{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:44:54Z","timestamp":1781189094691,"version":"3.54.1"},"reference-count":161,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019M3D1A1078940"],"award-info":[{"award-number":["NRF\u20102019M3D1A1078940"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1A6A1A11051471"],"award-info":[{"award-number":["NRF\u20102019R1A6A1A11051471"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1F1A1071517"],"award-info":[{"award-number":["NRF\u20102020R1F1A1071517"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RNA viruses, including the coronavirus, develop a unique strategy to evade the host immune response by interrupting the normal function of cytosolic retinoic acid\u2010inducible gene\u2010I (RIG\u2010I)\u2010like receptors (RLRs). RLRs rapidly detect atypical nucleic acids, thereby triggering the antiviral innate immune signaling cascade and subsequently activates the interferons transcription and induction of other proinflammatory cytokines and chemokines. Nonetheless, these receptors are manipulated by viral proteins to subvert the host immune system and sustain the infectivity and replication potential of the virus. RIG\u2010I senses the single\u2010stranded, double\u2010stranded, and short double\u2010stranded RNAs and recognizes the key signature, a 5\u2032\u2010triphosphate moiety, at the blunt end of the viral RNA. Meanwhile, the melanoma differentiation\u2010associated gene 5 (MDA5) is triggered by longer double stranded RNAs, messenger RNAs lacking 2\u2032\u2010<jats:italic>O<\/jats:italic>\u2010methylation in their 5\u2032\u2010cap, and RNA aggregates. Therefore, structural insights into the nucleic\u2010acid\u2010sensing and downstream signaling mechanisms of these receptors hold great promise for developing effective antiviral therapeutic interventions. This review highlights the critical roles played by RLRs in viral infections as well as their ligand recognition mechanisms. In addition, we highlight the crosstalk between the toll\u2010like receptors and RLRs and provide a comprehensive overview of RLR\u2010associated diseases as well as the therapeutic potential of RLRs for the development of antiviral\u2010drugs. Moreover, we believe that these RLR\u2010based antivirals will serve as a step toward countering the recent coronavirus disease 2019 pandemic.<\/jats:p>","DOI":"10.1002\/med.21845","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T07:52:35Z","timestamp":1626853955000},"page":"399-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Structural insights into the distinctive RNA recognition and therapeutic potentials of RIG\u2010I\u2010like receptors"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0331-1317","authenticated-orcid":false,"given":"Maria","family":"Batool","sequence":"first","affiliation":[{"name":"Department of Molecular Science and Technology Ajou University  Suwon Korea"},{"name":"S&amp;K Therapeutics Campus Plaza 418, Ajou University Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular Science and Technology Ajou University  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-7848","authenticated-orcid":false,"given":"Sangdun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Molecular Science and Technology Ajou University  Suwon Korea"},{"name":"S&amp;K Therapeutics Campus Plaza 418, Ajou University Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3787"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25685"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618310114"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.76"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11736-6"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17665-9"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10040146"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.003"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.10.007"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00342"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01379"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.12.003"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.007179"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2012.02.006"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1087"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.10.032"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp059"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.424416"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912986107"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6444"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5260"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00445-10"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04734"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01080-07"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.06.005"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.041"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.018"},{"key":"e_1_2_16_32_1","first-page":"662","article-title":"Host and viral modulation of RIG\u2010I\u2010mediated antiviral immunity","volume":"7","author":"Liu Y","year":"2016","journal-title":"Front Immunol"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2007.12.002"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2975"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst184"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.22706"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.023"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.035949.112"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.11.028"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.048"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.19"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113651108"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.07.024"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2012.09.003"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603082103"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0299-y"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020182"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1779"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606699104"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01199-08"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00155-10"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000279"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01305-07"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-013-0740-7"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132505"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000108"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.007"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2013.06.007"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1979"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03370-13"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01586"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3776"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00770-09"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080091"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.015"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1921485117"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00884-1"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212186109"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.027"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2011.630974"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01325-06"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064202"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.07.003"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02449-08"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13590"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07106"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.039"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.06.015"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06042"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.385146"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10537"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2333"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.10.005"},{"issue":"20","key":"e_1_2_16_84_1","first-page":"4761","article-title":"Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses","volume":"125","author":"Triantafilou K","year":"2012","journal-title":"J Cell Sci"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.029"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2011.04.004"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01187"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05732"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.11.008"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00602-7"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.020"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604277113"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611551104"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1963"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.136"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1145918"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901646"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1815"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704014104"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700544104"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00548.x"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2016.18"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2038"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2307"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000480"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001178"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000757"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.006"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1824"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1749"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2851"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.10.002"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.09.015"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2014.909455"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167728"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.014"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.05.008"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1920"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00810"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112783"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3611"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06309"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-100008"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2017.08.004"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02174-09"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.009"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1029698"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2142"},{"issue":"8","key":"e_1_2_16_132_1","first-page":"2399","article-title":"Proapoptotic signaling induced by RIG\u2010I and MDA\u20105 results in type I interferon\u2010independent apoptosis in human melanoma cells","volume":"119","author":"Besch R","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2693"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010329"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.08.013"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199606000-00006"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq071"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70025-7"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-3106"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0459-2"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0295-5"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2817"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0089"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1790"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058273"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1887"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25626"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24809"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.955687"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0288-3"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008670"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01594-17"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.11.021"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28354"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.040"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744480"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043031"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02143-16"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0514-8"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108185"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00571-x"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00438-7"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.21845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:46:55Z","timestamp":1692985615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":161,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/med.21845"],"URL":"https:\/\/doi.org\/10.1002\/med.21845","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"assertion":[{"value":"2020-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}