{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:04Z","timestamp":1786978264247,"version":"build-2736575974"},"reference-count":299,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 992\u20102021"],"award-info":[{"award-number":["ALTF 992\u20102021"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["779295"],"award-info":[{"award-number":["779295"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0808.18N"],"award-info":[{"award-number":["G.0808.18N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0F7519N"],"award-info":[{"award-number":["G0F7519N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0F8822N"],"award-info":[{"award-number":["G0F8822N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["G0F7519N"],"award-info":[{"award-number":["G0F7519N"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["G0F8822N"],"award-info":[{"award-number":["G0F8822N"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C16\/17\/010"],"award-info":[{"award-number":["C16\/17\/010"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophils are powerful effector cells leading the first wave of acute host\u2010protective responses. These innate leukocytes are endowed with oxidative and nonoxidative defence mechanisms, and play well\u2010established roles in fighting invading pathogens. With microbicidal weaponry largely devoid of specificity and an all\u2010too\u2010well recognized toxicity potential, collateral damage may occur in neutrophil\u2010rich diseases. However, emerging evidence suggests that neutrophils are more versatile, heterogeneous, and sophisticated cells than initially thought. At the crossroads of innate and adaptive immunity, neutrophils demonstrate their multifaceted functions in infectious and noninfectious pathologies including cancer, autoinflammation, and autoimmune diseases. Here, we discuss the kinetics of neutrophils and their products of activation from bench to bedside during health and disease, and provide an overview of the versatile functions of neutrophils as key modulators of immune responses and physiological processes. We focus specifically on those activities and concepts that have been validated with primary human cells.<\/jats:p>","DOI":"10.1002\/med.21958","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T06:44:50Z","timestamp":1681109090000},"page":"1537-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Fast and furious: The neutrophil and its armamentarium in health and disease"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-0124","authenticated-orcid":false,"given":"Mieke","family":"Metzemaekers","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3527-1145","authenticated-orcid":false,"given":"Bert","family":"Malengier\u2010Devlies","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke","family":"Gouwy","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"De Somer","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"},{"name":"Division of Pediatric Rheumatology University Hospital Leuven  Leuven Belgium"},{"name":"European Reference Network for Rare Immunodeficiency Autoinflammatory and Autoimmune Diseases (RITA) at the University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando de Queiroz","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Sao Paulo  Ribeirao Preto Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain","family":"Opdenakker","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-5545","authenticated-orcid":false,"given":"Paul","family":"Proost","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01243-7"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.1.7"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012073432307"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2731-8"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00373"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01066"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12448"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.058"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.03.004"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.05.003"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2018"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.007"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12440"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02867"},{"key":"e_1_2_20_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.04.013"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2012.2012"},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab2116"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.017"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.082"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.208918"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41649"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12719"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2962"},{"key":"e_1_2_20_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/790174"},{"key":"e_1_2_20_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1226"},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.011"},{"key":"e_1_2_20_30_1","first-page":"1266171","article-title":"Current insights into neutrophil homeostasis","author":"Bugl S","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4162"},{"key":"e_1_2_20_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200933"},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388579"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-535419"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104167"},{"key":"e_1_2_20_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam8929"},{"key":"e_1_2_20_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12967"},{"key":"e_1_2_20_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000471"},{"key":"e_1_2_20_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07505-2"},{"key":"e_1_2_20_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401320"},{"key":"e_1_2_20_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1964"},{"key":"e_1_2_20_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.016"},{"key":"e_1_2_20_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-502435"},{"key":"e_1_2_20_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110647"},{"key":"e_1_2_20_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002225"},{"key":"e_1_2_20_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02099"},{"key":"e_1_2_20_47_1","doi-asserted-by":"publisher","DOI":"10.33594\/000000245"},{"key":"e_1_2_20_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(85)90025-6"},{"key":"e_1_2_20_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00228-8"},{"key":"e_1_2_20_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12437"},{"key":"e_1_2_20_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.640094"},{"key":"e_1_2_20_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00239.2008"},{"key":"e_1_2_20_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1980"},{"key":"e_1_2_20_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.005"},{"key":"e_1_2_20_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.3793"},{"key":"e_1_2_20_56_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1212619"},{"key":"e_1_2_20_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/416291a"},{"key":"e_1_2_20_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12447"},{"key":"e_1_2_20_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10650"},{"key":"e_1_2_20_60_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1204697"},{"key":"e_1_2_20_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900235"},{"key":"e_1_2_20_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12951"},{"key":"e_1_2_20_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwm026"},{"key":"e_1_2_20_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.9.3430"},{"key":"e_1_2_20_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.4034"},{"key":"e_1_2_20_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01884.x"},{"key":"e_1_2_20_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2015.12.003"},{"key":"e_1_2_20_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.05.011"},{"key":"e_1_2_20_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.03.003"},{"key":"e_1_2_20_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06857"},{"key":"e_1_2_20_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.043"},{"key":"e_1_2_20_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.03.006"},{"key":"e_1_2_20_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10230"},{"key":"e_1_2_20_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.13553"},{"key":"e_1_2_20_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02588.x"},{"key":"e_1_2_20_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-864538"},{"key":"e_1_2_20_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.6.1457.1457"},{"key":"e_1_2_20_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)92131-I"},{"key":"e_1_2_20_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9586"},{"key":"e_1_2_20_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(98)00008-2"},{"key":"e_1_2_20_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/332647a0"},{"key":"e_1_2_20_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.624025"},{"key":"e_1_2_20_83_1","first-page":"18964","article-title":"The role of CR3 (CD11b\/CD18) and CR4 (CD11c\/CD18) in complement\u2010mediated phagocytosis and podosome formation by human phagocytes","author":"Luk\u00e1csi S","year":"2017","journal-title":"Immunol Lett"},{"key":"e_1_2_20_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)88244-1"},{"key":"e_1_2_20_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.09.051"},{"key":"e_1_2_20_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01069-2"},{"key":"e_1_2_20_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1407"},{"key":"e_1_2_20_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00305-4"},{"key":"e_1_2_20_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32729"},{"key":"e_1_2_20_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4294"},{"key":"e_1_2_20_91_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_2_20_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2847"},{"key":"e_1_2_20_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015682"},{"key":"e_1_2_20_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.044"},{"key":"e_1_2_20_95_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006052"},{"key":"e_1_2_20_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4027"},{"key":"e_1_2_20_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14252"},{"key":"e_1_2_20_98_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200806072"},{"key":"e_1_2_20_99_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201167"},{"key":"e_1_2_20_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-751636"},{"key":"e_1_2_20_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414055112"},{"key":"e_1_2_20_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18302"},{"key":"e_1_2_20_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6676"},{"key":"e_1_2_20_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011525"},{"key":"e_1_2_20_105_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4604713"},{"key":"e_1_2_20_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-12-844605"},{"key":"e_1_2_20_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0412-0"},{"key":"e_1_2_20_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2774-x"},{"key":"e_1_2_20_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00295-4"},{"key":"e_1_2_20_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62737"},{"key":"e_1_2_20_111_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.17805.x"},{"key":"e_1_2_20_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.140442"},{"key":"e_1_2_20_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.011"},{"key":"e_1_2_20_114_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118888"},{"key":"e_1_2_20_115_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-783027"},{"key":"e_1_2_20_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00483"},{"key":"e_1_2_20_117_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170168"},{"key":"e_1_2_20_118_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141618"},{"key":"e_1_2_20_119_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130664"},{"key":"e_1_2_20_120_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060925"},{"key":"e_1_2_20_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.08.012"},{"key":"e_1_2_20_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-188375"},{"key":"e_1_2_20_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-664995"},{"key":"e_1_2_20_124_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0905496"},{"key":"e_1_2_20_125_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181468"},{"key":"e_1_2_20_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.003"},{"key":"e_1_2_20_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715756115"},{"key":"e_1_2_20_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5227"},{"key":"e_1_2_20_129_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000022"},{"key":"e_1_2_20_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.597595"},{"key":"e_1_2_20_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2194"},{"key":"e_1_2_20_132_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088377"},{"key":"e_1_2_20_133_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1HI0415-149R"},{"key":"e_1_2_20_134_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.8.1357"},{"key":"e_1_2_20_135_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.639"},{"key":"e_1_2_20_136_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119468"},{"key":"e_1_2_20_137_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071765"},{"key":"e_1_2_20_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.017"},{"key":"e_1_2_20_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.08.003"},{"key":"e_1_2_20_140_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-453217"},{"key":"e_1_2_20_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2779"},{"key":"e_1_2_20_142_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.8.2673"},{"key":"e_1_2_20_143_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35740"},{"key":"e_1_2_20_144_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348676"},{"key":"e_1_2_20_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-1008-0"},{"key":"e_1_2_20_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.02.003"},{"key":"e_1_2_20_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2012.02.007"},{"key":"e_1_2_20_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00272"},{"key":"e_1_2_20_149_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.2.301"},{"key":"e_1_2_20_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1864"},{"issue":"1","key":"e_1_2_20_151_1","first-page":"20","article-title":"Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin","volume":"119","author":"Bournazou I","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_20_152_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-129080"},{"key":"e_1_2_20_153_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111908"},{"key":"e_1_2_20_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6917-6923.2000"},{"key":"e_1_2_20_155_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-287243"},{"key":"e_1_2_20_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq434"},{"key":"e_1_2_20_157_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102002"},{"key":"e_1_2_20_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv030"},{"key":"e_1_2_20_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit574"},{"key":"e_1_2_20_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.11.010"},{"key":"e_1_2_20_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13005"},{"key":"e_1_2_20_162_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57990"},{"key":"e_1_2_20_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.07.006"},{"key":"e_1_2_20_164_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180382"},{"key":"e_1_2_20_165_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019031609"},{"key":"e_1_2_20_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948394"},{"key":"e_1_2_20_167_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4MR0217-048RR"},{"key":"e_1_2_20_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200107)31:7<1981::AID-IMMU1981>3.0.CO;2-X"},{"key":"e_1_2_20_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.07.004"},{"key":"e_1_2_20_170_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.1.9"},{"key":"e_1_2_20_171_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041276"},{"key":"e_1_2_20_172_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0905526"},{"key":"e_1_2_20_173_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.1.225.225"},{"key":"e_1_2_20_174_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103414"},{"key":"e_1_2_20_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02471.x"},{"key":"e_1_2_20_176_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905054116"},{"key":"e_1_2_20_177_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-744441"},{"key":"e_1_2_20_178_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-063826"},{"issue":"8","key":"e_1_2_20_179_1","first-page":"2887","article-title":"APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa","volume":"118","author":"Huard B","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_20_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.11.009"},{"key":"e_1_2_20_181_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161621"},{"key":"e_1_2_20_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3583"},{"key":"e_1_2_20_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2830"},{"key":"e_1_2_20_184_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40060654.x"},{"key":"e_1_2_20_185_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0811417"},{"key":"e_1_2_20_186_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1061224"},{"key":"e_1_2_20_187_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002102"},{"key":"e_1_2_20_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2780-z"},{"key":"e_1_2_20_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI0917-361R"},{"key":"e_1_2_20_190_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.397"},{"key":"e_1_2_20_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.005"},{"key":"e_1_2_20_192_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.10.3938.bloodjournal86103938"},{"key":"e_1_2_20_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43568"},{"key":"e_1_2_20_194_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-713206"},{"key":"e_1_2_20_195_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801255"},{"key":"e_1_2_20_196_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017015578"},{"key":"e_1_2_20_197_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139163"},{"key":"e_1_2_20_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1271"},{"issue":"1","key":"e_1_2_20_199_1","first-page":"1","article-title":"New insights into the mechanisms of nuclear segmentation in human neutrophils","volume":"73","author":"Sanchez JA","year":"1999","journal-title":"JCB"},{"key":"e_1_2_20_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.01.002"},{"key":"e_1_2_20_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.04.016"},{"key":"e_1_2_20_202_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.1.91"},{"key":"e_1_2_20_203_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-718999"},{"key":"e_1_2_20_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291105"},{"key":"e_1_2_20_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.039"},{"key":"e_1_2_20_206_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1921"},{"key":"e_1_2_20_207_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100450"},{"key":"e_1_2_20_208_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844563"},{"key":"e_1_2_20_209_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.43"},{"key":"e_1_2_20_210_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu1154"},{"key":"e_1_2_20_211_1","doi-asserted-by":"publisher","DOI":"10.1159\/000041062"},{"key":"e_1_2_20_212_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0712349"},{"key":"e_1_2_20_213_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106114"},{"key":"e_1_2_20_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.10.001"},{"key":"e_1_2_20_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.12.008"},{"key":"e_1_2_20_216_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007696"},{"key":"e_1_2_20_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0094-4"},{"key":"e_1_2_20_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.32"},{"key":"e_1_2_20_219_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000696"},{"key":"e_1_2_20_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.03.034"},{"key":"e_1_2_20_221_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-450551"},{"key":"e_1_2_20_222_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12301"},{"key":"e_1_2_20_223_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312461060"},{"issue":"11","key":"e_1_2_20_224_1","first-page":"2162","article-title":"Intracellular oxidative activation in synovial fluid neutrophils from patients with rheumatoid arthritis but not from other arthritis patients","volume":"34","author":"Cedergren J","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_20_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.02.013"},{"key":"e_1_2_20_226_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310392421"},{"key":"e_1_2_20_227_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0688com"},{"key":"e_1_2_20_228_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01084.x"},{"key":"e_1_2_20_229_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag3358"},{"key":"e_1_2_20_230_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001201"},{"key":"e_1_2_20_231_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key067"},{"key":"e_1_2_20_232_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909927107"},{"key":"e_1_2_20_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20125"},{"key":"e_1_2_20_234_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310377089"},{"key":"e_1_2_20_235_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1429-3"},{"key":"e_1_2_20_236_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu299"},{"issue":"4","key":"e_1_2_20_237_1","first-page":"317","article-title":"Cytokine\u2010mediated regulation of human leukocyte gelatinases and role in arthritis","volume":"10","author":"Opdenakker G","year":"1991","journal-title":"Lymphokine Cytokine Res"},{"key":"e_1_2_20_238_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa794"},{"key":"e_1_2_20_239_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.205047"},{"key":"e_1_2_20_240_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2048"},{"key":"e_1_2_20_241_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41605"},{"key":"e_1_2_20_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26163-4"},{"key":"e_1_2_20_243_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801512"},{"key":"e_1_2_20_244_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515586084"},{"key":"e_1_2_20_245_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304475"},{"key":"e_1_2_20_246_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4579"},{"key":"e_1_2_20_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37852-5"},{"key":"e_1_2_20_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80721-7"},{"key":"e_1_2_20_249_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112227"},{"key":"e_1_2_20_250_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205958"},{"key":"e_1_2_20_251_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00716"},{"issue":"6","key":"e_1_2_20_252_1","first-page":"113","article-title":"Increased serum concentrations of neutrophil\u2010derived protein S100A12 in heterozygous carriers of MEFV mutations","volume":"33","author":"Lieber M","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_20_253_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf1471"},{"key":"e_1_2_20_254_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01008-4"},{"key":"e_1_2_20_255_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446615"},{"key":"e_1_2_20_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21657"},{"key":"e_1_2_20_257_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep327"},{"key":"e_1_2_20_258_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38134"},{"key":"e_1_2_20_259_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40442"},{"key":"e_1_2_20_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62527-8"},{"key":"e_1_2_20_261_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37223"},{"key":"e_1_2_20_262_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02155"},{"key":"e_1_2_20_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.013"},{"key":"e_1_2_20_264_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gep053"},{"key":"e_1_2_20_265_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706438104"},{"key":"e_1_2_20_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2017.11.006"},{"key":"e_1_2_20_267_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.770819"},{"key":"e_1_2_20_268_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2084"},{"key":"e_1_2_20_269_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-010389"},{"key":"e_1_2_20_270_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1711"},{"key":"e_1_2_20_271_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0915-y"},{"key":"e_1_2_20_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.001"},{"key":"e_1_2_20_273_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77053"},{"key":"e_1_2_20_274_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30076"},{"key":"e_1_2_20_275_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064814"},{"key":"e_1_2_20_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.082"},{"key":"e_1_2_20_277_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12453"},{"key":"e_1_2_20_278_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400680"},{"key":"e_1_2_20_279_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1112"},{"key":"e_1_2_20_280_1","doi-asserted-by":"publisher","DOI":"10.1038\/343170a0"},{"key":"e_1_2_20_281_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116019"},{"key":"e_1_2_20_282_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.11.6250"},{"key":"e_1_2_20_283_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2313"},{"key":"e_1_2_20_284_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103551"},{"key":"e_1_2_20_285_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13392"},{"key":"e_1_2_20_286_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.5999"},{"key":"e_1_2_20_287_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1392"},{"key":"e_1_2_20_288_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3547"},{"key":"e_1_2_20_289_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-423525"},{"key":"e_1_2_20_290_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140533"},{"key":"e_1_2_20_291_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1999.0468"},{"key":"e_1_2_20_292_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804187"},{"key":"e_1_2_20_293_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601767"},{"key":"e_1_2_20_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.05.001"},{"key":"e_1_2_20_295_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7684"},{"key":"e_1_2_20_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.01.010"},{"key":"e_1_2_20_297_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0391-5"},{"key":"e_1_2_20_298_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24623"},{"key":"e_1_2_20_299_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.008"},{"key":"e_1_2_20_300_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111305"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:09:51Z","timestamp":1692234591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":299,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/med.21958"],"URL":"https:\/\/doi.org\/10.1002\/med.21958","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]},"assertion":[{"value":"2022-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}