{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:21:27Z","timestamp":1790738487794,"version":"4.1.0"},"reference-count":324,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Besides the well\u2010recognized risk factors, novel conditions increasing cardiovascular morbidity and mortality are emerging. Undesirable emotions and behavior such as anxiety and depression, appear to participate in worsening cardiovascular pathologies. On the other hand, deteriorating conditions of the heart and vasculature result in disturbed mental and emotional health. The pathophysiological background of this bidirectional interplay could reside in an inappropriate activation of vegetative neurohormonal and other humoral systems in both cardiovascular and psychological disturbances. This results in circulus vitiosus potentiating mental and circulatory disorders. Thus, it appears to be of utmost importance to examine the alteration of emotions, cognition, and behavior in cardiovascular patients. In terms of this consideration, recognizing the potential of principal cardiovascular drugs to interact with the mental state in patients with heart or vasculature disturbances is unavoidable, to optimize their therapeutic benefit. In general, beta\u2010blockers, central sympatholytics, ACE inhibitors, ARBs, aldosterone receptor blockers, sacubitril\/valsartan, and fibrates are considered to exert anxiolytic effect in animal experiments and clinical settings. Statins and some beta\u2010blockers appear to have an equivocal impact on mood and anxiety and ivabradine expressed neutral psychological impact. It seems reasonable to suppose that the knowledge of a patient's mood, cognition, and behavior, along with applying careful consideration of the choice of the particular cardiovascular drug and respecting its potential psychological benefit or harm might improve the individualized approach to the treatment of cardiovascular disorders.<\/jats:p>","DOI":"10.1002\/med.21875","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T06:15:49Z","timestamp":1641536149000},"page":"1202-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cardiovascular therapeutics: A new potential for anxiety treatment?"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7235-1710","authenticated-orcid":false,"given":"Kristina","family":"Repova","sequence":"first","affiliation":[{"name":"Institute of Pathophysiology, Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Aziriova","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology, Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Krajcirovicova","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology, Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9922-4885","authenticated-orcid":false,"given":"Fedor","family":"Simko","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology, Faculty of Medicine Comenius University Bratislava Slovakia"},{"name":"3rd Department of Internal Medicine, Faculty of Medicine Comenius University Bratislava Slovakia"},{"name":"Institute of Experimental Endocrinology, Biomedical Research Center Slovak Academy of Sciences Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32858-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.05.041"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00064.2018"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12634"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666151208113006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2016.09.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1410.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2190\/5LX9-D3BH-FUA3-PQF0"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-014-0198-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00237-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000240779.55022.ff"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.10.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.10.008"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371005500107"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-195103000-00002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317703827"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2281-16.2017"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2016.09.007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.07.004"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(87)90017-6"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-042"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.005"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2005.1.4.291"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-019-0972-5"},{"issue":"1","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/jebm.12224","article-title":"The prevalence of impaired glucose regulation in anxiety disorder patients and the relationship with hypothalamic\u2010pituitary\u2010adrenal axis and hypothalamic\u2010pituitary\u2010thyroid axis activity","volume":"12","author":"Zhou Y","year":"2019","journal-title":"J Evid Based Med"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(99)00016-X"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90184-4"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2018.04.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3383"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.07.028"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19318"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.08.040"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01990401"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.2.7944"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01282-2"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.3\/mbourin"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.2\/wcarlezon"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20561"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqv054"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bs.3830190102"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb02946.x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-13-2-329"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08922"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.49.030187.002213"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.10.001"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp073"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.02.002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000156474"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2016_25"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3674-16.2017"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4179(97)90021-4"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(88)90150-7"},{"issue":"3","key":"e_1_2_12_55_1","first-page":"235","article-title":"Examination of the influence of 3,5\u2010DHPG on behavioral activity of angiotensin II","volume":"53","author":"Ho\u0142y Z","year":"2001","journal-title":"Pol J Pharmacol"},{"issue":"2","key":"e_1_2_12_56_1","first-page":"271","article-title":"Effects of angiotensin II and its receptor antagonists on motor activity and anxiety in rats","volume":"54","author":"Braszko JJ","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2012.10.005"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2016_36"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001777"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.042"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000662"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.067"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04440-2"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11181-9"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605233342101"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.09.012"},{"key":"e_1_2_12_67_1","volume-title":"The ESC Textbook of Preventive Cardiology","author":"Sutter JD","year":"2017"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)91863-0"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019643"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199112000-00003"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318236bfa6"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118186"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345910700091401"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198103000-00005"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27441"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.05.006"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.01.009"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2017.0073"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.01.005"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0857-z"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2020.1733248"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018331"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usaa170"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2271"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134892"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0450-11.2011"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115612236"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agw082"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2020.18.2.219"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-020-01518-7"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/2470547020979780"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2021.03.045"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2020-002594"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102162"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14378"},{"issue":"5","key":"e_1_2_12_96_1","first-page":"529","article-title":"Animal model of anxiety: the effect of methyldopa in the genetically hypertensive non\u2010obese rats of Koletsky type and in the rats of Wistar strain","volume":"33","author":"Golda V","year":"1990","journal-title":"Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.11.044"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0024-x"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780360094011"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/1089253218768537"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2012.0119"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2016.0132"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212286"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.06.021"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2019011"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00036-2"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9076042"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00697J"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.1.110"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1515\/JBCPP.2003.14.4.323"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.03.001"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00744-x"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154860"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300921"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0450-5"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.225"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.03.041"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00916.x"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00318"},{"issue":"1","key":"e_1_2_12_120_1","first-page":"59","article-title":"Protective effect of Irbesartan an Angiotensin (AT1) receptor antagonist in unpredictable chronic mild stress induced depression in mice","volume":"67","author":"Ayyub M","year":"2017","journal-title":"Drug Res"},{"key":"e_1_2_12_121_1","first-page":"271678X21100349","article-title":"Telmisartan prevents high\u2010fat diet\u2010induced neurovascular impairments and reduces anxiety\u2010like behavior","volume":"17","author":"Huber G","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.10.004"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07316"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0255-9"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160116"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.07.024"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00433.2013"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.11.006"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.12.026"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.026"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2017.1296949"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283637de2"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.048"},{"issue":"4","key":"e_1_2_12_134_1","first-page":"147","article-title":"Effect of single treatment with the antihypertensive drug eplerenone on hormone levels and anxiety\u2010like behaviour in rats","volume":"42","author":"Hlavacova N","year":"2008","journal-title":"Endocr Regul"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0138"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12607"},{"key":"e_1_2_12_137_1","first-page":"1","article-title":"Impact of sacubitril\/valsartan treatment on depression and anxiety in heart failure with reduced ejection fraction","volume":"18","author":"Dereli S","year":"2020","journal-title":"Acta Cardiol"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00758-x"},{"issue":"1","key":"e_1_2_12_139_1","first-page":"39","article-title":"Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats","volume":"17","author":"Kilic FS","year":"2012","journal-title":"Neurosciences"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202189"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3425-6"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12686"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250079"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.09.019"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510853"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730030-00003"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40800-015-0024-2"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch035"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92591-G"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.003"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30311-4"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147343"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.045"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.02.003"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.02.006"},{"issue":"6","key":"e_1_2_12_156_1","first-page":"895","article-title":"Effect of ivabradine, captopril and melatonin on the behaviour of rats in L\u2010nitro\u2010arginine methyl ester\u2010induced hypertension","volume":"67","author":"Aziriova S","year":"2016","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934048"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355169"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-014-0147-3"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343631"},{"issue":"1","key":"e_1_2_12_161_1","first-page":"127","article-title":"Experimental research on the effect of calcium channel blockers nifedipine and verapamil on the anxiety in mice","volume":"34","author":"Fulga IG","year":"1997","journal-title":"Rom J Physiol"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201092"},{"issue":"2","key":"e_1_2_12_163_1","first-page":"119","article-title":"Inefficacy of single\u2010dose nifedipine in the treatment of phobic anxiety","volume":"27","author":"Klein E","year":"1990","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035417"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13486"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05654"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.02.014"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198005040-00004"},{"key":"e_1_2_12_169_1","first-page":"CD003893","article-title":"Methyldopa for primary hypertension","volume":"4","author":"Mah GT","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198000021-00007"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631040-00003"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488411798375886"},{"key":"e_1_2_12_173_1","first-page":"CD007990","article-title":"Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders","volume":"6","author":"Osland ST","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1706480"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0916-3"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867417721654"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666141112160013"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932592"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081612"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.092"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000388489.28213.08"},{"issue":"1","key":"e_1_2_12_182_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.33549\/physiolres.930000.49.37","article-title":"The potential role of nitric oxide in the hypertrophic growth of the left ventricle","volume":"49","author":"Simko F","year":"2000","journal-title":"Physiol Res"},{"issue":"1","key":"e_1_2_12_183_1","first-page":"1","article-title":"Heart failure and angiotensin converting enzyme inhibition: problems and perspectives","volume":"48","author":"Simko F","year":"1999","journal-title":"Physiol Res"},{"key":"e_1_2_12_184_1","first-page":"703175","article-title":"Hypertension and cardiovascular remodelling in rats exposed to continuous light: protection by ACE\u2013inhibition and melatonin","author":"Simko F","year":"2014","journal-title":"Mediators of Inflamm"},{"issue":"6","key":"e_1_2_12_185_1","first-page":"466","article-title":"Effect of angiotensin\u2010converting enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPP) randomized trial. The Captopril Prevention Project (CAPP) Study Group","volume":"1","author":"CAPP Study Group","year":"1999","journal-title":"Curr Hypertens Rep"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.713"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271001"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512213332503"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706043162301"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250502"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271003"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69201-5"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.06.017"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.08.005"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/351758"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2016"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.03.728"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0859-x"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026215712983"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08089-3"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14282-1"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000231394.79609.24"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08188"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320313516173"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.05.006"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071098"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210182"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200922"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018120-00019"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01847"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00075.2012"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.196782"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01012.2013"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112947"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/169795a0"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.09.008"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb41221.x"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000084"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000259805.18468.8c"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2016.1246564"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90399.2008"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.02.004"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093956"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1226"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2723"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1763"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.250"},{"issue":"4","key":"e_1_2_12_232_1","first-page":"273","article-title":"Inhibition of neprilysin \u2013 new horizon in heart failure therapy","volume":"25","author":"Simko F","year":"2016","journal-title":"Cardiol\u00a0Lett"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.056"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2540531"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013748"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft052"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.799"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1342"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.119.119370"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2016.08.002"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200219091102"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0820-9"},{"issue":"1","key":"e_1_2_12_243_1","first-page":"5","article-title":"Effects of natriuretic peptides upon hypothalamo\u2010pituitary\u2010adrenocortical system activity and anxiety behaviour","volume":"108","author":"Wiedemann K","year":"2000","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.08.003"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2019.101993"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0163-1"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.2.138"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200518"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2013.783049"},{"key":"e_1_2_12_250_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803174105"},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55947-5"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527319666200715102430"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.005"},{"key":"e_1_2_12_254_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.130300"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31942-1"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308537"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01837.x"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000358830.95439.e8"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.07.032"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12461"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi100276b"},{"key":"e_1_2_12_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.02.006"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(00)00024-8"},{"key":"e_1_2_12_264_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-017-0144-4"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.01.056"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.019562"},{"key":"e_1_2_12_267_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.035"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2011.06.002"},{"key":"e_1_2_12_269_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R400004-JLR200"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90285-8"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199111000-00005"},{"key":"e_1_2_12_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.02.012"},{"key":"e_1_2_12_273_1","doi-asserted-by":"publisher","DOI":"10.1192\/S000712500029171X"},{"key":"e_1_2_12_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90683-4"},{"key":"e_1_2_12_275_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1985.tb01279.x"},{"key":"e_1_2_12_276_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.025817"},{"key":"e_1_2_12_277_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00305"},{"key":"e_1_2_12_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61198-1"},{"key":"e_1_2_12_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2019.109253"},{"key":"e_1_2_12_280_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13075"},{"key":"e_1_2_12_281_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0567-2"},{"key":"e_1_2_12_282_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103017"},{"key":"e_1_2_12_283_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14020"},{"key":"e_1_2_12_284_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.607998"},{"key":"e_1_2_12_285_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-016-0178-z"},{"key":"e_1_2_12_286_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12620"},{"key":"e_1_2_12_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.096"},{"key":"e_1_2_12_288_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_2_12_289_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"e_1_2_12_290_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000041"},{"key":"e_1_2_12_291_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_12_292_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00188-0"},{"key":"e_1_2_12_293_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03252-9"},{"key":"e_1_2_12_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.017"},{"key":"e_1_2_12_295_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.019"},{"key":"e_1_2_12_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.006"},{"key":"e_1_2_12_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.025"},{"key":"e_1_2_12_298_1","unstructured":"Defibrillators| NHLBI NIH."},{"key":"e_1_2_12_299_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.07.015"},{"key":"e_1_2_12_300_1","doi-asserted-by":"publisher","DOI":"10.1053\/eupc.2002.0258"},{"key":"e_1_2_12_301_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.01113.x"},{"key":"e_1_2_12_302_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960220709"},{"key":"e_1_2_12_303_1","doi-asserted-by":"publisher","DOI":"10.1348\/135910703321649141"},{"key":"e_1_2_12_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2020.07.008"},{"key":"e_1_2_12_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.05.007"},{"key":"e_1_2_12_306_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612263352601"},{"key":"e_1_2_12_307_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00773.x"},{"key":"e_1_2_12_308_1","doi-asserted-by":"publisher","DOI":"10.1348\/1359107041557039"},{"key":"e_1_2_12_309_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1724227"},{"issue":"1","key":"e_1_2_12_310_1","first-page":"11","article-title":"The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: preliminary communication","volume":"19","author":"Korosi B","year":"2017","journal-title":"Neuropsychopharmacol Hung"},{"key":"e_1_2_12_311_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.65.5.2056244"},{"key":"e_1_2_12_312_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218038"},{"key":"e_1_2_12_313_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.04178.x"},{"key":"e_1_2_12_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00609-1"},{"key":"e_1_2_12_315_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1814141"},{"key":"e_1_2_12_316_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-020-0387-4"},{"key":"e_1_2_12_317_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15047"},{"key":"e_1_2_12_318_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106116"},{"key":"e_1_2_12_319_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/131115"},{"key":"e_1_2_12_320_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9050510"},{"key":"e_1_2_12_321_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.42"},{"key":"e_1_2_12_322_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40596-021-01444-9"},{"key":"e_1_2_12_323_1","doi-asserted-by":"publisher","DOI":"10.3390\/bs11050061"},{"key":"e_1_2_12_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.07.037"},{"key":"e_1_2_12_325_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/703175"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/med.21875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:06:36Z","timestamp":1726434396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":324,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/med.21875"],"URL":"https:\/\/doi.org\/10.1002\/med.21875","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"2020-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}