{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:00Z","timestamp":1790740020590,"version":"4.1.0"},"reference-count":148,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21907102"],"award-info":[{"award-number":["21907102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21632008"],"award-info":[{"award-number":["21632008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91229204"],"award-info":[{"award-number":["91229204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473245"],"award-info":[{"award-number":["81473245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772695"],"award-info":[{"award-number":["81772695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a key adaptor protein that regulates the NF\u2010\u03baB pathway, in which MALT1 functions as a scaffold protein and protease to trigger downstream signals. The abnormal expression of MALT1 is closely associated with lymphomagenesis and other diseases, including solid tumors and autoimmune diseases. MALT1 is the only protease in the underlying pathogenesis of these diseases, and its proteolytic activity can be pharmacologically regulated. Therefore, MALT1 is a potential and promising target for anti\u2010lymphoma and other MALT1\u2010related disease treatments. Currently, the development of MALT1 inhibitors is still in its early stages. This review presents an overview of MALT1, particularly its X\u2010ray structures and biological functions, and elaborates on the pathogenesis of diseases associated with its dysregulation. We then summarize previously reported MALT1 inhibitors, focusing on their molecular structure, biological activity, structure\u2013activity relationship, and limitations. Finally, we propose future research directions to accelerate the discovery of novel MALT1 inhibitors with clinical applications. Overall, this review provides a comprehensive and systematic overview of MALT1\u2010related research advances and serves as a theoretical basis for drug discovery and research.<\/jats:p>","DOI":"10.1002\/med.21799","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T08:03:59Z","timestamp":1616659439000},"page":"2388-2422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-9242","authenticated-orcid":false,"given":"Xuewu","family":"Liang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiChun","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunpu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology, Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-6268","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1987.tb02654.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C"},{"key":"e_1_2_12_5_1","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.5.1796.1796"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008202303666"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3601"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00086-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02414-0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010512200"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103824200"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1561"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1568"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.85"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198946"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105020108"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3008"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103774"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6908"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9777"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.02.018"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111708108"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023220"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091167"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907511106"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.11.002"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.11.003"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01415"},{"key":"e_1_2_12_31_1","unstructured":"KarolinaE SofiaK BjoernK StinaL AasaR LourdesSO inventors. Preparation of pyrazolopyrimidines as MALT\u20101 inhibitors for the treatment of cancer. PCT Int Appl. WO 2018226150A1. 13 December 2018."},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0222-1"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06573-8"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.03.006"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800670200"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00236-9"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611038200"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02273"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.04.012"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601897"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2540"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072051"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009984200"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210342"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.195"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2963"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-008-0005-9"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231465798"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120035"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141324"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-123513"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01136"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01539"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1352"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902438"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003004"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721967115"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601897"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2338"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000726200"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02167"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.03.1503"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01927"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04926"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001259"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0084-6"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.032"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.12.020"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.77"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803313"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601502200"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800032200"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031377"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.10.009"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02504-2"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.43"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.12.018"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.08.007"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18610.x"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301945200"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.11.7688"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.034"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1821"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.565"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33047"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182378"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-019927"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169026"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11292"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.029"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12336"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.010"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02264-0"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401845"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-062913-051343"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80953-8"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.11.2099"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.12.007"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0467"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1409"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3167"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0702"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4590"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-192583"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000518"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05168-7"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403185"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64630-5"},{"issue":"6","key":"e_1_2_12_109_1","first-page":"1526","article-title":"Research progress on the etiology and pathogenesis of MALT lymphoma","volume":"20","author":"Wang XC","year":"2012","journal-title":"J Exp Hematol."},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711335115"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1732008100"},{"issue":"1","key":"e_1_2_12_112_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1158\/1078-0432.28.11.1","article-title":"Small molecule inhibitors of I\u03baB kinase are selectively toxic for subgroups of diffuse large B\u2010cell lymphoma defined by gene expression profiling","volume":"11","author":"Lam LT","year":"2005","journal-title":"Clin Cancer Res"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08638"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208075"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153629"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507459112"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0406-370"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.31"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01998-5"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23693"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000257"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.239"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031467"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110480200"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.68"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2016.13"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2015.30"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.146"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2088"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.014"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63528"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.021"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201351"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12349-9"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.09.010"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201304290"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.12.022"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.04.059"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.10.009"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.11.011"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.05.017"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b00871"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0101-6"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0047-y"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2168-1"},{"key":"e_1_2_12_146_1","unstructured":"Melnick AriM FontanGL IlkayU et al. Prepartion of 1 3\u2010disubstituted ureas as bifunctional compounds as MALT1 degraders for treatment of hematological cancers. PCT Int. Appl. WO 2018085247A1. 11 May 2018."},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.1018"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00745"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.12.004"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.21799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:22:42Z","timestamp":1693423362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":148,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/med.21799"],"URL":"https:\/\/doi.org\/10.1002\/med.21799","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,25]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}