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At present, there is no cure for PD, and currently available therapeutics are insufficient to meet patient needs. Ferroptosis, a distinctive iron\u2010dependent cell death mode characterized by lipid peroxidation and oxidative stress, has pathophysiological features similar to those of PD, including iron accumulation, reactive oxygen species\u2010induced oxidative damage, and mitochondrial dysfunction. Ferroptosis has been identified as a specific pathway of neuronal death and is closely related to the pathogenesis of PD. Despite the similarities in the biological targets involved in PD pathogenesis and ferroptosis, the relationship between novel targets in PD and ferroptosis has been neglected in the literature. In this review, the mechanism of ferroptosis is discussed, and the potential therapeutic targets implicated in both PD and ferroptosis are compared. Furthermore, the anti\u2010PD effects of several ferroptosis inhibitors, as well as clinical studies thereof, and the identification of novel lead compounds for the treatment of PD and the inhibition of ferroptosis are reviewed. It is hoped that this review can promote research to further elucidate the relationship between ferroptosis and PD and provide new strategies for the development of novel ferroptosis\u2010targeting PD therapy.<\/jats:p>","DOI":"10.1002\/med.21939","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T11:14:37Z","timestamp":1678965277000},"page":"872-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis"],"prefix":"10.1002","volume":"43","author":[{"given":"Xiaoying","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy Hangzhou Normal University  Hangzhou People's Republic of China"},{"name":"Key Laboratory of Elemene Class Anti\u2010Cancer Chinese Medicines, Engineering Laboratory of Development and 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