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The destruction of melanocyte is thought to be of multifactorial causation. Genome\u2010wide associated studies have identified single\u2010nucleotide polymorphisms in a panel of susceptible loci as risk factors in melanocyte death. But vitiligo onset can't be solely attributed to a susceptive genetic background. Oxidative stress triggered by elevated levels of reactive oxygen species accounts for melanocytic molecular and organelle dysfunction, a minority of melanocyte demise, and melanocyte\u2010specific antigens exposure. Of note, the self\u2010responsive immune function directly contributes to the bulk of melanocyte deaths in vitiligo. The aberrantly heightened innate immunity, type\u20101\u2010skewed T helper, and incompetent regulatory T cells tip the balance toward\u00a0autoreaction\u00a0and CD8\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic T lymphocytes finally execute the killing of melanocytes, possibly alarmed by resident memory T cells. In addition to the well\u2010established apoptosis and necrosis, we discuss several death modalities like oxeiptosis, ferroptosis, and necroptosis that are probably employed in melanocyte destruction. This review focuses on the various mechanisms of melanocytic death in vitiligo pathogenesis to demonstrate a panorama of that. We hope to provide new insights into vitiligo pathogenesis and treatment strategies by the review.\n                  <\/jats:p>","DOI":"10.1002\/med.21754","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T06:11:13Z","timestamp":1605593473000},"page":"1138-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":281,"title":["Mechanisms of melanocyte death in vitiligo"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-5128","authenticated-orcid":false,"given":"Jianru","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing hospital, Fourth Military Medical University Xi'an Shannxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-507X","authenticated-orcid":false,"given":"Shuli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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