{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:49:29Z","timestamp":1791920969151,"version":"4.3.4"},"reference-count":222,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:00:00Z","timestamp":1570924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["F16\u201001210"],"award-info":[{"award-number":["F16\u201001210"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["HOP\u2010143172"],"award-info":[{"award-number":["HOP\u2010143172"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The latency phenomenon produced by human immunodeficiency virus (HIV\u20101) prevents viral clearance by current therapies, and consequently development of a cure for HIV\u20101 disease represents a formidable challenge. Research over the past decade has resulted in identification of small molecules that are capable of exposing HIV\u20101 latent reservoirs, by reactivation of viral transcription, which is intended to render these infected cells sensitive to elimination by immune defense recognition or apoptosis. Molecules with this capability, known as latency\u2010reversing agents (LRAs) could lead to realization of proposed HIV\u20101 cure strategies collectively termed \u201cshock and kill,\u201d which are intended to eliminate the latently infected population by forced reactivation of virus replication in combination with additional interventions that enhance killing by the immune system or virus\u2010mediated apoptosis. Here, we review efforts to discover novel LRAs via low\u2010 and high\u2010throughput small molecule screens, and summarize characteristics and biochemical properties of chemical structures with this activity. We expect this analysis will provide insight toward further research into optimized designs for new classes of more potent LRAs.<\/jats:p>","DOI":"10.1002\/med.21638","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T03:35:41Z","timestamp":1571024141000},"page":"881-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Diversity of small molecule HIV\u20101 latency reversing agents identified in low\u2010 and high\u2010throughput small molecule screens"],"prefix":"10.1002","volume":"40","author":[{"given":"Pargol","family":"Hashemi","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology, Molecular Epigenetics, Life Sciences Institute University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-710X","authenticated-orcid":false,"given":"Ivan","family":"Sadowski","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, Molecular Epigenetics, Life Sciences Institute University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/387183a0"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1972"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15109"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007096"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.10958"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.02.021"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2018.02.007"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212522"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30039-0"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30931-6"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.07.001"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162043484915"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/487439a"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X14666160324125536"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-052716-031710"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000279"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.014"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009390"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(14)70014-1"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005142"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003834"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3489"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02842-15"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00793-12"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-014-0336-9"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250220"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07814-4"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708193"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009390"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2011.00975.x"},{"key":"e_1_2_8_1_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282fd6ddc"},{"key":"e_1_2_8_1_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000238421.36313.fa"},{"key":"e_1_2_8_1_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-52"},{"issue":"11","key":"e_1_2_8_1_35_1","first-page":"3473","article-title":"Small\u2010molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation","volume":"119","author":"Yang HC","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_8_1_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.195537"},{"key":"e_1_2_8_1_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02033-10"},{"key":"e_1_2_8_1_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr496"},{"key":"e_1_2_8_1_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05972-11"},{"key":"e_1_2_8_1_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084964"},{"key":"e_1_2_8_1_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0190-4"},{"key":"e_1_2_8_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.11.047"},{"key":"e_1_2_8_1_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0637-9"},{"key":"e_1_2_8_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.022"},{"key":"e_1_2_8_1_45_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000716"},{"key":"e_1_2_8_1_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07157-0"},{"key":"e_1_2_8_1_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21942-5"},{"key":"e_1_2_8_1_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10070348"},{"key":"e_1_2_8_1_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070779"},{"key":"e_1_2_8_1_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006093"},{"key":"e_1_2_8_1_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000067"},{"key":"e_1_2_8_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.02.005"},{"key":"e_1_2_8_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2017.10.003"},{"key":"e_1_2_8_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25207"},{"key":"e_1_2_8_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.07.001"},{"key":"e_1_2_8_1_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2np00066k"},{"key":"e_1_2_8_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.03.071"},{"key":"e_1_2_8_1_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2007.6"},{"key":"e_1_2_8_1_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2016182"},{"key":"e_1_2_8_1_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02056-17"},{"key":"e_1_2_8_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.12.037"},{"key":"e_1_2_8_1_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1471"},{"key":"e_1_2_8_1_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00084"},{"key":"e_1_2_8_1_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2445"},{"key":"e_1_2_8_1_65_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780162827"},{"key":"e_1_2_8_1_66_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.060673"},{"key":"e_1_2_8_1_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9090"},{"key":"e_1_2_8_1_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04067.x"},{"key":"e_1_2_8_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90291-7"},{"key":"e_1_2_8_1_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi973162p"},{"key":"e_1_2_8_1_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.3.767"},{"key":"e_1_2_8_1_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.808"},{"key":"e_1_2_8_1_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283570620"},{"key":"e_1_2_8_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(96)00767-8"},{"key":"e_1_2_8_1_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.127"},{"key":"e_1_2_8_1_76_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005538"},{"issue":"1","key":"e_1_2_8_1_77_1","first-page":"17","article-title":"PKC412\u2010a protein kinase inhibitor with a broad therapeutic potential","volume":"15","author":"Fabbro D","year":"2000","journal-title":"Anticancer Drug Des"},{"key":"e_1_2_8_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00069-7"},{"key":"e_1_2_8_1_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404438101"},{"key":"e_1_2_8_1_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-014092"},{"key":"e_1_2_8_1_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/6.2.213"},{"key":"e_1_2_8_1_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.9672"},{"key":"e_1_2_8_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2005.01.012"},{"key":"e_1_2_8_1_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.28.16455"},{"key":"e_1_2_8_1_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101287200"},{"key":"e_1_2_8_1_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.00104.x"},{"key":"e_1_2_8_1_87_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.5.659"},{"key":"e_1_2_8_1_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e31803c73cc"},{"key":"e_1_2_8_1_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20532"},{"key":"e_1_2_8_1_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0303094"},{"key":"e_1_2_8_1_91_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2008.0191"},{"key":"e_1_2_8_1_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510341103"},{"key":"e_1_2_8_1_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006093"},{"key":"e_1_2_8_1_94_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505557"},{"key":"e_1_2_8_1_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja7110064"},{"key":"e_1_2_8_1_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja205972n"},{"key":"e_1_2_8_1_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-016-9600-6"},{"key":"e_1_2_8_1_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2007.00594.x"},{"key":"e_1_2_8_1_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks976"},{"key":"e_1_2_8_1_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.07.025"},{"key":"e_1_2_8_1_101_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016208785132563"},{"key":"e_1_2_8_1_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05994.x"},{"key":"e_1_2_8_1_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05994.x"},{"key":"e_1_2_8_1_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00449.x"},{"key":"e_1_2_8_1_105_1","doi-asserted-by":"publisher","DOI":"10.4161\/trns.20541"},{"key":"e_1_2_8_1_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002302"},{"key":"e_1_2_8_1_107_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057112455060"},{"key":"e_1_2_8_1_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.7.1623"},{"key":"e_1_2_8_1_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.01.008"},{"key":"e_1_2_8_1_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.04.011"},{"key":"e_1_2_8_1_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07761.x"},{"key":"e_1_2_8_1_112_1","volume-title":"Free Radicals in Biology and Medicine","author":"Halliwell B","year":"1999"},{"key":"e_1_2_8_1_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07761.x"},{"key":"e_1_2_8_1_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf660"},{"key":"e_1_2_8_1_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.08.114"},{"key":"e_1_2_8_1_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(79)90289-3"},{"key":"e_1_2_8_1_117_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5185-5188.2005"},{"key":"e_1_2_8_1_118_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA01216D"},{"key":"e_1_2_8_1_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030146"},{"key":"e_1_2_8_1_120_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807898200"},{"key":"e_1_2_8_1_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1983.70"},{"key":"e_1_2_8_1_122_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3752"},{"key":"e_1_2_8_1_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1992.tb03310.x"},{"key":"e_1_2_8_1_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1220"},{"key":"e_1_2_8_1_125_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.70.65"},{"key":"e_1_2_8_1_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404438101"},{"key":"e_1_2_8_1_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208989"},{"key":"e_1_2_8_1_128_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-014092"},{"key":"e_1_2_8_1_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.09.063"},{"key":"e_1_2_8_1_130_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2533"},{"key":"e_1_2_8_1_131_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.13077-13082.2002"},{"key":"e_1_2_8_1_132_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81400"},{"key":"e_1_2_8_1_133_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005545"},{"key":"e_1_2_8_1_134_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874357920130621001"},{"key":"e_1_2_8_1_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2233345100"},{"key":"e_1_2_8_1_136_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01391.x"},{"key":"e_1_2_8_1_137_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.042762"},{"key":"e_1_2_8_1_138_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/805347"},{"key":"e_1_2_8_1_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2007"},{"key":"e_1_2_8_1_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.13.4868"},{"key":"e_1_2_8_1_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00405a053"},{"key":"e_1_2_8_1_142_1","first-page":"31","volume-title":"Progress in Molecular Biology and Translational Science","author":"Sun M","year":"2014"},{"key":"e_1_2_8_1_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.9672"},{"key":"e_1_2_8_1_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/6.2.213"},{"issue":"7","key":"e_1_2_8_1_145_1","first-page":"2807","article-title":"Inhibition of glycoprotein biosynthesis by the inducers of HL\u201060 cell differentiation, aclacinomycin A and marcellomycin","volume":"44","author":"Morin MJ","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_8_1_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00141291"},{"key":"e_1_2_8_1_147_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503673200"},{"key":"e_1_2_8_1_148_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018985"},{"key":"e_1_2_8_1_149_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039481"},{"key":"e_1_2_8_1_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12863"},{"key":"e_1_2_8_1_151_1","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1502-01"},{"key":"e_1_2_8_1_152_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.013755"},{"key":"e_1_2_8_1_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2012.02.004"},{"key":"e_1_2_8_1_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00339"},{"key":"e_1_2_8_1_155_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01437"},{"key":"e_1_2_8_1_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/128_2011_180"},{"key":"e_1_2_8_1_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.05.007"},{"key":"e_1_2_8_1_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527630035"},{"key":"e_1_2_8_1_159_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006740"},{"key":"e_1_2_8_1_160_1","article-title":"The SMAC mimetic AZD5582 is a potent HIV latency reversing agent","author":"Sampey GC","year":"2018","journal-title":"bioRxiv"},{"key":"e_1_2_8_1_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.08.009"},{"key":"e_1_2_8_1_162_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207317666140122101631"},{"key":"e_1_2_8_1_163_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00284A"},{"key":"e_1_2_8_1_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00120a002"},{"key":"e_1_2_8_1_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.02.018"},{"key":"e_1_2_8_1_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118686263"},{"key":"e_1_2_8_1_167_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0312165"},{"key":"e_1_2_8_1_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.09.008"},{"key":"e_1_2_8_1_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4011302"},{"key":"e_1_2_8_1_170_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.117341"},{"key":"e_1_2_8_1_171_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1738-05.2005"},{"key":"e_1_2_8_1_172_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536012115624920"},{"key":"e_1_2_8_1_173_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 1224823; SID 312345101.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/1224823#sid=312345101. Accessed April 3 2019."},{"key":"e_1_2_8_1_174_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 1224820; SID 312345101.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/1224820#sid=312345101. Accessed April 3 2019."},{"key":"e_1_2_8_1_175_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 1458; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/1458#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_176_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 884; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/884#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_177_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 540276; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/540276#sid=26753630. Accessed Apl. 3 2019."},{"key":"e_1_2_8_1_178_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 1224857; SID 312345101.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/1224857#sid=312345101. Accessed April 3 2019."},{"key":"e_1_2_8_1_179_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 524791; SID 123100907.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/524791#sid=123100907. Accessed April 3 2019."},{"key":"e_1_2_8_1_180_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 524794; SID 123100907.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/524794#sid=123100907. Accessed April 3 2019."},{"key":"e_1_2_8_1_181_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 524796; SID 123100907.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/524796#sid=123100907. Accessed April 3 2019."},{"key":"e_1_2_8_1_182_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 945; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/945#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_183_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 958; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/958#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_184_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 463097; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/463097#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_185_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 893; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/893#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_186_1","unstructured":"PubChem database.Bethesda MD: National Center for Biotechnology Information. Bioactivity: AID 504332; SID 26753630.https:\/\/pubchem.ncbi.nlm.nih.gov\/bioassay\/504332#sid=26753630. Accessed April 3 2019."},{"key":"e_1_2_8_1_187_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/805347"},{"key":"e_1_2_8_1_188_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0100389"},{"key":"e_1_2_8_1_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.95"},{"key":"e_1_2_8_1_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404464"},{"key":"e_1_2_8_1_191_1","first-page":"2","article-title":"Tat, a novel regulator of HIV transcription and latency","volume":"2000","author":"Karn J","year":"2000","journal-title":"HIV Seq Compendium"},{"key":"e_1_2_8_1_192_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-011-9267-6"},{"key":"e_1_2_8_1_193_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks976"},{"key":"e_1_2_8_1_194_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01035"},{"key":"e_1_2_8_1_195_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-101416-041646"},{"key":"e_1_2_8_1_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.02.008"},{"key":"e_1_2_8_1_197_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01435"},{"key":"e_1_2_8_1_198_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000408"},{"key":"e_1_2_8_1_199_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6041837"},{"key":"e_1_2_8_1_200_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000279"},{"key":"e_1_2_8_1_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.22"},{"key":"e_1_2_8_1_202_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw189"},{"key":"e_1_2_8_1_203_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018270"},{"key":"e_1_2_8_1_204_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn5002694"},{"key":"e_1_2_8_1_205_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0500-4"},{"key":"e_1_2_8_1_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.06.002"},{"key":"e_1_2_8_1_207_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI92684"},{"key":"e_1_2_8_1_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00226-X"},{"key":"e_1_2_8_1_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.12.004"},{"key":"e_1_2_8_1_210_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.9698-9705.1998"},{"key":"e_1_2_8_1_211_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005782"},{"key":"e_1_2_8_1_212_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005349"},{"key":"e_1_2_8_1_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05115"},{"key":"e_1_2_8_1_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14053"},{"key":"e_1_2_8_1_215_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00506"},{"key":"e_1_2_8_1_216_1","doi-asserted-by":"publisher","DOI":"10.1615\/ForumImmunDisTher.2016015242"},{"key":"e_1_2_8_1_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0242-8"},{"key":"e_1_2_8_1_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30039-0"},{"key":"e_1_2_8_1_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30490-8"},{"key":"e_1_2_8_1_220_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000293"},{"key":"e_1_2_8_1_221_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.7.1139"},{"key":"e_1_2_8_1_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-017-0604-2"},{"key":"e_1_2_8_1_223_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00397"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.21638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:36:58Z","timestamp":1694050618000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,13]]},"references-count":222,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/med.21638"],"URL":"https:\/\/doi.org\/10.1002\/med.21638","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,13]]},"assertion":[{"value":"2019-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}