_2_10_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0915-6992(02)80007-3"},{"key":"e_1_2_10_1_44_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2001)038<0438:MCOTLV>2.0.CO;2"},{"key":"e_1_2_10_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.10.005"},{"key":"e_1_2_10_1_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198905000-00002"},{"key":"e_1_2_10_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800580805"},{"key":"e_1_2_10_1_48_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2018.44.1.3"},{"key":"e_1_2_10_1_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.125419"},{"key":"e_1_2_10_1_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2016.1263202"},{"key":"e_1_2_10_1_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001340"},{"key":"e_1_2_10_1_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000258518.81309.70"},{"key":"e_1_2_10_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.11.019"},{"key":"e_1_2_10_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2006.03.005"},{"key":"e_1_2_10_1_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200309000-00003"},{"key":"e_1_2_10_1_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0485"},{"key":"e_1_2_10_1_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450111009011571"},{"key":"e_1_2_10_1_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/790234"},{"key":"e_1_2_10_1_59_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962009000300007"},{"key":"e_1_2_10_1_60_1","first-page":"301","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby IA","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_10_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1427"},{"key":"e_1_2_10_1_62_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_10_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.010"},{"key":"e_1_2_10_1_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_10_1_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00081"},{"key":"e_1_2_10_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386035-4.00001-X"},{"key":"e_1_2_10_1_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322399"},{"key":"e_1_2_10_1_68_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.6.751"},{"key":"e_1_2_10_1_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12283"},{"key":"e_1_2_10_1_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/89759"},{"key":"e_1_2_10_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.11.010"},{"key":"e_1_2_10_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.09.001"},{"key":"e_1_2_10_1_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.06.020"},{"key":"e_1_2_10_1_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.3.879"},{"key":"e_1_2_10_1_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734615569913"},{"key":"e_1_2_10_1_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2017.05.003"},{"key":"e_1_2_10_1_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12551"},{"key":"e_1_2_10_1_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01131.x"},{"key":"e_1_2_10_1_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8895"},{"key":"e_1_2_10_1_80_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678346"},{"key":"e_1_2_10_1_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1008-1275(08)60045-0"},{"key":"e_1_2_10_1_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5217967"},{"key":"e_1_2_10_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.11.033"},{"key":"e_1_2_10_1_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059193"},{"key":"e_1_2_10_1_85_1","first-page":"e52802","article-title":"Isolation and characterization of satellite cells from rat head branchiomeric muscles","volume":"101","author":"Carvajal Monroy PL","year":"2015","journal-title":"J Vis Exp"},{"key":"e_1_2_10_1_86_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790883453"},{"key":"e_1_2_10_1_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516679136"},{"key":"e_1_2_10_1_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22127"},{"issue":"5","key":"e_1_2_10_1_89_1","first-page":"779","article-title":"Muscle regeneration: cellular and molecular events","volume":"23","author":"Karalaki M","year":"2009","journal-title":"In Vivo"},{"key":"e_1_2_10_1_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<495::AID-AJA3>3.0.CO;2-C"},{"key":"e_1_2_10_1_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516679136"},{"key":"e_1_2_10_1_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000060102.57809.DA"},{"key":"e_1_2_10_1_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12098"},{"key":"e_1_2_10_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.11.002"},{"issue":"1","key":"e_1_2_10_1_95_1","first-page":"18","article-title":"The role of the TGF\u2010beta family in wound healing, burns and scarring: a review","volume":"2","author":"Penn JW","year":"2012","journal-title":"Int J Burns Trauma"},{"key":"e_1_2_10_1_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311907"},{"key":"e_1_2_10_1_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704146200"},{"key":"e_1_2_10_1_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000184163.61558.ca"},{"key":"e_1_2_10_1_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21371"},{"key":"e_1_2_10_1_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300250"},{"key":"e_1_2_10_1_101_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508315470"},{"key":"e_1_2_10_1_102_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.787"},{"key":"e_1_2_10_1_103_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1921"},{"key":"e_1_2_10_1_104_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4165"},{"key":"e_1_2_10_1_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63365-2"},{"key":"e_1_2_10_1_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1974"},{"key":"e_1_2_10_1_107_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1153"},{"key":"e_1_2_10_1_108_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060555"},{"key":"e_1_2_10_1_109_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6219"},{"key":"e_1_2_10_1_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12609"},{"key":"e_1_2_10_1_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3181"},{"key":"e_1_2_10_1_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076883"},{"key":"e_1_2_10_1_113_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0461"},{"key":"e_1_2_10_1_114_1","doi-asserted-by":"publisher","DOI":"10.1089\/10799900152547867"},{"key":"e_1_2_10_1_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.309"},{"key":"e_1_2_10_1_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12208"},{"key":"e_1_2_10_1_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.01.019"},{"key":"e_1_2_10_1_118_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-2044ED"},{"key":"e_1_2_10_1_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-3-16"},{"key":"e_1_2_10_1_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05194.x"},{"key":"e_1_2_10_1_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.05.012"},{"key":"e_1_2_10_1_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-016-9912-1"},{"key":"e_1_2_10_1_123_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6307"},{"key":"e_1_2_10_1_124_1","first-page":"4479","article-title":"Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor\u2010beta signaling pathway","volume":"9","author":"Herbertz S","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_10_1_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13945"},{"key":"e_1_2_10_1_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12845"},{"key":"e_1_2_10_1_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18844"},{"key":"e_1_2_10_1_128_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2581"},{"key":"e_1_2_10_1_129_1","doi-asserted-by":"publisher","DOI":"10.1042\/BC20060075"},{"key":"e_1_2_10_1_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.05.009"},{"key":"e_1_2_10_1_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.06.005"},{"key":"e_1_2_10_1_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2907"},{"key":"e_1_2_10_1_133_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196048"},{"key":"e_1_2_10_1_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0760-6"},{"key":"e_1_2_10_1_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0535-0"},{"key":"e_1_2_10_1_136_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2012-0041"},{"key":"e_1_2_10_1_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-013-9687-0"},{"key":"e_1_2_10_1_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.14"},{"key":"e_1_2_10_1_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines2010050"},{"key":"e_1_2_10_1_140_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2013.0664"},{"key":"e_1_2_10_1_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7472"},{"key":"e_1_2_10_1_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7484"},{"key":"e_1_2_10_1_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2017.03.001"},{"key":"e_1_2_10_1_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2005.08.020"},{"key":"e_1_2_10_1_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0292-y"},{"key":"e_1_2_10_1_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-6"},{"key":"e_1_2_10_1_147_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-4-617"},{"key":"e_1_2_10_1_148_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088348"},{"key":"e_1_2_10_1_149_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1472642"},{"issue":"5","key":"e_1_2_10_1_150_1","first-page":"134","article-title":"Umbilical cord mesenchymal stem cells combined with a collagenfibrin double\u2010layered membrane accelerates wound healing","volume":"27","author":"Nan W","year":"2015","journal-title":"Wounds"},{"key":"e_1_2_10_1_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2401"},{"key":"e_1_2_10_1_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt417"},{"key":"e_1_2_10_1_153_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl17035"},{"issue":"1","key":"e_1_2_10_1_154_1","first-page":"212","article-title":"Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis","volume":"10","author":"Meng M","year":"2018","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_1_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0102"},{"key":"e_1_2_10_1_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0042"},{"key":"e_1_2_10_1_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0474"},{"key":"e_1_2_10_1_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-016-0427-0"},{"key":"e_1_2_10_1_159_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2016-0157"},{"key":"e_1_2_10_1_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.09.018"},{"key":"e_1_2_10_1_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703800"},{"key":"e_1_2_10_1_162_1","first-page":"18057","article-title":"Umbilical cord\u2010derived mesenchymal stromal\/stem cells enhance recovery of surgically induced skeletal muscle ischemia in a rat model","author":"Arutyunyan I","year":"2018","journal-title":"Histol. Histopathol"},{"key":"e_1_2_10_1_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199607)19:7<853::AID-MUS7>3.0.CO;2-8"},{"key":"e_1_2_10_1_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017974"},{"key":"e_1_2_10_1_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-012-0331-9"},{"key":"e_1_2_10_1_166_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0607"},{"key":"e_1_2_10_1_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.022"},{"key":"e_1_2_10_1_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.079"},{"key":"e_1_2_10_1_169_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0304"},{"key":"e_1_2_10_1_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-011-0298-y"},{"key":"e_1_2_10_1_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.02.010"},{"key":"e_1_2_10_1_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00272"},{"key":"e_1_2_10_1_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11100"},{"key":"e_1_2_10_1_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02647.x"},{"key":"e_1_2_10_1_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.160"},{"key":"e_1_2_10_1_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200600351"},{"key":"e_1_2_10_1_177_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17121974"},{"key":"e_1_2_10_1_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12942"},{"key":"e_1_2_10_1_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.038"},{"key":"e_1_2_10_1_180_1","article-title":"Muscle fibrosis in the soft palate: delivery of cells, growth factors and anti\u2010fibrotics","author":"den Hoff JW","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"e_1_2_10_1_181_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb9010022"},{"key":"e_1_2_10_1_182_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00878.x"},{"key":"e_1_2_10_1_183_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-5950.196143"},{"key":"e_1_2_10_1_184_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b01445"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmed.21594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.21594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:47:18Z","timestamp":1694213238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,18]]},"references-count":183,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/med.21594"],"URL":"https:\/\/doi.org\/10.1002\/med.21594","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,18]]},"assertion":[{"value":"2019-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}