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Because drug resistance has been widely reported in fibrotic tissue and cancer, developing a strategy to discover novel targets for targeted drug intervention is necessary for the effective treatment of fibrosis and cancer. Although many factors lead to fibrosis and cancer, pathophysiological analysis has demonstrated that tissue fibrosis and cancer share a common process of epithelial\u2010mesenchymal transition (EMT). EMT is associated with many mediators, including transcription factors (Snail, zinc\u2010finger E\u2010box\u2010binding protein and signal transducer and activator of transcription 3), signaling pathways (transforming growth factor\u2010\u03b21, RAC\u2010\u03b1 serine\/threonine\u2010protein kinase, Wnt, nuclear factor\u2010kappa B, peroxisome proliferator\u2010activated receptor, Notch, and RAS), RNA\u2010binding proteins (ESRP1 and ESRP2) and microRNAs. Therefore, drugs targeting EMT may be a promising therapy against both fibrosis and tumors. A large number of compounds that are synthesized or derived from natural products and their derivatives suppress the EMT by targeting these mediators in fibrosis and cancer. By targeting EMT, these compounds exhibited anticancer effects in multiple cancer types, and some of them also showed antifibrotic effects. Therefore, drugs targeting EMT not only have both antifibrotic and anticancer effects but also exert effective therapeutic effects on multiorgan fibrosis and cancer, which provides effective therapy against fibrosis and cancer. Taken together, the results highlighted in this review provide new concepts for discovering new antifibrotic and antitumor drugs.<\/jats:p>","DOI":"10.1002\/med.21596","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T05:54:21Z","timestamp":1558936461000},"page":"54-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Small molecule inhibitors of epithelial\u2010mesenchymal transition for the treatment of cancer and fibrosis"],"prefix":"10.1002","volume":"40","author":[{"given":"Ya\u2010Long","family":"Feng","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Life Science &amp; Medicine Northwest University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u2010Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Life Science &amp; Medicine Northwest University Xi'an 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