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There is a growing concern on less available anthelmintics and the emergence of resistance creating a major threat to human and livestock health resources. Novel and broad\u2010spectrum anthelmintics are urgently needed. The free\u2010living nematode <jats:italic>Caenorhabditis elegans<\/jats:italic> could address this issue through automated high\u2010throughput technologies for the screening of large chemical libraries. This review discusses the strong advantages and limitations for using <jats:italic>C elegans<\/jats:italic> as a screening method for anthelmintic drug discovery. <jats:italic>C elegans<\/jats:italic> is the best model available for the validation of novel effective drugs in treating most, if not all, helminth infections, and for the elucidation the mode of action of anthelmintic candidates. 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