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Historically, treatments normally include pain\u2010killing medication, anti\u2010inflammatory drugs, corticosteroids, and immunosuppressant drugs. However, given the above characteristics, treatment of autoimmune diseases has always been a challenge. Artemisinin is a natural sesquiterpene lactone initially extracted and separated from Chinese medicine <jats:italic>Artemisia annua<\/jats:italic> L., which has a long history of curing malaria. Artemisinin's derivatives such as artesunate, dihydroartemisinin, artemether, artemisitene, and so forth,\u00a0are a family of artemisinins with antimalarial activity. Over the past decades, accumulating evidence have indicated the promising therapeutic potential of artemisinins in autoimmune diseases. Herein, we systematically summarized the research regarding the immunoregulatory properties of artemisinins including artemisinin and its derivatives, discussing their potential therapeutic viability toward major autoimmune diseases and the underlying mechanisms. This review will provide new directions for basic research and clinical translational medicine of artemisinins.<\/jats:p>","DOI":"10.1002\/med.22001","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T19:21:24Z","timestamp":1701890484000},"page":"867-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Artemisinins: Promising drug candidates for the treatment of autoimmune diseases"],"prefix":"10.1002","volume":"44","author":[{"given":"Xu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Rheumatism and Immunology Peking University Shenzhen Hospital Shenzhen China"},{"name":"Institute of Immunology and Inflammatory Diseases Shenzhen Peking University\u2010The Hong Kong University of Science and Technology Medical Center Shenzhen China"},{"name":"Shenzhen Key Laboratory of Inflammatory and Immunology Diseases Shenzhen 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