{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T14:50:11Z","timestamp":1771858211182,"version":"3.50.1"},"reference-count":285,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medicinal Research Reviews"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As a nuclear transcription factor, the androgen receptor (AR) plays a crucial role not only in normal male sexual differentiation and growth of the prostate, but also in benign prostatic hyperplasia, prostatitis, and prostate cancer. Multiple population\u2010based epidemiological studies demonstrated that prostate cancer risk was inversely associated with increased dietary intakes of green tea, soy products, tomato, and so forth. Therefore, this review aimed to summarize the structure and function of AR, and further illustrate the structural basis for antagonistic mechanisms of the currently clinically available antiandrogens. Due to the limitations of these antiandrogens, a series of natural AR inhibitors have been identified from edible plants such as fruits and vegetables, as well as folk medicines, health foods, and nutritional supplements. Hence, this review mainly focused on recent experimental, epidemiological, and clinical studies about natural AR inhibitors, particularly the association between dietary intake of natural antiandrogens and reduced risk of prostatic diseases. Since natural products offer multiple advantages over synthetic antiandrogens, this review may provide a comprehensive and updated overview of dietary\u2010derived AR inhibitors, as well as their potential for the nutritional intervention against prostatic disorders.<\/jats:p>","DOI":"10.1002\/med.22019","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:38:32Z","timestamp":1706369912000},"page":"1446-1500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Recent advances in dietary androgen receptor inhibitors"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-4265","authenticated-orcid":false,"given":"Li","family":"Ren","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiehua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-2021","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029835"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.12.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0736237100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(67)90107-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00801"},{"key":"e_1_2_10_8_1","first-page":"875","article-title":"Enzalutamide as a second generation antiandrogen for treatment of advanced prostate cancer","volume":"7","author":"Semenas J","year":"2013","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax0428"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"365","article-title":"Mechanisms of resistance in castration\u2010resistant prostate cancer (CRPC)","volume":"4","author":"Chandrasekar T","year":"2015","journal-title":"Transl Androl Urol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.07.005"},{"issue":"6","key":"e_1_2_10_12_1","first-page":"425","article-title":"Tea and cancer: a review of the epidemiological evidence","volume":"5","author":"Blot WJ","year":"1996","journal-title":"Eur J Cancer Prev"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-0981-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-017-0005-x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2016.06.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201098n"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004571200"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm011072j"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.09.036"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407046200"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500381102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507464200"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051905906"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611711200"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703268200"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309106039340"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705524200"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708036104"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444907045702"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.09.002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.085779"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2000097"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200532b"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300249m"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3015712"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1886"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.06.009"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5009049"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01168"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14388"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.03.038"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.04.018"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00373"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020274"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081565498"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.10.085"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm061101w"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0843"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm801583j"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401123101"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.653792"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21558"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.04.021"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020456u"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000075099.20662.7f"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2017.1392320"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.184"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2019.10.003"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2012.1"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.07.034"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.345"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.08.012"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100276"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00632-5"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00137"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500802j"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.08.016"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052493"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.04.027"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol802021w"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.734475"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107991"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2014056"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66398"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0161"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-021-01202-6"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0985"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807282106"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061469"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1546082"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01116.x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13430"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3250"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2008.00397.x"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23000"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.10.017"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.10.020"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-1296"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.881363"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200305109"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-6-1521"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0373"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25210"},{"issue":"2","key":"e_1_2_10_94_1","first-page":"405","article-title":"Down\u2010regulation of androgen\u2010receptor and PSA by phytochemicals","volume":"32","author":"Chen S","year":"2008","journal-title":"Int J Oncol"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2380"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-990233"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.10.006"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0670-3"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23298"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17852"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina54030039"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00180"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0168"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071066"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43222"},{"issue":"2","key":"e_1_2_10_106_1","first-page":"153","article-title":"The inhibitory effect of Scutellaria baicalensis extract and its active compound, baicalin, on the translocation of the androgen receptor with implications for preventing androgenetic alopecia","volume":"80","author":"Kim A\u2010R","year":"2014","journal-title":"Planta Med"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.06.073"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25949"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-007-1772-3"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0240"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174251"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.3.409"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.9.1399"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20670"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt123"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20774"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300588200"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908908106"},{"issue":"3","key":"e_1_2_10_119_1","first-page":"631","article-title":"Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells","volume":"20","author":"Chiao J","year":"2002","journal-title":"Int J Oncol"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1335"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh136"},{"issue":"6","key":"e_1_2_10_122_1","first-page":"1215","article-title":"Modulation of growth of human prostate cancer cells by the N\u2010acetylcysteine conjugate of phenethyl isothiocyanate","volume":"16","author":"Chiao JW","year":"2000","journal-title":"Int J Oncol"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993758"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.166"},{"issue":"12","key":"e_1_2_10_125_1","article-title":"Screening of azaphilone derivatives from Monascus pilosus\u2010fermented rice (red yeast rice) and their evaluation as nonsteroidal androgen receptor antagonists","volume":"14","author":"Wu M\u2010D","year":"2019","journal-title":"Nat Prod Commun"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00426.x"},{"issue":"5","key":"e_1_2_10_127_1","first-page":"291","article-title":"Bakuchiol inhibits the androgen induced\u2010proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity","volume":"30","author":"Miao L","year":"2013","journal-title":"Tianjin J Tradit Chin Med"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4055"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-167924"},{"issue":"23","key":"e_1_2_10_130_1","first-page":"5892","article-title":"Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells","volume":"59","author":"Mitchell SH","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007398"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0231"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.219"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.007054"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-009-9304-y"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27754"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20742"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604227"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172546"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-011-0609-8"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.05.020"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.03.005"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0916"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14267"},{"issue":"8","key":"e_1_2_10_145_1","first-page":"797","article-title":"Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8\u2010pentamethyl\u20106\u2010chromanol in human prostate carcinoma cells","volume":"2","author":"Thompson TA","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102014399"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151525"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600037"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.61"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11844"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi155"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(92)90193-O"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO01612A"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.169997"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00773"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00087"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)01034-0"},{"key":"e_1_2_10_158_1","first-page":"3279","article-title":"Dietary phytochemicals as modulators of human pregnane X receptor","volume":"663","author":"Zhang J","year":"2021","journal-title":"Crit Rev Food Sci Nutr"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1514580"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4972"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112700"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.08.007"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065889"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20001101)45:3<259::AID-PROS9>3.0.CO;2-G"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-946638"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/0753-3322(96)82662-X"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.09.013"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-941472"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1170"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520611313050014"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93447-W"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11662-7"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8274.CD-10-0020"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110106"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2014.03.001"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1034290"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.2991\/efood.k.210329.001"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02002A"},{"issue":"6","key":"e_1_2_10_179_1","first-page":"431","article-title":"Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c\u2010Jun and androgen receptor","volume":"68","author":"Guo H","year":"2013","journal-title":"Pharmazie"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2010.26"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2015.56.9.656"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.04.024"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.098"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25678"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.02.005"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3841-9"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/efd2.3"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/efd2.13"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.50"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.129"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112265"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153736"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi021"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.04.003"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.07.037"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0388-7"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.41686"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111548"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.12.053"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v6.i3.144"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209146"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-818965"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.08.021"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.04.014"},{"issue":"5","key":"e_1_2_10_205_1","first-page":"753","article-title":"Transcriptional regulation of prostate kallikrein\u2010like genes by androgen","volume":"6","author":"Wolf DA","year":"1992","journal-title":"Mol Endocrinol"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9091680"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2018.05.010"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.04.004"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0087"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.7243\/2049-7962-1-30"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215384"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23013"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.117"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20528"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm144"},{"issue":"10","key":"e_1_2_10_216_1","first-page":"3323","article-title":"Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells","volume":"31","author":"Kai L","year":"2011","journal-title":"Anticancer Res"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1114-7"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1865"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC421_1"},{"issue":"1","key":"e_1_2_10_220_1","first-page":"187","article-title":"Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention","volume":"24","author":"Wang L","year":"2004","journal-title":"Int J Oncol"},{"issue":"2","key":"e_1_2_10_221_1","first-page":"227","article-title":"Sulforaphane retards the growth of human PC\u20103 xenografts and inhibits HDAC activity in human subjects","volume":"232","author":"Myzak MC","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3502"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2016.08.005"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.2991\/efood.k.200512.001"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.05.001"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24695"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines8060028"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.97"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2021.105828"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00720-7"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112411"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153002"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112379"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2978"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735421996824"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1965"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2022.2040528"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.11.008"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.2991\/efood.k.200427.001"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404143301501"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.6.440"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj050"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601360"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC3601_13"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(00)00006-0"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.108"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.2991\/efood.k.191118.001"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.11.026"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02023-5"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-016-0334-y"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65724-2"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7075230"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.39"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.65"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2269"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.10.001"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi323"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203511"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01774.x"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1145"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0167"},{"key":"e_1_2_10_262_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.96"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0221"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2011.582221"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-9985-y"},{"issue":"16","key":"e_1_2_10_266_1","first-page":"2231","article-title":"Effect of lycopene on androgen receptor and prostate\u2010specific antigen velocity","volume":"123","author":"Xin Z","year":"2010","journal-title":"Chin Med J"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.64"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90467-0"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.23.1767"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222701003"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn011"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1905fje"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1116fje"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113129"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-52"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0857"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn190"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr020"},{"key":"e_1_2_10_279_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.7043"},{"key":"e_1_2_10_280_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.2.595"},{"key":"e_1_2_10_281_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2014.52"},{"key":"e_1_2_10_282_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9407-y"},{"key":"e_1_2_10_283_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00475-5"},{"key":"e_1_2_10_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.04.027"},{"key":"e_1_2_10_285_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0056"},{"key":"e_1_2_10_286_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-017-0693-8"}],"container-title":["Medicinal Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/med.22019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T04:14:14Z","timestamp":1717906454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/med.22019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":285,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/med.22019"],"URL":"https:\/\/doi.org\/10.1002\/med.22019","archive":["Portico"],"relation":{},"ISSN":["0198-6325","1098-1128"],"issn-type":[{"value":"0198-6325","type":"print"},{"value":"1098-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,27]]},"assertion":[{"value":"2022-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}