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Identification of new antimicrobial targets is critical to avoid possible cross\u2010resistance issues. Bacterial proton motive force (PMF), an energetic pathway located on the bacterial membrane, crucially regulates various biological possesses such as adenosine triphosphate\u00a0synthesis, active transport of molecules, and rotation of bacterial flagella. Nevertheless, the potential of bacterial PMF as an antibacterial target remains largely unexplored. The PMF generally comprises electric potential (\u0394\u03a8) and transmembrane proton gradient (\u0394pH). In this review, we present an overview of bacterial PMF, including its functions and characterizations, highlighting the representative antimicrobial agents that specifically target either \u0394\u03a8 or \u0394pH. At the same time, we also discuss the adjuvant potential of bacterial PMF\u2010targeting compounds. 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