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As a result, EGFR inhibition has become an attractive anticancer drug design strategy, and a large number of small molecular inhibitors have been developed. Despite the widespread clinical use of EGFR tyrosine kinase inhibitors (TKIs), their drug resistance, inadequate accumulation in tumors, and severe side effects have spurred the search for better antitumor drugs. Metal complexes have attracted much attention because of their different mechanisms compared with EGFR\u2010TKIs. Therefore, the combination of metals and inhibitors is a promising anticancer strategy. For example, Ru and Pt centers are introduced to design complexes with double or multiple targets, while Au complexes are combined with inhibitors to overcome drug resistance. Co complexes are designed as prodrugs with weak side effects and enhanced targeting by the hypoxia activation strategy, and other metals such as Rh and Fe enhance the anticancer effect of the complexes. In addition, the introduction of Ga center is beneficial to the development of nuclear imaging tracers. In this paper, metal EGFR\u2010TKI complexes in the last 15 years are reviewed, their mechanisms are briefly introduced, and their advantages are summarized.<\/jats:p>","DOI":"10.1002\/med.22021","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:48:43Z","timestamp":1706370523000},"page":"1545-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metal complexes bearing EGFR\u2010inhibiting ligands as promising anticancer agents"],"prefix":"10.1002","volume":"44","author":[{"given":"Xiaoyan","family":"Ma","sequence":"first","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine Nanjing University of Chinese Medicine Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu 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