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Moreover, over the past several decades, the frequency of all skin cancers has increased much more dynamically than that of almost any other type of cancer. Among the available therapeutic options for skin cancers, chemotherapy used immediately after the surgical intervention has been an essential element. Unfortunately, the main problem with conventional chemopreventive regimens involves the lack of response to treatment and the associated side effects. Hence, there is a need for much more effective anticancer drugs. Correspondingly, the targeted alternatives have involved phytochemicals, which are safer chemotherapeutic agents and exhibit competitive anticancer activity with high therapeutic efficacy. Among polyphenolic compounds, some flavonoids and their derivatives, which are mostly found in medicinal plants, have been demonstrated to influence the modulation of signaling pathways at each stage of the carcinogenesis process, which is also important in the context of skin cancers. Hence, this review focuses on an exhaustive overview of the therapeutic effects of luteolin and its derivatives in the treatment and prevention of skin cancers. The bioavailability and structure\u2013activity relationships of luteolin derivatives are also discussed. This review is the first such complete account of all of the scientific reports concerning this particular group of natural compounds that target a specific area of neoplastic diseases.<\/jats:p>","DOI":"10.1002\/med.21880","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:53:48Z","timestamp":1645433628000},"page":"1423-1462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-9869","authenticated-orcid":false,"given":"Aleksandra M.","family":"Juszczak","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine Medical University of Bia\u0142ystok Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-560X","authenticated-orcid":false,"given":"Ute","family":"W\u00f6elfle","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Research Center Skinitial, Medical Center, Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-6667","authenticated-orcid":false,"given":"Marijana Zovko","family":"Kon\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-1048","authenticated-orcid":false,"given":"Micha\u0142","family":"Tomczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy with the 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