{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:20:36Z","timestamp":1783938036652,"version":"3.55.0"},"reference-count":250,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic condition that primarily affects the synovial joints and adjacent tissues, including bone, muscle, and tendons. The World Health Organization recognizes RA as one of the most prevalent chronic inflammatory diseases. In the last decade, there was an expansion on the available RA therapeutic options which aimed to improve patient's quality of life. Despite the extensive research and the emergence of new therapeutic approaches and drugs, there are still significant unwanted side effects associated to these drugs and still a vast number of patients that do not respond positively to the existing therapeutic strategies. Over the years, several references to the use of flavonoids in the quest for new treatments for RA have emerged. This review aimed to summarize the existing literature about the flavonoids' effects on the major pathogenic\/molecular targets of RA and their potential use as lead compounds for the development of new effective molecules for RA treatment. It is demonstrated that flavonoids can modulate various players in synovial inflammation, regulate immune cell function, decrease synoviocytes proliferation and balance the apoptotic process, decrease angiogenesis, and stop\/prevent bone and cartilage degradation, which are all dominant features of RA. Although further investigation is necessary to determine the effectiveness of flavonoids in humans, the available data from in vitro and in vivo models suggest their potential as new disease\u2010modifying anti\u2010rheumatic drugs. This review highlights the use of flavonoids as a promising avenue for future research in the treatment of RA.<\/jats:p>","DOI":"10.1002\/med.21990","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:18:47Z","timestamp":1692695927000},"page":"497-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rheumatoid arthritis molecular targets and their importance to flavonoid\u2010based therapy"],"prefix":"10.1002","volume":"44","author":[{"given":"Ana T.","family":"Rufino","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-9967","authenticated-orcid":false,"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-6526","authenticated-orcid":false,"given":"Carina","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M. P.","family":"Ferreira de Oliveira","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-7934","authenticated-orcid":false,"given":"Daniela","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto Porto Portugal"},{"name":"Faculty of Agrarian Sciences and Environment University of the Azores  A\u00e7ores Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.12.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.08.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar578"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00570"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-12"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204627"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23177"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2951"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530317666171114122417"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24596"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31491-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39480"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201920190105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162750"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1924613"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1246413"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2020.06.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100161"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar86"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235856"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2050"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2412"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707449"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.02.023"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.04.008"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2016.12.001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0517-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar551"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.9.1029"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2011.22067"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.12.013"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152518"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9365-x"},{"issue":"2","key":"e_1_2_7_42_1","first-page":"60ii","article-title":"Angiogenesis as a target in rheumatoid arthritis","volume":"62","author":"Koch AE","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.04.005"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.04.020"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24844"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27650"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39563"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080818"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2110"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061775"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2009::AID-ART349>3.0.CO;2-L"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1220393"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666161104130026"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21347"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0559-8"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.10.806"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9995-x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.11.030"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.06.019"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180214121734"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666151111143616"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029615595879"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X1100910X"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1368503"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.11.039"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO00722A"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1558221"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0217-4"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.10.015"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21740"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.04.052"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(03)00259-0"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000470"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0619-z"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040880"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1360280"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.01755.x"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.05.024"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12717"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1356-3"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.07.016"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9725-9"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4026688"},{"key":"e_1_2_7_87_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/268065","article-title":"Baicalin inhibits IL\u201017\u2010mediated joint inflammation in murine adjuvant\u2010induced arthritis","volume":"2013","author":"Yang X","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02848793"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.05.018"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.114917"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12970"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515604620"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2830-y"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2509"},{"issue":"3","key":"e_1_2_7_95_1","first-page":"161","article-title":"Comparison of the effects of genistein and daidzein with dexamethasone and soy protein on rheumatoid arthritis in rats","volume":"1","author":"Mohammad\u2010Shahi M","year":"2011","journal-title":"BioImpacts: BI"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106387"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.06.029"},{"key":"e_1_2_7_98_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9806160","article-title":"Apoptosis effects of dihydrokaempferol isolated from Bauhinia championii on synoviocytes","volume":"2018","author":"Zhang Y","year":"2018","journal-title":"Evid Based Complement Alter Med"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6596"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0514-261RR"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215624020"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39447"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-015-0097-9"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127165"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802675105"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.05.016"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.11082FP"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23937"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23594"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0597-5"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22023"},{"issue":"9","key":"e_1_2_7_112_1","first-page":"14628","article-title":"Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast\u2010like synoviocytes through Akt\/FOXO1 signaling","volume":"120","author":"Liu Y","year":"2019","journal-title":"JCB"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.10.001"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.11.005"},{"issue":"4","key":"e_1_2_7_115_1","first-page":"3619","article-title":"Galangin protects human rheumatoid arthritis fibroblast\u2011like synoviocytes via suppression of the NF\u2011\u03baB\/NLRP3 pathway","volume":"18","author":"Fu Q","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.04.014"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2062969"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.07.007"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161025150403"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S52354"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1463-z"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.140"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20110212"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.04.003"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200102)44:2<260::AID-ANR42>3.0.CO;2-P"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106384"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153036"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27924"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.723010"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.07.001"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3209"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.05.006"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.04.002"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.5606\/ArchRheumatol.2018.6519"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439538"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.07.020"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2430-4"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.2.0011"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916254"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2906"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3708"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0433-0"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.12.011"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.03.044"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1468"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0810-0"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2015.1095763"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2008.10.005"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.06.029"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.06.010"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800202"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2017.03.009"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21282"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.02.007"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2015.1096942"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.04.010"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.05.026"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.07.016"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010279"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2011.564186"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172939"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01311F"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.05.171"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520300305"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00499"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2020.1742732"},{"issue":"4","key":"e_1_2_7_167_1","first-page":"2792","article-title":"Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis","volume":"121","author":"Saccol RSP","year":"2020","journal-title":"JCB"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3413"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108622"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190206225034"},{"key":"e_1_2_7_171_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4259"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0464-2"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.057"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.013"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.026"},{"key":"e_1_2_7_176_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2755"},{"key":"e_1_2_7_177_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2016.1140093"},{"key":"e_1_2_7_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.08.008"},{"key":"e_1_2_7_179_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2008.1246"},{"key":"e_1_2_7_180_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10719762"},{"key":"e_1_2_7_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-006-0067-z"},{"issue":"9","key":"e_1_2_7_182_1","first-page":"1680","article-title":"Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein\u20101 expression by tumor necrosis factor\u2010alpha in cultured human synovial cells","volume":"24","author":"Sato M","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00432-5"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112841"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.04.017"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.1159\/000451027"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.05.010"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21674-6"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501163"},{"key":"e_1_2_7_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2501::AID-ANR18>3.0.CO;2-K"},{"key":"e_1_2_7_191_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar300"},{"issue":"5","key":"e_1_2_7_192_1","first-page":"827","article-title":"High DNA\u2010binding activity of transcription factor NF\u2010kappa B in synovial membranes of patients with rheumatoid arthritis","volume":"37","author":"Asahara H","year":"1995","journal-title":"Biochem Mol Biol Int"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390407"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939808995367"},{"key":"e_1_2_7_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.64"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq455"},{"key":"e_1_2_7_197_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-016-0581-0"},{"key":"e_1_2_7_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.021"},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0775-4"},{"key":"e_1_2_7_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04699-8"},{"key":"e_1_2_7_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260404"},{"key":"e_1_2_7_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.190"},{"key":"e_1_2_7_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.60"},{"key":"e_1_2_7_204_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00702"},{"key":"e_1_2_7_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00046-0"},{"key":"e_1_2_7_206_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118202"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13317-020-00145-x"},{"issue":"8","key":"e_1_2_7_208_1","first-page":"1345","article-title":"Ultrastructural demonstration of apoptosis, Fas and Bcl\u20102 expression of rheumatoid synovial fibroblasts","volume":"23","author":"Matsumoto S","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_7_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-009-0317-y"},{"issue":"6","key":"e_1_2_7_210_1","first-page":"2143","article-title":"Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium","volume":"149","author":"Firestein GS","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_7_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-017-0073-3"},{"key":"e_1_2_7_212_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep358"},{"key":"e_1_2_7_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20764"},{"key":"e_1_2_7_214_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152511796196498"},{"issue":"3","key":"e_1_2_7_215_1","first-page":"235","article-title":"Structure, antioxidative and anticancer properties of flavonoids","volume":"58","author":"Czaplinska M","year":"2012","journal-title":"Postepy Biochem"},{"key":"e_1_2_7_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0341-y"},{"key":"e_1_2_7_217_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010920"},{"key":"e_1_2_7_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00079-2"},{"key":"e_1_2_7_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.12.002"},{"key":"e_1_2_7_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22454-z"},{"key":"e_1_2_7_221_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2130"},{"key":"e_1_2_7_222_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.11.792"},{"key":"e_1_2_7_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49853-0"},{"key":"e_1_2_7_224_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-015-9477-2"},{"key":"e_1_2_7_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92831-7"},{"key":"e_1_2_7_226_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2210-6"},{"key":"e_1_2_7_227_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar575"},{"key":"e_1_2_7_228_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-9006-9_1"},{"key":"e_1_2_7_229_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0408-y"},{"key":"e_1_2_7_230_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8492353"},{"key":"e_1_2_7_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.12.059"},{"issue":"6","key":"e_1_2_7_232_1","first-page":"945","article-title":"Hypoxia inducible factor\u20101\u2010alpha (HIF\u20101alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis","volume":"27","author":"Brouwer E","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_233_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930903143083"},{"key":"e_1_2_7_234_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22052"},{"key":"e_1_2_7_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.175"},{"key":"e_1_2_7_236_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.10.8411"},{"key":"e_1_2_7_237_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31824eca94"},{"key":"e_1_2_7_238_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215582"},{"key":"e_1_2_7_239_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-007-0024-y"},{"key":"e_1_2_7_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80209-3"},{"key":"e_1_2_7_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.12.018"},{"key":"e_1_2_7_242_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.478545"},{"key":"e_1_2_7_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2019.100228"},{"key":"e_1_2_7_244_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200311000-00006"},{"key":"e_1_2_7_245_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2020.00184.5"},{"key":"e_1_2_7_246_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2022.2085738"},{"key":"e_1_2_7_247_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2020.1719132"},{"key":"e_1_2_7_248_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010273"},{"key":"e_1_2_7_249_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1917508"},{"key":"e_1_2_7_250_1","doi-asserted-by":"publisher","DOI":"10.4236\/fns.2014.513132"},{"key":"e_1_2_7_251_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666181101110050"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.21990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T09:30:41Z","timestamp":1707298241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.21990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":250,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/med.21990"],"URL":"https:\/\/doi.org\/10.1002\/med.21990","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"assertion":[{"value":"2022-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}