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Natural drugs are important alternative therapies in the treatment of and recovery from influenza and have been the subjects of intense investigation during the last few decades. Many reports have shown that the development of novel bioactive chemicals extracted from natural drugs has significant advantages. Oseltamivir is a successful case of an anti\u2010influenza drug synthesized using two natural products, quinic acid, and shikimic acid, as starting materials. In China, traditional Chinese medicine (TCM) plays an important role in the treatment of influenza. TCM herbal extracts and prescriptions or their isolated bioactive constituents have shown significant therapeutic and preventive effects against influenza. For example, the roots of <jats:italic>Isatis indigotica<\/jats:italic> (Banlangen) fight viral infection by targeting both the virus and the host and have significantly different effects than those of synthetic chemicals. <jats:italic>Lianhuaqingwen<\/jats:italic>\u00a0capsule exerts its anti\u2010influenza activity by regulating the immune response to interfere with both viral and host reactions and might well be an alternative therapeutic option to treat influenza virus infection.\u00a0This paper reviews the chemical ingredients, crude extracts, and TCM prescriptions with anti\u2010influenza activity reported during the period of 2010\u2013September 2019. We hope that this comprehensive review will not only fuel research on anti\u2010influenza active natural products and TCM research but also provide a promising alternative candidate for further anti\u2010influenza drug development.<\/jats:p>","DOI":"10.1002\/med.21707","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T06:32:38Z","timestamp":1594967558000},"page":"2290-2338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Development of anti\u2010influenza agents from natural products"],"prefix":"10.1002","volume":"40","author":[{"given":"Zhi\u2010Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Faculty of Life Science and Technology Kunming University of Science and Technology Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Morris\u2010Natschke","sequence":"additional","affiliation":[{"name":"Natural Products 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