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Artemisinin (ART), a sesquiterpene lactone endoperoxide isolated from traditional Chinese herb <jats:italic>Artemisia annua<\/jats:italic>, has been recognized as a novel class of antimalarial drugs. The 2015 \u201cNobel Prize in Physiology or Medicine\u201d was given to Prof Dr Tu Youyou for the discovery of ART. Hence, ART is termed as \u201cNobel medicine.\u201d The present review article accommodates insights from the chronological advancements and direct statistics witnessed during the past 48 years (1971\u20102019) in the medicinal chemistry of ART\u2010derived antimalarial endoperoxides, and their clinical utility in malaria chemotherapy and drug discovery.<\/jats:p>","DOI":"10.1002\/med.21657","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T07:30:10Z","timestamp":1578900610000},"page":"1220-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Artemisinin\u2010derived antimalarial endoperoxides from bench\u2010side to bed\u2010side: Chronological advancements and future challenges"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-1986","authenticated-orcid":false,"given":"Mohit K.","family":"Tiwari","sequence":"first","affiliation":[{"name":"Laboratory of Organic and Medicinal Chemistry, Department of Chemistry Malaviya National Institute of Technology Jaipur  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-3895","authenticated-orcid":false,"given":"Sandeep","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Medicinal Chemistry, Department of Chemistry Malaviya National Institute of Technology Jaipur  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,12]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/181353"},{"issue":"3","key":"e_1_2_16_3_1","first-page":"548","article-title":"Culex malariager, n. sp. 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