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Besides the role of \u03b22\u2010ARs, preclinical studies in ROP have also revealed that \u03b23\u2010ARs are upregulated by hypoxia and that they are possibly involved in retinal angiogenesis. In a sort of figurative round trip, peculiarities typical of ROP, where hypoxia drives retinal neovascularization, have been then translated to cancer, a disease equally characterized by hypoxia\u2010driven angiogenesis. In this step, investigating the role of \u03b23\u2010ARs has taken advantage of the assumption that cancer growth uses a set of strategies in common with embryo development. The possibility that hypoxic induction of \u03b23\u2010ARs may represent one of the mechanisms through which primarily embryo (and then cancer, as an astute imitator) adapts to grow in an otherwise hostile environment, has grown evidence. In both cancer and embryo, \u03b23\u2010ARs exert similar functions by exploiting a metabolic shift known as the Warburg effect, by acquiring resistance against xenobiotics, and by inducing a local immune tolerance. An additional potential role of \u03b23\u2010AR as a marker of stemness has been suggested by the finding that its antagonism induces cancer cell differentiation evoking that \u03b23\u2010ARs may help cancer to grow in a nonhospital environment, a strategy also exploited by embryos. From cancer, the round trip goes back to neonatal diseases for which new possible interpretative keys and potential pharmacological perspectives have been suggested.<\/jats:p>","DOI":"10.1002\/med.21874","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T07:30:27Z","timestamp":1640849427000},"page":"1179-1201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["\u03b23\u2010Adrenoceptor, a novel player in the round\u2010trip from neonatal diseases to cancer: Suggestive clues from embryo"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-9147","authenticated-orcid":false,"given":"Luca","family":"Filippi","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neonatology and Neonatal Intensive Care Unit University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cammalleri","sequence":"additional","affiliation":[{"name":"Department of Biology, Unit of General Physiology University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bagnoli","sequence":"additional","affiliation":[{"name":"Department of Biology, Unit of General Physiology University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Dal Monte","sequence":"additional","affiliation":[{"name":"Department of Biology, Unit of General Physiology University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-10-83"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5536"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21336"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0828-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15263"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2014.06.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122584"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134892"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0030-x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0641"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00395-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404710"},{"issue":"21","key":"e_1_2_11_16_1","first-page":"02352","article-title":"Infantile hemangioma. 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