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Our understanding of CCs in cell signaling, organelle function, cellular homeostasis, and cell cycle control has led to improved insights into their structure and functions. In this article, we discuss CCs characteristics of five major protozoan parasites <jats:italic>Plasmodium<\/jats:italic>, <jats:italic>Leishmania<\/jats:italic>, <jats:italic>Toxoplasma<\/jats:italic>, <jats:italic>Trypanosoma<\/jats:italic>, and <jats:italic>Cryptosporidium<\/jats:italic>. We provide a comprehensive review of current antiparasitic drugs and the potential of using CCs as new therapeutic targets. Interestingly, previous studies have demonstrated that human CC modulators can kill or sensitize parasites to antiparasitic drugs. Still, none of the parasite CCs, pumps, or transporters has been validated as drug targets. Information for this review draws from extensive data mining of genome sequences, chemical library screenings, and drug design studies. 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