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Its prevalence is forecasted to exponentially increase during the next 30 years due to the global aging population. Currently, approved drugs are merely symptomatic, being ineffective in delaying or blocking the relentless disease advance. Intensive AD research describes this disease as a highly complex multifactorial disease. Disclosure of novel pathological pathways and their interconnections has had a major impact on medicinal chemistry drug development for AD over the last two decades. The complex network of pathological events involved in the onset of the disease has prompted the development of multitarget drugs. These chemical entities combine pharmacological activities toward\u00a0two or more drug targets of interest. These multitarget\u2010directed ligands are proposed to modify different nodes in the pathological network aiming to delay or even stop disease progression. Here, we review the multitarget drug development strategy for AD during the last decade.<\/jats:p>","DOI":"10.1002\/med.22045","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T17:10:20Z","timestamp":1714324220000},"page":"2367-2419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Innovative pathological network\u2010based multitarget approaches for Alzheimer's disease treatment"],"prefix":"10.1002","volume":"44","author":[{"given":"Paloma","family":"Mayo","sequence":"first","affiliation":[{"name":"Departamento de desarrollo precl\u00ednico Fundaci\u00f3n Te\u00f3filo Hernando Las Rozas Madrid Spain"},{"name":"Departamento de Farmacolog\u00eda y Terap\u00e9utica, Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Instituto de Qu\u00edmica M\u00e9dica, Consejo Superior de Investigaciones Cient\u00edficas (IQM\u2010CSIC) Madrid 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