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Inflammation is the main culprit for the development of cardiovascular dysfunction, and it may be traced to cellular stress events including apoptosis, oxidative and shear stress, and cellular and humoral immune responses, all of which impair the system's structure and function. An intracellular chaperone, heat shock protein 60 (HSP60) is an intriguing example of a protein that may both be an ally and a foe for cardiovascular homeostasis; on one hand providing protection against cellular injury, and on the other triggering damaging responses through innate and adaptive immunity. In this review we will discuss the functions of HSP60 and its effects on cells and the immune system regulation, only to later address its implications in the development and progression of CVD. Lastly, we summarize the outcome of various studies targeting HSP60 as a potential therapeutic strategy for cardiovascular and other diseases.<\/jats:p>","DOI":"10.1002\/med.21723","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:45:00Z","timestamp":1598575500000},"page":"29-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Heat shock protein 60 and cardiovascular diseases: An intricate love\u2010hate story"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3314-2609","authenticated-orcid":false,"given":"Indumathi","family":"Krishnan\u2010Sivadoss","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabol\u00f3mica Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n A.","family":"Mijares\u2010Rojas","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabol\u00f3mica Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro A.","family":"Villarreal\u2010Leal","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabol\u00f3mica Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Torre\u2010Amione","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabol\u00f3mica Monterrey Nuevo Le\u00f3n M\u00e9xico"},{"name":"Methodist DeBakey Heart and Vascular Center, The Methodist Hospital Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne A.","family":"Knowlton","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center Sacramento California USA"},{"name":"Department of Internal Medicine, Molecular and Cellular Cardiology, Cardiovascular Division University of California Davis California USA"},{"name":"Department of Pharmacology University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5001-0093","authenticated-orcid":false,"given":"C. 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