{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:49:00Z","timestamp":1788389340258,"version":"build-2803163510"},"reference-count":233,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cistanches Herba (CH, Chinese name:\n                    <jats:italic>Roucongrong<\/jats:italic>\n                    ), is a very precious, tonic Chinese medicine.\n                    <jats:italic>Cistanche deserticola<\/jats:italic>\n                    and\n                    <jats:italic>Cistanche tubulosa<\/jats:italic>\n                    are the two commonly used species and authenticated in Chinese Pharmacopoeia. Due to the parasitic nature of\n                    <jats:italic>Cistanche<\/jats:italic>\n                    plants, the wild source was once endangered and listed in the Appendix II of Convention on International Trade in Endangered Species of Wild Fauna and Flora. However, after continuously struggling in the past decades, CH has grown up to a big brand of Chinese medicine featured with the cultivation area as 1.26 million mu, the annual output as 6000 tons, and the related industrial output value as more than 20 billion China Yuan, attributing to large\u2010scale cultivation and in\u2010depth phytochemical and pharmacological investigations. Noteworthily, great achievements have reached concerning the research and development of relevant products, such as modern drugs, traditional Chinese medicine prescriptions, and dietary supplements. The current review summarizes the research progresses concerning the distribution and cultivation, phytochemistry, pharmacology, metabolism and product development of CH in the past decades, and the emerging challenges and developing prospects are discussed as well.\n                  <\/jats:p>","DOI":"10.1002\/med.21768","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T02:00:10Z","timestamp":1612144810000},"page":"1539-1577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Cistanches Herba, from an endangered species to a big brand of Chinese medicine"],"prefix":"10.1002","volume":"41","author":[{"given":"Yuelin","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University Beijing China"},{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewu","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-8174","authenticated-orcid":false,"given":"Pengfei","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University Beijing China"},{"name":"Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,31]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Herbal textual research on classical prescription of Cistanches Herba","author":"Weng QQ","year":"2020","journal-title":"Zhongguo Xiandai Zhongyao"},{"key":"e_1_2_11_3_1","first-page":"126","volume-title":"Pharmacopoeia of the People's Republic of China","author":"The Commission of Chinese Pharmacopoeia","year":"2010"},{"key":"e_1_2_11_4_1","first-page":"895","volume-title":"Dictionary of Traditional Chinese Medicine","author":"Jiangsu New Medical College","year":"1977"},{"issue":"5","key":"e_1_2_11_5_1","first-page":"473","article-title":"Advances in research of chemical constituents in plants of Cistanche Hoffing. et Link","volume":"34","author":"Lei L","year":"2003","journal-title":"Chin Tradit Herb Drugs"},{"key":"e_1_2_11_6_1","first-page":"41","article-title":"Advances in the chemistry and pharmacology of Cistanchis Herba","volume":"34","author":"Chen S","year":"2005","journal-title":"Gansu Animal Vet Sci"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c20-00057"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0720"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c19-00008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.031"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X12500838"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00041"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00289"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.10.015"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"29","article-title":"Study on the status quo of Cistanche deserticola and its exploitation and utilization in China","volume":"33","author":"Tan DY","year":"2004","journal-title":"Forest Resour Manage"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"56","article-title":"Interference control and chip waveform design in multirate DS\u2010CDMA communication systems","volume":"1","author":"Luo TB","year":"2002","journal-title":"Arid Zone Res"},{"issue":"1","key":"e_1_2_11_17_1","first-page":"4","article-title":"Herbalogical studies on rou congrong (herba Cistanchis)","volume":"19","author":"Tu PF","year":"1994","journal-title":"China J Chin Materia Medica"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"32","article-title":"A new variety of Cistanche Salsa from Ningxia","volume":"14","author":"Tu PF","year":"1994","journal-title":"China. 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